MRI characteristics of trigeminal nerve involvement in patients with multiple sclerosis

C, Swinnen; Lunskens, Sophie; Deryck, Olivier; Casselman, Jan; Vanopdenbosch, Ludo

doi:10.1016/j.msard.2012.12.002

Cited by 22 publications

(13 citation statements)

References 12 publications

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“…The trigeminal nerve has three principal sensory nuclei: the primary sensory nucleus (touch and position sensation), mesencephalic nucleus (proprioception), and the spinal nucleus and tract (pain and temperature sensation). With the intrapontine fascicular part of the trigeminal nerve they form the brainstem part of the trigeminal afferent pathway (5). MRI studies have shown that the intrapontine fascicular part of the trigeminal nerve is most frequently affected, while the lesions in the spinal nucleus and tract and the intrapontine fascicular part of the trigeminal nerve correspond with trigeminal neuralgia (5).…”

Section: Discussionmentioning

confidence: 99%

“…With the intrapontine fascicular part of the trigeminal nerve they form the brainstem part of the trigeminal afferent pathway (5). MRI studies have shown that the intrapontine fascicular part of the trigeminal nerve is most frequently affected, while the lesions in the spinal nucleus and tract and the intrapontine fascicular part of the trigeminal nerve correspond with trigeminal neuralgia (5). On the other hand, in none of the published studies pain, temperature, and/or touch sensation correlated with the presence of brainstem lesions (17).…”

Section: Discussionmentioning

confidence: 99%

“…A common finding in MS patients are sensory symptoms (numbness, dysesthesia, or paresthesia) in trigeminal nerve regions (5). The trigeminal nerve is the most commonly involved isolated cranial nerve in MS (6).…”

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confidence: 99%

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Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Skorić¹,

Adamec²,

Crnošija³

et al. 2016

Croat Med J

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AimTo test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP results in the form of the tSSEP score enables better evaluation of the afferent trigeminal pathway involvement than analyzing each tSSEP parameter separately.Methods115 consecutive CIS patients were enrolled from August 1, 2014 until March 1, 2016. Facial sensory symptoms and brainstem MRI (1.5 T) lesions were analyzed. tSSEP testing was performed for each patient from the raw tSSEP data. The tSSEP score was calculated separately for the left and right side (according to the cut-off values for absent response and prolonged latency of the main component, P1 (0 = normal response, 1 = prolonged latency, 3 = absent response) and the two values were summed.ResultsThere was no difference in the absolute values of the tSSEP variables regarding the presence of clinical symptoms. No association was found between tSSEP abnormalities and clinical symptoms (P = 0.544). Brainstem lesions (midbrain and pons) were associated with the absent tSSEP responses (P = 0.002 and P = 0.005, respectively). tSSEP score was significantly higher in patients with brainstem lesions (P = 0.01), especially midbrain (P = 0.004) and pontine (P = 0.008) lesions. Binary logistic regression showed that tSSEP score had a significant effect on the likelihood that patients have midbrain MR lesions, χ2(1) = 6.804, P = 0.009; and the model correctly classified 87% of cases.ConclusionsThe consistent finding of this study was the association between tSSEP and midbrain lesions on MRI, indicating that tSSEP evaluates proprioception of the face. This study establishes the value of tSSEP in assessing brainstem function in early multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Skorić¹,

Adamec²,

Crnošija³

et al. 2016

Croat Med J

View full text Add to dashboard Cite

show abstract

“…NMO preferentially involves the optic nerve and spinal cord, and has a characteristic distribution of brain lesions different from MS on magnetic resonance imaging (MRI) [1], including the brainstem lesions [2]. Trigeminal neuralgia and sensory disturbance are common in MS, and frequent trigeminal root entry zone (REZ) involvement has been reported [3][4][5][6]. Although REZ involvement on MRI is regarded to be a distinctive MRI finding in MS [6], it has never been investigated in NMO.…”

Section: Introductionmentioning

confidence: 99%

“…Trigeminal neuralgia and sensory disturbance are common in MS, and frequent trigeminal root entry zone (REZ) involvement has been reported [3][4][5][6]. Although REZ involvement on MRI is regarded to be a distinctive MRI finding in MS [6], it has never been investigated in NMO. Therefore, it is unclear whether there are differences in the frequency of trigeminal REZ involvement between MS and NMO.…”

Section: Introductionmentioning

confidence: 99%

Trigeminal root entry zone involvement in neuromyelitis optica and multiple sclerosis

Sugiyama

Mori

Masuda

et al. 2015

Journal of the Neurological Sciences

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Neuroimmunology

Swenson¹

2019

Atlas of Clinical Neurology

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MRI characteristics of trigeminal nerve involvement in patients with multiple sclerosis

Cited by 22 publications

References 12 publications

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Trigeminal root entry zone involvement in neuromyelitis optica and multiple sclerosis

Neuroimmunology

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