MRI-Guided Therapy

Fast, interleaved, Look‐Locker–based T1 mapping with a variable averaging approach: Towards temperature mapping at low magnetic field

“…Providing images with unparalleled soft tissue contrast, magnetic resonance imaging (MRI) has become a major contender in IGT, because of its inherent absence of ionizing radiations and the possibility to complement anatomical images with quantitative physiological information (e.g., blood flow, diffusion/perfusion, stiffness). Over roughly three decades, interventional and intraoperative MRI have been leveraged for navigation, motion tracking during intraoperative and biopsy procedures, 1,2 and for real time or quasi‐real time feedback for MR theragnostic methods (e.g., MR‐guided high intensity focused ultrasound surgery, radiofrequency [RF] hyperthermia, radiation, and proton therapy) 3 . The continuous evolution of MRI towards higher magnetic fields also contributed to boosting the appeal of this imaging modality among clinicians, considering the higher level of detail achievable with the promise of reduced scan times 4 .…”

“…Over roughly three decades, interventional and intraoperative MRI have been leveraged for navigation, motion tracking during intraoperative and biopsy procedures, 1 , 2 and for real time or quasi‐real time feedback for MR theragnostic methods (e.g., MR‐guided high intensity focused ultrasound surgery, radiofrequency [RF] hyperthermia, radiation, and proton therapy). 3 The continuous evolution of MRI towards higher magnetic fields also contributed to boosting the appeal of this imaging modality among clinicians, considering the higher level of detail achievable with the promise of reduced scan times. 4 Nonetheless, such benefits come at the price of lowered compatibility with the settings and procedures typical of an operating room.…”

Isotopomeric Elucidation of the Mechanism of Temperature Sensitivity in 59Co NMR Molecular Thermometers

“…Environmentally sensitive nuclear spins offer a route to novel magnetic resonance imaging agents or quantum-sensing molecular platforms. , One such environmental stimulus of interest is temperature because noninvasive thermometry could enable guided thermal therapies and imaging. − Cobalt-59 ( 59 Co) nuclear spins are highly promising for this application because of the strong temperature dependence of the 59 Co chemical shift, δ. − The current record for the sensitivity of the chemical shift to temperature (Δδ/Δ T ) from a 59 Co nucleus is 3.15 ppm/°C in Co­(acac) 3 . Higher sensitivities are ultimately necessary for utility, yet the precise molecular factors (specifically, ligand identity) that control Δδ/Δ T are unknown.…”