MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Tapiola, Tero; Pennanen, Corina; Tapiola, Mia; Tervo, Susanna; Kivipelto, Miia; Hänninen, Tuomo; Pihlajamäki, Maija; Laakso, Mikko P.; Hallikainen, Merja; Hämäläinen, Anne; Vanhanen, Matti; Helkala, Eeva‐Liisa; Vanninen, Ritva; Nissinen, Aulikki; Rossi, Roberta; Frisoni, Giovanni B.; Soininen, Hilkka

doi:10.1016/j.neurobiolaging.2006.09.007

Cited by 143 publications

(109 citation statements)

References 38 publications

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“…However, this and other results should be considered with caution owing to the relatively small number of converters. Anyway, this is in agreement with several studies regarding the manual segmentation of hippocampus, which have reported that baseline hippocampal volume is an indicator of future progression to AD [21,[70][71][72][73]. This is also in agreement with studies based on visual rating, which clearly found MTL atrophy in patients who subsequently converted to AD [74][75][76].…”

Section: Yushkevich Et Alsupporting

confidence: 92%

Automatic Morphological Analysis of Medial Temporal Lobe

Chincarini¹,

Corosu²,

Gemme³

et al. 2010

TONMEDJ

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Abstract:Research in Alzheimer's disease (AD) has seen a tremendous growth of candidate biomarkers in the last decade. The role of such established or putative biomarkers is to allow an accurate diagnosis of AD, to infer about its prognosis, to monitor disease progression and evaluate changes induced by disease-modifying drugs. An ideal biomarker should detect a specific pathophysiological feature of AD, not present in the healthy condition, in other primary dementias, or in confounding conditions. Besides being reliable, a biomarker should be detectable by means of procedures which must be relatively non-invasive, simple to perform, widely available and not too expensive. At present, no candidate meets these requirements representing the high standards aimed at by researchers. Among others, various morphological brain measures performed by means of magnetic resonance imaging (MRI), ranging from the total brain volume to some restricted regions such as the hippocampal volume, have been proposed. Nowadays the efforts are directed toward finding an automated, unsupervised method of evaluating atrophy in some specific brain region, such as the medial temporal lobe (MTL). In this work we provide an extensive review of the state of the art on the automatic and semi-automatic image processing techniques for the early assessment of patients at risk of developing AD. Our main focus is the relevance of the morphological analysis of MTL, and in particular of the hippocampal formation, in making the diagnosis of AD and in distinguishing it from other dementias.

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Section: Yushkevich Et Alsupporting

confidence: 92%

Automatic Morphological Analysis of Medial Temporal Lobe

Chincarini¹,

Corosu²,

Gemme³

et al. 2010

TONMEDJ

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“…White matter lesion, one of the main pathological consequence of CCH, is also influenced by APOE genotype (Tapiola et al, 2008). Furthermore, CSF levels of APOE decreased with increasing degree of white matter lesion (Skoog et al, 1997).…”

Section: Apoe-mediated Synaptic Effects Of Chronic Cerebral Hypoperfumentioning

confidence: 99%

Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex

et al. 2017

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Chronic cerebral hypoperfusion (CCH) evokes mild cognitive impairment (MCI) and contributes to the progression of vascular dementia and Alzheimer's disease (AD). How CCH 2 induces these neurodegenerative processes that may spread along the synaptic network and whether they are detectable at the synaptic proteome level of the cerebral cortex remains to be established.In the present study, we report the synaptic protein changes in the cerebral cortex after stepwise bilateral common carotid artery occlusion (BCCAO) induced CCH in the rat. The occlusions were confirmed with Magnetic Resonance Angiography 5 weeks after the surgery.Synaptosome fractions were prepared using sucrose gradient centrifugation from cerebral cortex dissected 7 weeks after the occlusion. The synaptic protein differences between the sham operated and CCH groups were analysed with label free nanoUHPLC-MS/MS.

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“…Neuroimaging may permit exclusion of vascular pathology, detection of hippocampal atrophy and cerebral hypoperfusion (Tapiola et al, 2008;Xu et al, 2007). It must be noted that first AD lesions may coexist with vascular dementia in at least 50 % of cases.…”

Section: Which Techniques Could Be Applied?mentioning

confidence: 99%