MRI in Animal Models of Psychiatric Disorders

Poole, Dana S.; Oitzl, Melly S.; Weerd, Louise van der

doi:10.1007/978-1-61779-219-9_17

Cited by 3 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adaptation of neuroimaging to rodents has enabled researches to observe in vivo longitudinal changes at the organ, cell, and molecular levels (Lancelot and Zimmer, 2010; Poole et al, 2011). Magnetic resonance imaging (MRI) has been used to assess volumetric changes in the lateral ventricles and brain regions in several animal models for schizophrenia (Denic et al, 2011; Dijkhuizen and Nicolay, 2003; Hikida et al, 2007; Pletnikov et al, 2008).…”

Section: Endophenotypes In Animal Models For Gei In Schizophreniamentioning

confidence: 99%

Mouse models of gene–environment interactions in schizophrenia

Kannan

Sawa

Pletnikov

2013

Neurobiology of Disease

View full text Add to dashboard Cite

Gene-environment interactions (GEI) likely play significant roles in the pathogenesis of schizophrenia and underlie differences in pathological, behavioral, and clinical presentations of the disease. Findings from epidemiology and psychiatric genetics have assisted in the generation of animal models of GEI relevant to schizophrenia. These models may provide a foundation for elucidating the molecular, cellular, and circuitry mechanisms that mediate GEI in schizophrenia. Here we critically review current mouse models of GEI related to schizophrenia, describe directions for their improvement, and propose endophenotypes provide a more tangible basis for molecular studies of pathways of GEI and facilitate the identification of novel therapeutic targets.

show abstract

Section: Endophenotypes In Animal Models For Gei In Schizophreniamentioning

confidence: 99%

Mouse models of gene–environment interactions in schizophrenia

Kannan

Sawa

Pletnikov

2013

Neurobiology of Disease

View full text Add to dashboard Cite

show abstract

“…Examples include Huntington's disease [28][29][30][31], Alzheimer's disease [32][33][34], and other mental health diseases like schizophrenia [35,36], and recently, autism [37][38][39]. Genetic knockouts are also examined to identify the role of specific genes in development, behaviour and aging.…”

Section: Magnetic Resonance Imaging In the Mousementioning

confidence: 99%

Magnetic Resonance Imaging as a Tool for the Study of Mouse Models of Autism

Ellegood¹,

Henkelman²,

Lerch³

2012

Autism

View full text Add to dashboard Cite

Autism is a heterogeneous disorder, in both its behaviour and genetics. This heterogeneity has led to inconsistencies in the neuroanatomical findings in human autistic patients. The benefit of a model system, such as the mouse, is that there could be a decrease in the heterogeneity of the genetics and standardization of the environment could be done, in order to determine a specific anatomical phenotype, which is representative of a specific genotype. Magnetic Resonance Imaging (MRI) has been used quite extensively to examine morphological changes in the mouse brain; however, examining volume and tissue microstructure changes in mouse models of autism with MRI, is just in its infancy. This review will discuss the current research on anatomical phenotyping in mouse models of autism. AutismAnimal Models in Autism

show abstract