MRI of the lung (1/3): methods

Wild, Jim M.; Marshall, Helen; Bock, Michael; Schad, Lothar R.; Jakob, Peter M.; Puderbach, Michael; Molinari, Francesco; Beek, Edwin Jacques Rudolph van; Biederer, Jürgen

doi:10.1007/s13244-012-0176-x

Cited by 217 publications

(182 citation statements)

References 31 publications

Supporting

Mentioning

178

Contrasting

Unclassified

Order By: Relevance

“…As a matter of fact, tumor signal enhancement using gadolinium-based contrast agents is a common approach in clinical and preclinical MRI for improving the detection and the delineation of cancerous tissue (20,23,32). However, contrast enhancement of tumors located in the lung can be severely hampered by motion artifacts and unmatched magnetic susceptibility between air and tissues (6,7,(10)(11)(12). In addition, for this organ, airway delivery of diagnostic or therapeutic compounds might be an efficient (yet unexplored) route for targeting lung tumors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Targeting and in vivo imaging of non-small–cell lung cancer using nebulized multimodal contrast agents

Bianchi

Dufort

Lux

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

One of the main reasons for the dismal prognosis of lung cancer is related to the late diagnosis of this pathology. In this work, we evaluated the potential of optimized lung MRI techniques and nebulized ultrasmall multimodal gadolinium-based contrast agents [ultrasmall rigid platforms (USRPs)] as a completely noninvasive approach for non-small-cell lung cancer (NSCLC) in vivo detection. A mouse model of NSCLC expressing the luciferase gene was developed. Ultrashort echo-time free-breathing MRI acquisitions were performed before and after i.v. or intrapulmonary administration of the nanoparticles to identify and segment the tumor. After orotracheal or i.v. administration of USRPs, an excellent colocalization of the position the tumor with MRI, bioluminescence and fluorescence reflectance imaging, and histology was observed in all mice. Significantly higher signal enhancements and contrast-to-noise ratios were observed with orotracheal administration using lower doses, reducing the toxicity issues and the interobserver variability in tumor detection. The observations suggested the existence of an unknown original mechanism (different from the enhanced permeability and retention effect) responsible for this phenomenon. MRI and USRPs were shown to be powerful imaging tools able to detect, quantify, and longitudinally monitor the development of submillimetric NSCLCs. The absence of ionizing radiation and high resolution MRI, along with the complete noninvasiveness and good reproducibility of the proposed protocol, make this technique potentially translatable to humans. To our knowledge this is the first time that the advantages of an orotracheal administration route are demonstrated for the investigation of the pathomorphological changes due to NSCLCs. lung tumor | magnetic resonance imaging | bioluminescence imaging | gadolinium-based nanoparticles

show abstract

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, this consideration cannot yet be applied to the lung, which remains one of the most difficult organs to image with MRI because of its intrinsic properties (motion artifacts, low proton density, numerous susceptibility gradients) (6,7,(10)(11)(12).…”

mentioning

confidence: 99%

Targeting and in vivo imaging of non-small–cell lung cancer using nebulized multimodal contrast agents

Bianchi

Dufort

Lux

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…2012). The technique's applicability is potentially limited by confounding factors in the form of venous signal and image misregistration, and by potential sampling bias from imaging a small portion of the lung volume.…”

Section: Discussionmentioning

confidence: 99%

In silico modeling of oxygen-enhanced MRI of specific ventilation

et al. 2018

View full text Add to dashboard Cite

Specific ventilation imaging (SVI) proposes that using oxygen‐enhanced 1H MRI to capture signal change as subjects alternatively breathe room air and 100% O2 provides an estimate of specific ventilation distribution in the lung. How well this technique measures SV and the effect of currently adopted approaches of the technique on resulting SV measurement is open for further exploration. We investigated (1) How well does imaging a single sagittal lung slice represent whole lung SV? (2) What is the influence of pulmonary venous blood on the measured MRI signal and resultant SVI measure? and (3) How does inclusion of misaligned images affect SVI measurement? In this study, we utilized two patient‐based in silico models of ventilation, perfusion, and gas exchange to address these questions for normal healthy lungs. Simulation results from the two healthy young subjects show that imaging a single slice is generally representative of whole lung SV distribution, with a calculated SV gradient within 90% of that calculated for whole lung distributions. Contribution of O2 from the venous circulation results in overestimation of SV at a regional level where major pulmonary veins cross the imaging plane, resulting in a 10% increase in SV gradient for the imaging slice. A worst‐case scenario simulation of image misalignment increased the SV gradient by 11.4% for the imaged slice.

show abstract

“…[1]). Even for acquisitions at end-expiratory breathholding (FRC), the two datasets will show small but unavoidable differences in the breath-hold positions, yielding volume-related signal modulations which are on the same order of magnitude as the oxygen-related signal increase.…”

Section: Signal Intensity Variability At Functional Residual Capacitymentioning

confidence: 99%

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Pusterla

Bauman

Bieri

2017

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose: To assess the feasibility of 3D oxygen-enhanced (OE) MRI of the lung at 1.5T using multi-volumetric ultra-fast balanced steady-state free precession (ufSSFP) acquisitions. Methods: Isotropic imaging of the lung for OE-MRI was performed with an adapted 3D ufSSFP sequence using five breathhold acquisitions ranging from functional residual capacity to tidal inspiration under both normoxic (room air) and hyperoxic (100% O 2 ) gas conditions. For each O 2 concentration, a sponge model (which captures the parenchymal signal intensity variation as a function of the lung volume) was fitted to the acquired multivolumetric datasets after semiautomatic lung segmentation and deformable image registration. From the retrieved model parameters, 3D oxygen-enhancement maps were calculated. Results: For OE ufSSFP imaging, the maximum parenchymal signal is observed for flip angles around 23 under both normoxic and hyperoxic conditions. It is found that the sponge model accurately describes parenchymal signal at different breathing positions, thereby mitigating the confounding bias in the estimated oxygen enhancement from residual density modulations. From the model, an average lung oxygen enhancement of 7.0% 6 0.3% was found in the healthy volunteers, and the oxygenenhancement maps indicate a ventral to dorsal gravitation-related gradient. Conclusion:The study demonstrates the feasibility of wholelung OE-MRI from multi-volumetric ufSSFP in healthy volunteers.

show abstract

MRI of the lung (1/3): methods

Cited by 217 publications

References 31 publications

Targeting and in vivo imaging of non-small–cell lung cancer using nebulized multimodal contrast agents

Targeting and in vivo imaging of non-small–cell lung cancer using nebulized multimodal contrast agents

In silico modeling of oxygen-enhanced MRI of specific ventilation

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Contact Info

Product

Resources

About