MRI in assessment of lung cancer

Hochhegger, Bruno; Marchiori, Edson; Irion, Klaus; Moreira, José da Silva; Zanetti, Gláucia

doi:10.1136/thx.2011.159111

Cited by 9 publications

(5 citation statements)

References 9 publications

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“…Previous investigators’ findings are in accordance with our results [54, 55]. Future technical improvements may overcome this limitation [56, 57].…”

Section: Discussionsupporting

confidence: 93%

Speeding up PET/MR for cancer staging of children and young adults

et al. 2016

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Objective Combining 18F-FDG PET with whole-body MR for paediatric cancer staging is practically feasible if imaging protocols can be streamlined. We compared 18F-FDG PET/STIR with accelerated 18F-FDG PET/FSPGR for whole-body tumour imaging in children and young adults. Methods Thirty-three children and young adults (17.5±5.5 years, range 10–30 years) with malignant lymphoma or sarcoma underwent a 18F-FDG PET staging exam, followed by ferumoxytol-enhanced STIR and FSPGR whole-body MR. 18F-FDG PET scans were fused with MR data and the number and location of tumours on each integrated exam was determined. Histopathology and follow-up imaging served as standard of reference. The agreement of each MR sequence with the reference and the whole-body imaging times were compared using Cohen’s kappa coefficient and student t-test, respectively. Results Comparing 18F-FDG PET/FSPGR to 18F-FDG PET/STIR, sensitivities were 99.3% for both, specificities were statistically equivalent, 99.8% versus 99.9% and the agreement with the reference based on Cohen’s kappa coefficient was also statistically equivalent, 0.989 versus 0.992. However, the total scan-time for accelerated FSPGR of 19.8±5.3 minutes was significantly shorter compared to 29.0±7.6 minutes for STIR (p=0.001). Conclusion 18F-FDG PET/FSPGR demonstrated equivalent sensitivities and specificities for cancer staging compared to 18F-FDG PET/STIR, but could be acquired with shorter acquisition time.

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“…Previous investigators’ findings are in accordance with our results [54, 55]. Future technical improvements may overcome this limitation [56, 57].…”

Section: Discussionsupporting

confidence: 93%

Speeding up PET/MR for cancer staging of children and young adults

et al. 2016

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“…Interventional radiologists’ ability to collect tissue specimens that are representative of tumor aggressiveness is thus increasingly important. Functional imaging methods, such as DWI and PET/CT, are key to the effectiveness of image-guided percutaneous biopsies, obviating more invasive procedures for proper diagnosis and therapeutic planning [5,13]. In the present study, all biopsies were performed under functional imaging guidance, including PET/CT and DWI, and provided adequate material for analyses.…”

Section: Discussionmentioning

confidence: 99%

Functional imaging with diffusion-weighted MRI for lung biopsy planning: initial experience

et al. 2014

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BackgroundThe purpose of this study was to evaluate the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) and positron emission tomography/computed tomography (PET/CT) in planning transthoracic CT-guided biopsies of lung lesions.MethodsThirteen patients with lung lesions suspicious for malignancy underwent CT-guided biopsy. Chest DW-MRI and apparent diffusion coefficient (ADC) calculation were performed to aid biopsy planning with fused images. MRI was indicated due to large heterogeneous masses, association with lung atelectasis/consolidation/necrosis, and/or divergent results of other biopsy type and histopathology versus clinical/radiological suspicion. Eight patients underwent PET/CT to identify appropriate areas for biopsy.ResultsMean patient (n = 9 males) age was 59 (range, 30 to 78) years. Based on DW-MRI results, biopsies targeted the most suspicious areas within lesions. All biopsied areas showed higher DW signal intensity and lower ADCs (mean, 0.79 (range, 0.54 to 1.2) × 10−3 mm2/s), suggesting high cellularity. In patients who underwent PET/CT, areas with higher 18-fluorodeoxyglucose concentrations (standard uptake value mean, 7.7 (range, 3.6 to 13.7)) corresponded to areas of higher DW signal intensity and lower ADCs. All biopsies yielded adequate material for histopathological diagnosis.ConclusionsFunctional imaging is useful for lung biopsy planning. DW-MRI and PET/CT increase overall performance and enable the collection of adequate material for specific diagnosis.

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“…Recent technological advances have substantially improved the sensitivity of MRI for the detection of pulmonary nodules [79, 80]. However, to date, MRI scans, with or without integrated FDG-PET information, do not yet reach the sensitivity of a CT scan.…”

Section: Solve the Pulmonary Nodule Detection Dilemmamentioning

confidence: 99%

How PET/MR Can Add Value for Children with Cancer

Daldrup-Link

2017

Curr Radiol Rep

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Purpose To review how PET/MR technology could add value for pediatric cancer patients. Recent Findings Since many primary tumors in children are evaluated with MRI and metastases are detected with PET/CT, integrated PET/MR can be a time-efficient and convenient solution for pediatric cancer staging. 18F-FDG PET/MR can assess primary tumors and the whole body in one imaging session, avoid repetitive anesthesia and reduce radiation exposure compared to 18F-FDG PET/CT. This article lists 10 action points, which might improve the clinical value of PET/MR for children with cancer. However, even if PET/MR proves valuable, it cannot enter mainstream applications if it is not accessible to the majority of pediatric cancer patients. Therefore, innovations are needed to make PET/MR scanners affordable and increase patient throughput. Summary PET/MR offers opportunities for more efficient, accurate and safe diagnoses of pediatric cancer patients. The impact on patient management and outcomes has to be substantiated by large-scale prospective clinical trials.

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MRI in assessment of lung cancer

Cited by 9 publications

References 9 publications

Speeding up PET/MR for cancer staging of children and young adults

Speeding up PET/MR for cancer staging of children and young adults

Functional imaging with diffusion-weighted MRI for lung biopsy planning: initial experience

How PET/MR Can Add Value for Children with Cancer

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