MRI characteristics of familial and sporadic multiple sclerosis patients

Tipirneni, Anita; Weinstock‐Guttman, Bianca; Ramanathan, Murali; Abdelrahman, Nadir; Hussein, Sara; Hagemeier, Jesper; Durfee, Jacqueline; Teter, Barbara; Hojnacki, David; Dwyer, Michael G.; Zivadinov, Robert

doi:10.1177/1352458512469697

Cited by 13 publications

(8 citation statements)

References 44 publications

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“…Family members were classified into first-, second-, and third-degree relatives as described previously. 10 There were 47 subjects in sporadic and 21 subjects in familial HC subgroups. Both subgroups were merged into 1 group composed of healthy relatives of patients with MS.…”

Section: Subjectsmentioning

confidence: 99%

“…8 However, other studies did not show clinical differences among familial and non-familial healthy control subject (non-fMS) forms. 2,9 Nevertheless, MR imaging studies by use of nonconventional techniques showed MR imaging differences between familial and non-familial MS. [10][11][12] In 2009, Okuda et al 13 introduced the term "radiologically isolated syndrome" (RIS) to describe subjects who show incidental brain MR imaging WM lesions suggestive of MS and who fulfill Barkhof criteria for dissemination in space (DIS) 14 but have no signs or symptoms of the disease. Overall, the prevalence of RIS is, according to postmortem studies, in a range of 0.06 -0.7%, with an age range of 16 -70.…”

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confidence: 99%

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Prevalence of Radiologically Isolated Syndrome and White Matter Signal Abnormalities in Healthy Relatives of Patients with Multiple Sclerosis

Gabelić

Ramasamy

Weinstock‐Guttman

et al. 2013

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The exact prevalence of WM signal abnormalities in healthy relatives of MS patients and their impact on disease development has not been fully elucidated. The purpose of this study was to compare WM signal abnormality characteristics and the prevalence of radiologically isolated syndrome in healthy control subjects selected randomly from the population with the healthy relatives of patients with MS.

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Section: Subjectsmentioning

confidence: 99%

mentioning

confidence: 99%

Prevalence of Radiologically Isolated Syndrome and White Matter Signal Abnormalities in Healthy Relatives of Patients with Multiple Sclerosis

Gabelić

Ramasamy

Weinstock‐Guttman

et al. 2013

AJNR Am J Neuroradiol

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“…Patients with non-vascular etiology of WM lesions like MS can have heterogeneous presentations, which might partially reflect the variety of the clinical disease course and the evolution. While familial MS was associated with more severe T1-lesion volume, there were no clinical status differences between family and sporadic MS patients (66). Whereas, genetic factors can make familial MS patients more inclined to develop the disease than sporadic patients, other factors such as the environmental influence and the subjective (genetic) differences in response to injury seem to be critical for developing a diffuse and perhaps clinically significant development-relevant pathology in MS. Biologic confounders could influence the analysis of GM volumes, including the introduction of disease-modifying therapies, physiologic factors, normal aging, comorbidities, and daily fluctuations in brain volumes (67).…”

Section: Figure 4 | (A)mentioning

confidence: 82%

Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study

et al. 2021

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Diffusion tensor imaging (DTI) is a noninvasive, quantitative MRI technique that measures white matter (WM) integrity. Many brain dimensions are heritable, including white matter integrity measured with DTI. Family studies are valuable to provide insights into the interactive effects of non-environmental factors on multiple sclerosis (MS). To examine the contribution of familial factors to the diffusion signals across WM microstructure, we performed DTI and calculated neurite orientation dispersion plus density imaging (NODDI) diffusion parameters in two patient groups comprising familial and sporadic forms of multiple sclerosis and their unaffected relatives. We divided 111 subjects (49 men and 62 women: age range 19–60) into three groups conforming to their MS history. The familial MS group included 30 participants (patients; n = 16, healthy relatives; n = 14). The sporadic group included 41 participants (patients; n = 10, healthy relatives; n = 31). Forty age-matched subjects with no history of MS in their families were defined as the control group. To study white matter integrity, two methods were employed: one for calculating the mean of DTI, FA, and MD parameters on 18 tracts using Tracts Constrained by Underlying Anatomy (TRACULA) and the other for whole brain voxel-based analysis using tract-based spatial statistics (TBSS) on NDI and ODI parameters derived from NODDI and DTI parameters. Voxel-based analysis showed considerable changes in FA, MD, NDI, and ODI in the familial group when compared with the control group, reflecting widespread impairment of white matter in this group. The analysis of 18 tracts with TRACULA revealed increased MD and FA reduction in more tracts (left and right ILF, UNC, and SLFT, forceps major and minor) in familial MS patients vs. the control group. There were no significant differences between the patient groups. We found no consequential changes in healthy relatives of both patient groups in voxel-based and tract analyses. Considering the multifactorial etiology of MS, familial studies are of great importance to clarify the effects of certain predisposing factors on demyelinating brain pathology.

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“…They demonstrated that familial MS is correlated with more severe T1-lesion volume and its MTR characteristics. Moreover, no clinical differences were found between the two groups of MS patients [ 37 ]. Growing number of new MS cases among family members in future has been reported and there are variations in the clinical path and survival between the genders of intermittent and familial cases [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis projection in Tehran, Iran using Bayesian structural time series

et al. 2021

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Background The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the highest prevalence ratio among Asian countries was reported in Iran. This study aims to estimate the increase in MS occurrence during more than three decades in Tehran and forecast the future condition of the disease using time series approaches for the next ten years. Methods The cross-sectional study was conducted from 1999 to 2019 based on records of MS cases from Iranian MS Society (IMSS) registry system. The prevalence was estimated using population data presented by the Statistical Centre of Iran. Through Bayesian Structural Time Series (BSTS) model, we want to predict the prevalence of familial and sporadic MS in the next ten years. . Results Among 22,421 cases with MS, 16,831 (75.1 %) were female and 5589 (24.9 %) were male. Female to male ratio was 3.0:1 and the number of familial MS cases were 2982 (13.3 %) of subjects. Female gender was less responsible for higher rate of MS in familial definition (beta = 0.020) in comparison to sporadic cases (beta = 0.034). Forecasting by BSTS revealed an increase in MS prevalence for the next ten years so that the prevalence rate for total, familial and sporadic MS respectively begins with 189.50 (183.94-195.14), 25.69 (24.97–26.45) and 163.74(159.06-168.57) in 2020 and ends with 220.84 (171.48-266.92), 30.79 (24.16–37.15), and 189.33(146.97-230.19) in 2029. Conclusions According to the findings, MS prevalence increased during three decades and it will increase over the next ten years. Tehran province is one of the regions with highest MS prevalence in Asia. The results of present study indicated that females are at higher risk for MS than males in both sporadic and familial MS.

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MRI characteristics of familial and sporadic multiple sclerosis patients

Cited by 13 publications

References 44 publications

Prevalence of Radiologically Isolated Syndrome and White Matter Signal Abnormalities in Healthy Relatives of Patients with Multiple Sclerosis

Prevalence of Radiologically Isolated Syndrome and White Matter Signal Abnormalities in Healthy Relatives of Patients with Multiple Sclerosis

Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study

Multiple sclerosis projection in Tehran, Iran using Bayesian structural time series

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