MRI findings at neurological onset predict neurological prognosis in hemorrhagic shock and encephalopathy syndrome

Kuki, Ichiro; Inoue, Takeshi; Nukui, Megumi; Okazaki, Shin; Kawawaki, Hisashi; Ishikawa, Junichi; Amo, Kiyoko; Togawa, Masao; Ujiro, Atsushi; Rinka, Hiroshi; Shiomi, Masashi

doi:10.1016/j.jns.2021.120010

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…Two or three of them may co-exist in very severe syndromes of acute encephalopathy. For example, hemorrhagic shock and encephalopathy syndrome shows both findings of cytokine storm such as fever, shock, DIC, and MOF ( Rinka et al, 2008 ), and those of neuronal over-excitation such as “electrical storms” on electroencephalogram (EEG), a severe form of subclinical status epilepticus ( Harden et al, 1991 ), and “bright tree appearance” on magnetic resonance imaging, cerebral subcortical lesions of reduced diffusion mimicking those of AESD ( Kuki et al, 2021 ).…”

Section: Acute Encephalopathy Syndromesmentioning

confidence: 99%

Genetic and environmental risk factors of acute infection-triggered encephalopathy

et al. 2023

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Acute encephalopathy is a constellation of syndromes in which immune response, metabolism and neuronal excitation are affected in a variable fashion. Most of the syndromes are complex disorders, caused or aggravated by multiple, genetic and environmental risk factors. Environmental factors include pathogenic microorganisms of the antecedent infection such as influenza virus, human herpesvirus-6 and enterohemorrhagic Escherichia coli, and drugs such as non-steroidal anti-inflammatory drugs, valproate and theophylline. Genetic factors include mutations such as rare variants of the SCN1A and RANBP2 genes, and polymorphisms such as thermolabile CPT2 variants and HLA genotypes. By altering immune response, metabolism or neuronal excitation, these factors complicate the pathologic process. On the other hand, some of them could provide promising targets to prevent or treat acute encephalopathy.

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Section: Acute Encephalopathy Syndromesmentioning

confidence: 99%