MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease

Kosta, Paraskevi; Argyropoulou, Maria I.; Markoula, Sofia; Konitsiotis, Spyridon

doi:10.1007/s00415-005-0914-9

Cited by 123 publications

(113 citation statements)

References 39 publications

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“…Our results are in concordance with several previous studies reporting increased iron depositions in the SN of patients with multiple system atrophy and IPD. 15,[42][43][44][45][46][47] A few studies [48][49][50] used SWI images to detect putative iron content in the brain as a tool to differentiate MSA-P from IPD. Gupta et al 49 investigated SWI for patterns of mineralization to differentiate progressive supranuclear palsy, IPD, and multiple system atrophy; minimum-intensity-projection images of SWI were used to obtain signal intensities of each nucleus, which did not demonstrate a significant difference between IPD and multiple system atrophy, though higher putaminal hypointensity scores were found in patients with multiple system atrophy compared with those with IPD.…”

Section: Discussionmentioning

confidence: 99%

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Wang¹,

Butros²,

Shuai³

et al. 2011

AJNR Am J Neuroradiol

136

122

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Section: Discussionmentioning

confidence: 99%

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Wang¹,

Butros²,

Shuai³

et al. 2011

AJNR Am J Neuroradiol

136

122

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“…Although the chemical composition of the ZI is yet not exactly known, we assume that the signal characteristics of the rZI are caused by iron deposits [20] . The association between iron deposition and neurodegenerative diseases has been described before [56,57] . Particularly in deep brain structures of PD patients (subthalamic region and basal ganglia) a progressive increase of iron concentration has been reported [58] .…”

Section: Discussionmentioning

confidence: 99%

Imaging for deep brain stimulation: The zona incerta at 7 Tesla

Kerl

Gerigk²,

Brockmann³

et al. 2013

WJR

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AIM:To evaluate different promising magnetic resonance imaging (MRI) methods at 7.0 Tesla (T) for the pre-stereotactic visualization of the zona incerta (ZI). METHODS:Two neuroradiologists qualitatively and quantitatively examined T2-turbo spin-echo (T2-TSE), T1-weighted gradient-echo, as well as FLASH2D-T2Star and susceptibility-weighted imaging (SWI) for the visualization of the ZI at 7.0 T MRI. Delineation and image quality for the ZI were independently examined using a 6-scale grading system. Inter-rater reliability using Cohen's kappa coefficient (κ ) were assessed. Contrast-tonoise ratios (CNR), and signal-to-noise ratios (SNR) for the ZI were calculated for all sequences. Differences in delineation, SNR, and CNR between the sequences were statistically assessed using a paired t -test. For the anatomic validation the coronal FLASH2D-T2Star images were co-registered with a stereotactic atlas (Schaltenbrand-Wahren). RESULTS:The rostral part of the ZI (rZI) could easily be identified and was best and reliably visualized in the coronal FLASH2D-T2Star images. The caudal part was not definable in any of the sequences. No major artifacts in the rZI were observed in any of the scans. FLASH2D-T2Star and SWI imaging offered significant higher CNR values for the rZI compared to T2-TSE images (P > 0.05). The co-registration of the coronal FLASH2D-T2Star images with the stereotactic atlas schema (Schaltenbrand-Wahren) confirmed the correct localization of the ZI in all cases.CONCLUSION: FLASH2D-T2Star imaging (particularly coronal view) provides the reliable and currently optimal visualization of the rZI at 7.0 T. These results can facilitate a better and more precise targeting of the caudal part of the ZI than ever before.

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“…The clinical diagnosis of PD is based on the symptoms of the akinetic rigid syndrome (usually with an asymmetric onset), a resting tremor and a sustained response to levodopa [1] . Definitive diagnosis of PD is confirmed by postmortem examination of the brain tissue of PD patients [2] , which has shown increased iron deposition in several cerebral regions in PD patients [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Determination of brain iron content in patients with Parkinson’s disease using magnetic susceptibility imaging

et al. 2009

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Objective To compare the phase radians in several cerebral regions between patients with Parkinson's disease (PD) and control subjects, and to evaluate whether iron deposition quantified by susceptibility-weighted imaging (SWI) is related to the severity of motor symptoms of PD. Methods SWI consisted of both magnitude and phase images from a fully flow-compensated, 3-dimensional and gradient-echo (GRE) sequence. Magnitude and phase data were collected at GE HD 1.5T.The regions evaluated included frontal white matter, grey matter, cerebrospinal fluid, putamen, caudate nucleus (CN), substantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr), and red nucleus (RN). A total number of 42 patients (12 patients without cognitive dysfunction, and 30 with cognitive dysfunction from mild to moderate degrees) and 30 control subjects were employed in the present study. Results The phase radians of SNc, CN and RN in PD patients were lower than those in control subjects (P<0.05). Conclusion The phase radians can be used to estimate the brain iron deposition in PD patients, which may be helpful in the diagnosis and longitudinal monitoring of PD.

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MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease

Abstract: These findings suggest that dysfunction of the basal ganglia circuitry in PD may affect iron content not only in SNc but in STN, Pu and GPe as well. Compensatory sprouting of the remaining dopaminergic fibers could account for the increased area of the CN and Pu.

Cited by 123 publications

References 39 publications

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Imaging for deep brain stimulation: The zona incerta at 7 Tesla

Determination of brain iron content in patients with Parkinson’s disease using magnetic susceptibility imaging

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