MRI in uterine cancers with uncertain origin: Endometrial or cervical? Radiological point of view with review of the literature

Gui, Benedetta; Lupinelli, Michela; Russo, Leila; Miccò, Maura; Avesani, Giacomo; Panico, Camilla; Paola, Valerio Di; Rodolfino, Elena; Autorino, Riccardo; Ferrandina, G.; Fanfani, Francesco; Manfredi, Roberto

doi:10.1016/j.ejrad.2022.110357

Cited by 11 publications

(2 citation statements)

References 37 publications

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“…While endometrium cancer may spread to the cervical canal and cervical stroma, cervical cancer can spread to the endometrial cavity and myometrium. As a result, clinical examination alone is unreliable due to its limited diagnostic accuracy in determining the origin of the primary tumor 12 .…”

Section: Discussionmentioning

confidence: 99%

Unusual spread of cervical adenocarcinoma to the endometrium and left fallopian tube: a case report and literature review

Zeer,

Jawaada,

Bannoura

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: The incidence of cervical adenocarcinoma and adenocarcinoma in situ are gradually increasing especially in younger women. However, unusual spread of cervical adenocarcinoma has rarely been reported. Case Presentation: We report a case of a 60-year-old woman who presented with postmenopausal bleeding. She was misdiagnosed to have endometrial adenocarcinoma on the lower uterine segment depending on curettage specimen. After hysterectomy, it was revealed depending on morphological features in histology accompanied with immunohistochemistry that the patient had cervical adenocarcinoma with endometrial and left fallopian tube extension. Discussion: Distinguishing endocervical adenocarcinoma from endometroid adenocarcinoma poses many challenges especially when evaluating endometrial curettage specimens. Histological diagnosis based on morphological features combined with a panel of immunohistochemistry stains is crucial for accurate diagnosis and identifying the primary origin of the tumor. Conclusion: Accurate distinction between cervical adenocarcinoma versus endometrial adenocarcinoma is important because of its significant effects on choosing the appropriate treatment option.

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Section: Discussionmentioning

confidence: 99%

Unusual spread of cervical adenocarcinoma to the endometrium and left fallopian tube: a case report and literature review

Zeer,

Jawaada,

Bannoura

et al. 2024

Annals of Medicine &Amp; Surgery

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“…Diffusion-weighted imaging (DWI) reflects the restricted diffusion and movement of water molecules in tumour tissue and has been relatively maturely used in EC pathological features and prognostic evaluation indicators (18,19). Fat quantitation imaging (mDixon-Quant) based on chemical-shift encoding water-fat separation allows mapping of transverse relaxation rate (R2*) and fat fraction (FF), which reflect information on the paramagnetic material and fat content in tissues (20,21).…”

Section: Introductionmentioning

confidence: 99%

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

Shifeng,

Yue,

Wen

et al. 2023

Acta Radiol

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Background Endometrial carcinoma (EC) is the sixth most common cancer in women. P53 gene expression in patients with endometrial cancer can predict the efficacy and prognosis of patients with neoadjuvant therapy. Purpose To explore the value of multimodal magnetic resonance imaging (MRI) in differentiating p53 abnormal (p53abn) from p53 wild-type (p53wt) EC. Material and Methods Data from 47 EC patients, including 14 p53abn cases and 33 p53wt cases, were retrospectively analyzed. The preoperative MRI sequences included amide proton transfer weighted (APTw) imaging, T2 mapping, mDIXON-Quant imaging and diffusion-weighted imaging (DWI). After post-processing, APT, T2, transverse relaxation rate (R2*), fat fraction (FF) and apparent diffusion coefficient (ADC) maps were obtained. The APT, T2, R2*, FF and ADC values for lesions of the two groups of cases were measured by two observers who were blind to the pathological data. Results The APT value and R2* value in the p53abn group were higher than those in the p53wt group, while the ADC value was lower (all P < 0.05). There was no statistically significant difference in T2 value and FF value between the two groups (all P > 0.05). The area under curve of APT, R2*, ADC and combined APT + R2*+ADC values for identification of p53abn and p53wt EC were 0.739, 0.689, 0.718 and 0.820, respectively (all P > 0.05). Conclusion APTw, mDIXON-Quant and DWI techniques can be usedfor quantitative identification of p53abn and p53wt EC. The multimodal MRI provides a new way for preoperative quantitative evaluation of EC molecular typing, which has certain clinical application value.

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Multiparametric MRI-based radiomics nomogram for identifying cervix-corpus junction cervical adenocarcinoma from endometrioid adenocarcinoma

Fang,

Wang,

Xiao

et al. 2024

Abdom Radiol

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MRI in uterine cancers with uncertain origin: Endometrial or cervical? Radiological point of view with review of the literature

Cited by 11 publications

References 37 publications

Unusual spread of cervical adenocarcinoma to the endometrium and left fallopian tube: a case report and literature review

Unusual spread of cervical adenocarcinoma to the endometrium and left fallopian tube: a case report and literature review

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

Multiparametric MRI-based radiomics nomogram for identifying cervix-corpus junction cervical adenocarcinoma from endometrioid adenocarcinoma

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