MRI‐Derived Biomarkers Related to Sarcopenia: A Systematic Review

Codari, Marina; Zanardo, Moreno; Sabato, Maria Eugenia di; Nocerino, Elisabetta; Messina, Carmelo; Sconfienza, Luca Maria; Sardanelli, Francesco

doi:10.1002/jmri.26931

Cited by 29 publications

(31 citation statements)

References 63 publications

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“…Muscle mass can be measure by several techniques though none are ideal with major limitations. The most effective to date seems to be the dual-energy X-ray absorptiometry (DXA) but CT (especially Lumbar 3 rd vertebra by CT imaging in cancer patients including MM [63]) and more recently MRI scanning have been advocated, the latter being able to pose a calibration of muscle quality as well as mass [62,64,65]. One promising approach is the d3 creatinine A isotope dilution test, which has generated more correlative results with sarcopenia than DXA [66].…”

Section: Biomarkers Of Frailtymentioning

confidence: 99%

Defining the vulnerable patient with myeloma—a frailty position paper of the European Myeloma Network

et al. 2020

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As the treatment landscape continues to evolve towards the application of precision medicine in multiple myeloma (MM), there is a clear need to identify those patients who are at risk of not achieving the maximum benefit whilst exposed to the highest level of toxicity. This group of patients, defined as frail, is an unmet clinical need. However, how we define such a vulnerable group of patients with MM remains to be clarified. An integral aspect of this is to define the physiological age and capacity of patients with MM to deal with the burden of their disease and it's treatment. Such assessments may include not only functional and clinical assessments but also laboratory-based biomarkers of frailty, aging and senescent cellular burden. A need to develop, test and validate clinical screening scores before their adoption into clinical practice is mandated. This position paper from the European Myeloma Network aims to review what is known about defining frailty in MM, and how we can advance this knowledge for the design of clinical trials and ultimately how we deliver treatment in the clinic.

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Section: Biomarkers Of Frailtymentioning

confidence: 99%

Defining the vulnerable patient with myeloma—a frailty position paper of the European Myeloma Network

et al. 2020

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“…When compared to the high magnetic fields applied in medical applications (1.5-3 T in magnetic resonance imaging (MRI) scans [17] ), the cells in our setup are exposed to 10-30 times lower static magnetic strength for a short term. When compared to the high magnetic fields applied in medical applications (1.5-3 T in magnetic resonance imaging (MRI) scans [17] ), the cells in our setup are exposed to 10-30 times lower static magnetic strength for a short term.…”

Section: Doi: 101002/adma201904598mentioning

confidence: 99%

“…Taken together, these findings show that the cellular loading with MNPs and the relative low external magnetic field applied (0.1-0.2 T) are sufficient to drive the cardiac cells along the field lines and pattern them to the desired controlled geometries within the collagen hydrogels. When compared to the high magnetic fields applied in medical applications (1.5-3 T in magnetic resonance imaging (MRI) scans [17] ), the cells in our setup are exposed to 10-30 times lower static magnetic strength for a short term. Under these conditions no harmful effects to the cells were observed, and viable and functional cardiac tissues were formed.…”

Section: Doi: 101002/adma201904598mentioning

confidence: 99%

Remote Magnetic Nanoparticle Manipulation Enables the Dynamic Patterning of Cardiac Tissues

et al. 2019

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regenerative medicine and remains a major challenge. A multitude of technologies have been described to control the spatial organization of cells in 3D engineered heart constructs including mechanical strain/load [1] and chronic electrical stimulation. [2] Other approaches to guide cellular organization have been reported using microfluidic platforms, [3] light-triggered activation of biomolecules, [4] and 3D bioprinting. [5] However, these techniques often involve elaborate, macroscale stimulation systems and are not always suitable for the fabrication of detailed microarchitectures in vitro as each pattern requires new molds, posts, or frames. [6] The next generation of dynamic systems may be designed to respond to user-defined size and shape triggers for controlling cellular organization on the macroscale without the need for external mechanical supports or material cues. Magnetic procedures to manipulate and remotely control cellular behavior represent a promising approach for fabrication of tissuelike constructs. In particular, magnetic nanoparticles (MNPs) have gained increased attention for use in biomedical applications such as magnetic targeting of stem cells [7] and genes, [8] development of scaffold-free multilayer structures, [9] and spatial patterning of aggregates. [10] Magnetic techniques are advantageous due to their high precision and accuracy. To date, magnetic fabrication of biological structures has been illustrated by the assembly of biomembranes made of organized yeast, [11] the formation of "artificial retinas" by magnetic field modulation of chiromagnetic nanoparticles, [12] or the engineering of vocal folds, [13] among others.Here, we report a new platform for engineering tissue morphologies with controlled geometries. Specifically, we used magnetic fields to direct the assembly and patterning of magnetized human cardiomyocytes (CMs) labeled with MNPs in collagenbased hydrogels. Our system enables dynamic manipulation of cells within 3D biomaterials that can be applied to engineer patterned tissues to investigate cellular and tissue behavior. Furthermore, the simplicity and the faithful reproduction of our approach will enable the creation of customized 3D constructs with a new range of complementary implementations such as in biomedical devices, soft robotics, and flexible electronics.First, we designed functionalized MNPs to target and label human induced pluripotent-stem-cell-derived cardiomyocytes (hiPSC-CMs, Figure 1a). For that purpose, we conjugated an antisignal-regulatory protein alpha (SIRPA) cell surface mono clonal antibody [14] labeled with a fluorophore to three types of MNPsThe ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3D collagen hydrogels is developed to dynamically create various tailored microstructures of cardiac...

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“…[83][84][85] Poor awareness of these conditions among the general population accounts for underdiagnosis and consequently an increased risk of frailty, falls, fractures, and ultimately mortality. [86][87][88] Prevention, early diagnosis, and treatment should be a mandate of primary care providers. The standard imaging modality to assess BMD and body composition is dual X-ray absorptiometry (DXA).…”

Section: Quantitative Ultrasound In Osteosarcopeniamentioning

confidence: 99%

Quantitative Musculoskeletal Ultrasound

Gitto

Messina

Vitale

et al. 2020

Semin Musculoskelet Radiol

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Ultrasound (US) imaging plays a crucial role in the assessment of musculoskeletal (MSK) disorders. Several quantitative tools are offered by US systems and add information to conventional US imaging. This article reviews the quantitative US imaging tools currently available in MSK radiology, specifically focusing on the evaluation of elasticity with shear-wave elastography, perfusion with contrast-enhanced US and noncontrast superb microvascular imaging, and bone and muscle mass with quantitative US methods. Some of them are well established and already of clinical value, such as elasticity and contrast-enhanced perfusion assessment in muscles and tendons. MSK radiologists should be aware of the potential of quantitative US tools and take advantage of their use in everyday practice, both for clinical and research purposes.

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MRI‐Derived Biomarkers Related to Sarcopenia: A Systematic Review

Cited by 29 publications

References 63 publications

Defining the vulnerable patient with myeloma—a frailty position paper of the European Myeloma Network

Defining the vulnerable patient with myeloma—a frailty position paper of the European Myeloma Network

Remote Magnetic Nanoparticle Manipulation Enables the Dynamic Patterning of Cardiac Tissues

Quantitative Musculoskeletal Ultrasound

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