MRI grading method for active and chronic spinal changes in spondyloarthritis

Madsen, Karen Berenth; Jurik, Anne Grethe

doi:10.1016/j.crad.2009.08.009

Cited by 42 publications

(44 citation statements)

References 24 publications

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“…All patients contacted the clinic because of a knee joint effusion, none received biological treatment, but all received standard disease-modifying antirheumatic drugs (DMARD). [16,17]. The methods have proven a reliable inter-and intra-observer agreement with kappa values in the range of 0.62-1.0.…”

Section: Collection Of Samplesmentioning

confidence: 94%

“…The clinical scorings comprise Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), physicians' global score on a 100-mm visual analog scale (VAS), and C-reactive protein (CRP). The radiological examinations included radiography and MRI of the SIJ and spine [16,17]. Plasma from age-and gender-matched healthy volunteers (HV) (n = 35) served as controls (Table 1).…”

Section: Collection Of Samplesmentioning

confidence: 99%

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Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings

et al. 2010

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We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA (n = 80). Furthermore, to investigate the cellular origins of the cytokines, paired mononuclear cells from blood and synovial fluid were examined for the expression of IL-17A, IL-21, and IL-23R using multicolor flow cytometry. Both IL-21 and IL-23 levels were increased in plasma from SpA patients compared with healthy volunteers (P < 0.05), whereas IL-17A was not. A significant correlation was observed between individual levels of IL-21 and IL-23 (r = 0.7, P < 0.001). No association between individual levels of IL-17A, IL-21, and IL-23 with C-reactive protein (CRP), MRI changes, and clinical scoring (BASMI, BASFI, and BASDAI) were observed. The frequency of CD4+CD45RO+ T cells expressing IL-21 and IL-23R was increased in the inflamed SpA joint compared to peripheral blood (P < 0.05). This study demonstrate that the plasma levels of the Th17-related cytokines IL-21 and IL-23, but not IL-17A, are increased in SpA patients, but we did not find evidence that the level of these cytokines reflect disease activity in SpA.

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Section: Collection Of Samplesmentioning

confidence: 94%

Section: Collection Of Samplesmentioning

confidence: 99%

Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings

et al. 2010

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“…Bone spur: Bright signal on T1-weighted images extending from the vertebral endplate towards the adjacent vertebra (spine) Ankylosis: Bright signal on T1-weighted images extending across the sacroiliac joints or extending from one vertebra being continuous with the adjacent vertebra (spine) separately or as global score Madsen and Jurik, 2010b;Østergaard et al 2009]. The validation of the methods for damage assessment is limited and their value is not yet clarified.…”

Section: B Structural Lesionsmentioning

confidence: 99%

Imaging in ankylosing spondylitis

Østergaard

Lambert

2012

Therapeutic Advances in Musculoskeletal

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Abstract:Imaging is an integral part of the management of patients with ankylosing spondylitis and axial spondyloarthritis. Characteristic radiographic and/or magnetic resonance imaging (MRI) findings are key in the diagnosis. Radiography and MRI are also useful in monitoring the disease. Radiography is the conventional, albeit quite insensitive, gold standard method for assessment of structural damage in spine and sacroiliac joints, whereas MRI has gained a decisive role in monitoring disease activity in clinical trials and practice. MRI may also, if ongoing research demonstrates a sufficient reliability and sensitivity to change, become a new standard method for assessment of structural damage. Ultrasonography allows visualization of peripheral arthritis and enthesitis, but has no role in the assessment of axial manifestations. Computed tomography is a sensitive method for assessment of structural changes in the spine and sacroiliac joints, but its clinical utility is limited due to its use of ionizing radiation and lack of ability to assess the soft tissues. It is exciting that with continued dedicated research and the rapid technical development it is likely that even larger improvements in the use of imaging may occur in the decade to come, for the benefit of our patients.

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“…Also in the spine, the level of detail in the proposed MRI assessment systems has varied markedly. Most scoring systems have provided a "global" score of each discovertebral unit (DVU) 12,13 , whereas more recently the Canada-Denmark method, in addition to providing detailed definitions of inflammatory and structural pathologies 14,15 , also defined a number of distinct anatomical locations (e.g., anterior and posterior corners of the vertebrae and the facet joints) of each DVU, where these pathologies could be evaluated 16,17 . Subsequently, the assessment of the structural components has been developed into scoring systems of fat (The Fat Spondyloarthritis Spine Score) 18 and bone proliferation 19 .…”

mentioning

confidence: 99%