MRI features of the nested variant of urothelial carcinoma of the urinary bladder: report of four cases

Yamada, Kaori; Sasakura, Yasuteru; Yamada, S.; Nagano, Hitomi; Terayama, Koshi; Fujita, Masato; Kozawa, Nana; Kishimoto, Mitsuo; Yamada, Kazuo

doi:10.1007/s00261-020-02442-5

Cited by 2 publications

(1 citation statement)

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“…Imaging studies of NUC in the bladder describe irregular thickening of the wall without evidence of a defined mass and with extravesical extension 23 . The signs correspond to multiple nests at histology, with a tendency of deep infiltrative pattern sparing the surface urothelial layer 24 .…”

Section: Discussionmentioning

confidence: 99%

Metastatic upper tract urothelial carcinoma with nest‐like features presenting as malignant pleural effusion

Arienzo,

Valenti,

Ricci

et al. 2024

Diagnostic Cytopathology

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Metastatic urothelial carcinoma is a rare cause of pleural effusions. We report a case of urothelial carcinoma of the upper urinary tract in an oldest‐old male patient, a smoker, with situs inversus totalis, that presented uniquely with malignant pleural effusion at presentation without evidence of a primary tumor on imaging. Cytological smears of the massive left pleural effusion revealed epithelioid neoplastic cells arranged in short cords, small‐to‐large clusters, and raspberry‐like morules, mimicking mesothelioma; cell block preparations highlighted the presence of tubules and nest‐like structures. The tumor cells showed a high nuclear‐to‐cytoplasmic ratio, nuclear grooves, and mitotic figures. Cytomorphologic features coupled with the immunophenotype of neoplastic cells (p63, GATA3, and uroplakin II positive) allowed the diagnosis of metastatic urothelial carcinoma and a possible nested subtype. These findings were supported by a total body computed tomography (CT) showing no evidence of a mass in the bladder or elsewhere in the urinary tract but a concentric parietal thickening of the proximal left ureter, suggesting malignancy. To our knowledge, a malignant effusion as a primary manifestation of urothelial carcinoma with nest‐like features originating in the upper urinary tract has never been described previously. Our case focuses on the value of cell block in the working‐up of neoplastic effusions by revealing the architectural pattern of an uncommon malignancy and the correlation between cytopathology and imaging gross findings to reach an accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%