MRI-based treatment planning and dose delivery verification for intraocular melanoma brachytherapy

Zoberi, Jacqueline E.; Garcia-Ramirez, José; Hedrick, Samantha G.; Rodriguez, Vivian; Bertelsman, C.; Mackey, Stacie L.; Hu, Yanle; Gach, H. Michael; Rao, P. Kumar; Grigsby, Perry W.

doi:10.1016/j.brachy.2017.07.011

Cited by 22 publications

(24 citation statements)

References 22 publications

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“…Our survey results and the literature demonstrate that the tradeoff of better coverage and adequate dosing versus excessive toxicity is far from settled [7-10, 12, 13]. Prescribing to the apex for tumors < 5 mm, particularly large or thin tumors, may result in low basal doses, and there is concern that there is insufficient margin to avoid error for tilted or displaced plaques [7,8,13]. Supporting the argument of prescribing to the apex for tumors < 5 mm, one retrospective study compared 10-year outcomes for patients prescribed 85 Gy to the apex or 5 mm.…”

Section: Discussionmentioning

confidence: 98%

“…Current guidelines acknowledge pending questions regarding ideal prescription dose and dose rate, plaque size selection, and efficacy of notched and slotted plaques in preventing underdosing of juxtapapillary and circumpapillary tumors. Several publications have questioned the radiation therapy prescription dose and dose point [5][6][7][8][9][10][11][12][13]. Moreover, strict adherence to a planning treatment volume (PTV) with a 2-3 mm circumferential margin has been called into question.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, strict adherence to a planning treatment volume (PTV) with a 2-3 mm circumferential margin has been called into question. Experimental modeling and in vivo imaging for location verification indicate that 2-3 mm may be inadequate for tumors with large uncer-tainties in size or difficult plaque placement [7,[13][14][15][16][17][18]. Generally, studies advocate for a larger PTV.…”

Section: Introductionmentioning

confidence: 99%

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Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5

et al. 2019

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Background: Treatment planning for I-125 plaque therapy for uveal melanoma has advanced significantly since the Collaborative Ocular Melanoma Study trial, with more widely available image-guided planning and improved dosimetry. Objective: We evaluated real-world practice patterns for I-125 plaque brachytherapy in the United States by studying practice patterns at centers that comprise the Ocular Oncology Study Consortium (OOSC). Methods: The OOSC database and responses to a treatment practice survey were eval-I-125 Plaque Brachytherapy Clinical Practices 211practices was high among OOSC institutions. Clinical margins and planning systems were similar among institutions, while prescription dose, dose rates, and dosimetry varied.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5

et al. 2019

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“…Gold, which is diamagnetic and present in many plaque designs, can cause a significant susceptibility artefact, impairing the image near the plaque. Thus, there are limited opportunities for imaging therapeutic ocular plaques in vivo , however recent work reports on MRI‐based treatment planning and dose verification …”

Section: Quality Management and Assurance Processes For Ocular Plaque Bmentioning

confidence: 99%

AAPM recommendations on medical physics practices for ocular plaque brachytherapy: Report of task group 221

et al. 2020

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The American Association of Physicists in Medicine (AAPM) formed Task Group 221 (TG-221) to discuss a generalized commissioning process, quality management considerations, and clinical physics practice standards for ocular plaque brachytherapy. The purpose of this report is also, in part, to aid the clinician to implement recommendations of the AAPM TG-129 report, which placed emphasis on dosimetric considerations for ocular brachytherapy applicators used in the Collaborative Ocular Melanoma Study (COMS). This report is intended to assist medical physicists in establishing a new ocular brachytherapy program and, for existing programs, in reviewing and updating clinical practices. The report scope includes photon-and beta-emitting sources and source:applicator combinations. Dosimetric studies for photon and beta sources are reviewed to summarize the salient issues and provide references for additional study. The components of an ocular plaque brachytherapy quality management program are discussed, including radiation safety considerations, source calibration methodology, applicator commissioning, imaging quality assurance tests for treatment planning, treatment planning strategies, and treatment planning system commissioning. Finally, specific guidelines for commissioning an ocular plaque brachytherapy program, clinical physics practice standards in ocular plaque brachytherapy, and other areas reflecting the need for specialized treatment planning systems, measurement phantoms, and detectors (among other topics) to support the clinical practice of ocular brachytherapy are presented. Expected future advances and developments for ocular brachytherapy are discussed.

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“…At our institution, eye plaque patients typically receive fundoscopy, ultrasound, and magnetic resonance imaging (MRI) for brachytherapy treatment planning [ 9 ]. MRI has superior soft tissue contrast to CT and is non-ionizing.…”

Section: Purposementioning

confidence: 99%

Magnetic resonance imaging metal artifact reduction for eye plaque patient with dental braces

Gach¹,

Mackey²,

Rehman³

et al. 2017

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PurposeTo determine if metal artifact reduction can minimize magnetic susceptibility artifacts in the orbits for an eye plaque brachytherapy patient with metallic dental braces.Material and methodsA 62-year-old female patient with a choroidal melanoma in the right eye received a 1.5 T magnetic resonance imaging (MRI) simulation for 3D eye plaque brachytherapy planning. The protocol included conventional 3D T1-weighted and 2D T2-weighted MRIs. A vendor-supplied T2-weighted metal artifact reduction sequence was added to the protocol to reduce magnetic susceptibility artifacts from the metallic dental braces. The metal artifact reduction sequence combined turbo spin echo acquisitions, high RF excitation and readout bandwidths, and view angle tilting and slice encoding for metal artifact correction with z-shimming to correct in-plane and through-plane image distortions, respectively.ResultsDental braces caused significant signal loss and image distortion in the orbits on the conventional T1-weighted and T2-weighted MRIs, and the MRIs were unusable for treatment planning. The metal artifact reduction sequence with 13 z-phase encodes minimized distortion and signal loss in the orbits, allowing the tumor to be clearly delineated.ConclusionsT2-weighted MRI with metal artifact reduction was successfully applied to minimize artifacts in the orbits resulting from the dental braces, thus allowing the MRIs to be used in 3D brachytherapy treatment planning.

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MRI-based treatment planning and dose delivery verification for intraocular melanoma brachytherapy

Cited by 22 publications

References 22 publications

Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5

Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5

AAPM recommendations on medical physics practices for ocular plaque brachytherapy: Report of task group 221

Magnetic resonance imaging metal artifact reduction for eye plaque patient with dental braces

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