MRI findings of uncommon non-hepatocyte origin primary liver tumours with pathological correlation

Yc, Kim; Park, Mi‐Suk; Chung, Yong Eun; Kim, Do Young; Yn, Park; Kang, J-H; Ka, Kim

doi:10.1259/bjr/61140265

“…All eleven published cases demonstrated arterial phase enhancement (7, 10-13, 15, 17, 18), six continued to show hyperenhancement in portal venous and delayed phases (11,17,18), whereas three were hypointense (7,10,13) and two were isointense (12,15). These findings were overall consistent with our case series with all three cases demonstrating arterial phase hyperenhancement that persisted on portal venous or delayed phase imaging.…”

Section: Discussionsupporting

confidence: 87%

“…Given the confusion with BDA nomenclature in the published literature, particularly with biliary hamartomas (Von Meyenberg Complexes), articles were included if the described histologic description of BDA was specified (i.e., numerous and small ducts interspersed with fibrous stroma) (8). Our search identified 10 studies with 13 cases in total (7,(10)(11)(12)(13)(14)(15)(16)(17)(18). These results are summarized in the Table, including imaging findings from the present study.…”

Section: Methodsmentioning

confidence: 99%

Endovascular occlusion of pulmonary arteriovenous malformations with the ArtVentive Endoluminal Occlusion System™

Corvino¹,

Silvestre²,

Cervo³

et al. 2016

Diagn Interv Radiol

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PURPOSEWe aimed to evaluate the imaging features of bile duct adenoma (BDA) on ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI). METHODSRetrospective search in our institution database was performed for histologically confirmed BDA. Their imaging studies before histologic confirmation were reviewed. The search identified seven adults (mean age, 52.9 years) with histologically proven single BDA each. US (n=3), CT (n=5), and MRI (n=3) were performed before histologic confirmation. Additionally, a systematic English literature review for BDA and reported imaging findings since 2000 was also conducted using the following search criteria "bile duct adenoma, peribiliary hamartoma, biliary adenoma, CT, ultrasound, MRI" (date range: 01/01/2000 through 08/31/2016). The imaging findings of those cases reported were summarized and compared with our series. RESULTSAll seven individual nodules were well circumscribed. Five lesions were located in the right hepatic lobe and two in the left hepatic lobe. On US, lesions appeared hypoechoic (n=2) and hyperechoic (n=1). BDA was hypodense on unenhanced CT images (n=1). On MRI, BDA were hypointense on T1 (n=3), hyperintense on T2 (n=3), and hyperintense on diffusion-weighted images (n=2). On contrast-enhanced CT and MRI, BDAs showed arterial phase hyperenhancement that persisted on portal venous/delayed phase images. CONCLUSIONBDA demonstrates characteristic arterial phase hyperenhancement that persisted into the portal venous and delayed phases on CT and MRI, which may be useful in differentiating from other hepatic lesions.You may cite this article as: Chuy JA, Garg I, Graham RP, VanBuren WM, Venkatesh SK. Imaging features of bile duct adenoma: case series and review of literature. Diagn Interv Radiol 2018; 24:249-254.

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“…Adachi et al [2] 10 64/M Left lobe/4.0 Unknown + CT: heterogeneous density Fever Lateral segmentectomy Ortiz et al [11] 11 19/F Left lobe/5.5 Negative + CT: Hypovascular Abdominal fullness Left lobectomy Szekely et al [10] 12 60/M Unknown 6.0 Unknown (non-B, non-C) [7] 14 61/M S6/2.2 Unknown + Sonography: hypoechoic CT: low density w/o enhancement MR: T1 slightly hypointensity, T2 hyperintensity, progressive enhancement in periphery of the lesion…”

Section: Incidental Finding Resectionmentioning

confidence: 99%

“…Lymphoepithelioma-like carcinoma (LELC) is a tumor with morphologic features similar to those of undifferentiated nasopharyngeal carcinoma that occurs outside the nasopharynx and is associated with Epstein-Barr virus (EBV) infection. In the liver, this type of tumor is extremely rare, and only 23 cases of lymphoepitheliomalike cholangiocarcinoma have been described in reports focused on histologic and immunohistochemical analyses [1][2][3][4][5][6][7][8][9][10][11][12] . A recent study that reported seven female cases of EBV-associated lymphoepithelioma-like cholangiocarcinoma demonstrated molecular genetic pathology, including frequent DNA hypermethylation [9] .…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-like cholangiocarcinoma: A mimic of hepatocellular carcinoma on imaging features

