MRI in the study of distal primary myopathopies and of muscular alterations due to peripheral neuropathies: possible diagnostic capacities of MR equipment with low intensity field (0.2 T) dedicated to peripheral limbs

Messineo, Daniela; Cremona, Antonio; Trinci, Margherita; Francia, Ada; Marini, Andrea

doi:10.1016/s0730-725x(98)00080-0

Cited by 17 publications

(18 citation statements)

References 21 publications

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“…These results show that MRI allows detection and evaluation of three-dimensional local reactions within muscular and subcutaneous tissues caused by the injection of vaccines. These data, obtained in pigs, are in line with results of human studies, where MRI has been used to detect and monitor muscular damage (Fisher et al, 1986;Lovitt et al, 2006;Messineo et al, 1998;Schrank et al, 2005).…”

Section: Discussionsupporting

confidence: 85%

“…These abnormalities effect an alteration in tissue parameters and cause differences in signal intensity in the image, as well as in muscle size and profile (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). The ability to detect these alterations makes MRI a useful tool in diagnosis and follow-up of musculoskeletal diseases in humans (Lovitt et al, 2006;Messineo et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Bernau

Kremer

Pappenberger

et al. 2015

ALTEX

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SummarySafety testing of veterinary vaccines requires the use of a large number of animals to investigate possible local and systemic reactions. This includes, among others, the pathological examination of the injection site in frequent intervals. This examination requires a selected killing of animals in frequent intervals. To reduce the number of animals needed for this kind of safety testing, magnetic resonance imaging (MRI) was used to detect and quantify possible local reactions after vaccination in vivo. Sixty-four pigs were divided into four experimental groups (n = 16); two groups consisting of 12-week-old pigs and two of 6-month-old pigs at vaccination day. The pigs were vaccinated with four licensed products (each group receiving one vaccine) and examined up to 6 times using MRI during a period of 5 weeks. The MR images were evaluated semi-automatically, comparing the volumes of altered signal intensities on the vaccination side (VS) with the volumes of the signal intensities on the control side (CS). A paired t-test was used to identify significant differences (p < 0.05) between VS and CS. The results show that MRI allows a 3D-quantification of the extent of local reactions in vivo by scanning the same live animals at several time points after vaccination. MRI is a suitable alternative method for non-invasive safety testing of injectable medicines and can therefore be applied to reduce animal numbers used for safety testing purposes.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Bernau

Kremer

Pappenberger

et al. 2015

ALTEX

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“…The anterior compartments of the lower legs were well-preserved on MRI in contrast to the calfs. One patient (13)(14)(15)(16)(17)(18)(19) showed ankle plantar flexor and dorsiflexor edema. Edematous skeletal muscle changes were not present in all remaining 14 DM2 patients.…”

Section: ■ Clinical Data (Table1 )mentioning

confidence: 99%

Distinct neuromuscular phenotypes in myotonic dystrophy types 1 and 2

et al. 2006

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Myotonic Dystrophy Type 1 (DM1) and 2 (DM2) present with distinct though overlapping clinical phenotypes. Comparative imaging data on skeletal muscle involvement are not at present available. We used the novel technique of whole body 3.0 Tesla (T) Magnetic Resonance Imaging (MRI) to further characterize musculoskeletal features in DM2 and compared the results with DM1.MRI findings of 15 DM1 and 14 DM2 patients were evaluated with respect to patterns of skeletal muscle affection and clinical data using the Muscular Impairment Rating Scale (MIRS) and Medical Research Council scale (MRC). All DM1 patients had pathological MRI compared with only 5 DM2 patients. In contrast to DM2, DM1 patients showed a characteristic distribution of muscle involvement with frequent and early degeneration of the medial heads of gastrocnemius muscles, and a perifemoral semilunar pattern of quadriceps muscle affection sparing the rectus femoris. The most frequently affected muscles in DM1 were the medial heads of gastrocnemius, soleus, and vastus medialis muscles. In DM2, however, the erector spinae and gluteus maximus muscles were most vulnerable to degeneration. MRI data were in line with the clinical grading in 12 DM1 and 3 DM2 patients. In 3 DM1 and 5 DM2 patients, MRI detected subclinical muscle involvement. 9 DM2 patients with mild to moderate proximal muscle weakness and/or myalgias had normal MRI. Pathological MRI changes in DM2 emerged with increasing age and were restricted to women. Whole body 3.0T MRI is a sensitive imaging technique that demonstrated a characteristic skeletal muscle affection in DM1. In contrast, MRI was no reliable indicator for skeletal muscle involvement in mildly affected DM2 patients since myalgia and mild paresis were usually not reflected by MRI signal alterations.

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“…Since some of muscular diseases affect certain muscles in different body regions, screening the skeletal muscular system to map the areas affected by disease is perhaps the greatest contribution whole-body MR muscle screening has made to the study of muscular disease. The previous MR muscle studies are concentrated at the lower limb area without giving information on the other body parts [4][5][6][7][8]. Recently published reports on quantitative MR evaluation of body compositions in patients with muscular dystrophy cover comparable regions as in presented whole-body MR screening schemes; however, these studies only concentrated on the quantitative analysis of body fat compositions, without giving the value of different muscle involvement patterns in the evaluation of various neuromuscular diseases [11,12].…”

Section: Discussionmentioning

confidence: 99%

“…However, the clinical application of CT is limited due to the use of ionizing radiation and the artifacts from dense bone structures. Recent studies have also shown the value of MRI in the evaluation of neuromuscular disease [4][5][6][7][8]. However, these studies are based on only one anatomic region and obtain limited information about the disease extension.…”

Section: Introductionmentioning

confidence: 99%