MRI of normal fetal brain development

Prayer, Daniela; Kasprian, Gregor; Krampl, Elisabeth; Ulm, Barbara; Witzani, L.; Prayer, L.; Brugger, Peter C.

doi:10.1016/j.ejrad.2005.11.020

Cited by 205 publications

(154 citation statements)

References 106 publications

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“…11,13 These periventricular crossroad regions become detectable from 20 weeks' gestation histologically 13 and 24 Note:-MRI ϭ MR imaging. weeks on fetal MR imaging 15 and remain visible at term gestation in many infants. Thus, the presence of this signal-intensity characteristic on our images was separately noted as visible or invisible.…”

Section: Discussionmentioning

confidence: 99%

High Signal Intensity on T2-Weighted MR Imaging at Term-Equivalent Age in Preterm Infants Does Not Predict 2-Year Neurodevelopmental Outcomes

Kidokoro

Anderson

Doyle

et al. 2011

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

High Signal Intensity on T2-Weighted MR Imaging at Term-Equivalent Age in Preterm Infants Does Not Predict 2-Year Neurodevelopmental Outcomes

Kidokoro

Anderson

Doyle

et al. 2011

AJNR Am J Neuroradiol

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“…20 We explored a range of clip lengths Յ12 minutes; the number of clips varied depending on the available scanning time. The effect of temporal resolution on the accurate representation of movements was tested by using video recordings of 2 term-age neonates lasting 60 seconds each and shot at 25 fps.…”

Section: Bssfp Optimizationmentioning

confidence: 99%

Optimization and Initial Experience of a Multisection Balanced Steady-State Free Precession Cine Sequence for the Assessment of Fetal Behavior in Utero

Hayat¹,

Nihat²,

Martinez‐Biarge³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The assessment of motor function is an essential component of neurologic examinations, which imaging studies have extended to the fetus. US assessment is hampered by a limited FOV, whereas MR imaging has the potential to be an alternative. Our objectives were to optimize a cine MR imaging sequence for capturing fetal movements and to perform a pilot analysis of the relationship between the frequency of movements and uterine spatial constrictions in healthy fetuses.

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“…Either a body coil or a phase-arrayed surface coil typically is used for scanning the human fetus (Huisman et al, 2002;Prayer et al, 2006). A body coil in transmitter and receiver mode provided inadequate SNR (Fig.…”

Section: Radiofrequency Coilsmentioning

confidence: 99%

Study of the development of fetal baboon brain using magnetic resonance imaging at 3 Tesla

et al. 2008

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Direct observational data on the development of the brains of human and nonhuman primates is on remarkably scant, and most of our understanding of primate brain development is extrapolated from findings in rodent models. Magnetic resonance imaging (MRI) is a promising tool for the noninvasive, longitudinal study of the developing primate brain. We devised a protocol to scan pregnant baboons serially at 3 T for up to 3 h per session. Seven baboons were scanned 1-6 times, beginning as early as 56 days post-conceptional age, and as late as 185 days (term ~185 days). Successful scanning of the fetal baboon required careful animal preparation and anesthesia, in addition to optimization of the scanning protocol. We successfully acquired maps of relaxation times (T 1 and T 2 ) and high-resolution anatomical images of the brains of fetal baboons at multiple time points during the course of gestation. These images demonstrated the convergence of gray and white matter contrast near term, and furthermore demonstrated that the loss of contrast at that age is a consequence of the continuous change in relaxation times during fetal brain development. These data furthermore demonstrate that maps of relaxation times have clear advantages over the relaxation time weighted images for the tracking of the changes in brain structure during fetal development. This protocol for in utero MRI of fetal baboon brains will help to advance the use of nonhuman primate models to study fetal brain development longitudinally.

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MRI of normal fetal brain development

Cited by 205 publications

References 106 publications

High Signal Intensity on T2-Weighted MR Imaging at Term-Equivalent Age in Preterm Infants Does Not Predict 2-Year Neurodevelopmental Outcomes

High Signal Intensity on T2-Weighted MR Imaging at Term-Equivalent Age in Preterm Infants Does Not Predict 2-Year Neurodevelopmental Outcomes

Optimization and Initial Experience of a Multisection Balanced Steady-State Free Precession Cine Sequence for the Assessment of Fetal Behavior in Utero

Study of the development of fetal baboon brain using magnetic resonance imaging at 3 Tesla

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