Liao

¹

,

Liu

²

,

Chiu

³

et al. 2015

WJG

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Primary lymphoepithelioma-like carcinoma in the liver is extremely rare. A few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. We reviewed 23 cases of lymphoepithelioma-like cholangiocarcinoma reported between 1996 and 2014 and describe a rare case of a 35-year-old woman in our hospital who was diagnosed with lymphoepithelioma-like cholangiocarcinoma of the liver and was a hepatitis B carrier. The tumor (1.6 cm) in our patient appeared to be hypoechoic in sonographic images and hypodense in computed tomography (CT) images. In addition, it was homogeneous hypointense in T1-weighted magnetic resonance (MR) images (MRI) and hyperintense in T2-weighted MRI. Dynamic gadolinium-enhanced MRI showed typical image pattern of hepatocellular carcinoma (HCC). The patient underwent a laparoscopic left hepatic lobectomy, and the resected tumor consisted of well-differentiated glandular cells with extensive lymphocytic infiltration that were immunoreactive to CK (AE1/AE3), CD3, and CD20. In addition, the tumor was positive for Epstein-Barr virus-encoded RNA in situ hybridization. Finally, lymphoepithelioma-like cholangiocarcinoma was diagnosed. In previous studies, the incidence is highest among middle-aged people. Most tumors appeared to be hypodense with either hypovascular or hypervascular patterns in CT images. This case report is the first study to address sonography, CT, and MRI observations and delineate pathologic correlations. We suggest that the imaging pattern of lymphoepithelioma-like cholangiocarcinoma, either the typical cholangiocarcinoma pattern or a mimic of HCC, should be considered in the differential lists for HCC.

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“…Given the confusion with BDA nomenclature in the published literature, particularly with biliary hamartomas (Von Meyenberg Complexes), articles were included if the described histologic description of BDA was specified (i.e., numerous and small ducts interspersed with fibrous stroma) (8). Our search identified 10 studies with 13 cases in total (7,(10)(11)(12)(13)(14)(15)(16)(17)(18). These results are summarized in the Table, including imaging findings from the present study.…”

Section: Methodsmentioning

confidence: 99%

Transarterial embolization with bleomycin for symptomatic hepatic focal nodular hyperplasia

Zhang¹,

Wang²,

Duan³

et al. 2017

Diagn Interv Radiol

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PURPOSEWe aimed to evaluate the imaging features of bile duct adenoma (BDA) on ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI). METHODSRetrospective search in our institution database was performed for histologically confirmed BDA. Their imaging studies before histologic confirmation were reviewed. The search identified seven adults (mean age, 52.9 years) with histologically proven single BDA each. US (n=3), CT (n=5), and MRI (n=3) were performed before histologic confirmation. Additionally, a systematic English literature review for BDA and reported imaging findings since 2000 was also conducted using the following search criteria "bile duct adenoma, peribiliary hamartoma, biliary adenoma, CT, ultrasound, MRI" (date range: 01/01/2000 through 08/31/2016). The imaging findings of those cases reported were summarized and compared with our series. RESULTSAll seven individual nodules were well circumscribed. Five lesions were located in the right hepatic lobe and two in the left hepatic lobe. On US, lesions appeared hypoechoic (n=2) and hyperechoic (n=1). BDA was hypodense on unenhanced CT images (n=1). On MRI, BDA were hypointense on T1 (n=3), hyperintense on T2 (n=3), and hyperintense on diffusion-weighted images (n=2). On contrast-enhanced CT and MRI, BDAs showed arterial phase hyperenhancement that persisted on portal venous/delayed phase images. CONCLUSIONBDA demonstrates characteristic arterial phase hyperenhancement that persisted into the portal venous and delayed phases on CT and MRI, which may be useful in differentiating from other hepatic lesions.You may cite this article as: Chuy JA, Garg I, Graham RP, VanBuren WM, Venkatesh SK. Imaging features of bile duct adenoma: case series and review of literature. Diagn Interv Radiol 2018; 24:249-254.

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MRI findings of uncommon non-hepatocyte origin primary liver tumours with pathological correlation

Cited by 10 publications

References 18 publications

Endovascular occlusion of pulmonary arteriovenous malformations with the ArtVentive Endoluminal Occlusion System™

Endovascular occlusion of pulmonary arteriovenous malformations with the ArtVentive Endoluminal Occlusion System™

Lymphoepithelioma-like cholangiocarcinoma: A mimic of hepatocellular carcinoma on imaging features

Transarterial embolization with bleomycin for symptomatic hepatic focal nodular hyperplasia

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