MRI in Multiple Sclerosis

Abstract

The diagnosis of Multiple Sclerosis (MS) is based on clinical findings that are characterized by sudden neurological deficits in different parts of the CNS. Dissemination of lesions in space and time is the basic criterion. MRI can demonstrate most precisely any changes in the water content of brain tissue thus making it a very sensitive diagnostic tool to detect inflammatory processes like MS plaques. The following will briefly summarize the diagnostic features and procedures and will assess the appearance of typical MS lesions, their localization and configuration, which are essential for diagnosis and follow up examinations. It will propose the preferred sequences and technical parameters for standardized baseline examinations and follow-ups.

Influence of natalizumab on resting-state connectivity in patients with multiple sclerosis

“…1 Brain MRI is fundamental for MS diagnosis. MRI is used to visualize the distribution of the disease in the CNS over time, to exclude other conditions, 2,8 and to monitor disease evolution, and treatment effects. 9 However, the association between conventional neuroradiological markers of MS and clinical disability has been weak due to several factors.…”

“…Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS), which leads to widespread brain and spinal cord lesions, 1 , 2 with early inflammation, causing relapsing–remitting disease and delayed neurodegeneration causing nonrelapsing progression. 3 The current therapeutic strategies for MS aims to reduce the risk of relapse and disability progression.…”