MRI of transmembrane water efflux in gliomas

Ruan, Thomas; Keshari, Kayvan R.

doi:10.1038/s41551-022-00979-y

Cited by 3 publications

(8 citation statements)

References 13 publications

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“…Because the water permeability of AQP4 is much higher than other AQPs, it is the predominant transmembrane water transporter in the brain. 47,48 Therefore, it has been proposed that transmembrane water exchange rate can be a potential biomarker for the membrane expression of AQP4. 47 By optimizing the dynamic-contrast-enhanced MRI (DCE-MRI) to be more sensitive to transmembrane water exchange processes, the water efflux rate was revealed by the MRI signal changes, as water from the intracellular to extracellular space would alter the contrast enhancement.…”

Section: Dynamic-contrast-enhanced Mri Basedmentioning

confidence: 99%

“…47 By optimizing the dynamic-contrast-enhanced MRI (DCE-MRI) to be more sensitive to transmembrane water exchange processes, the water efflux rate was revealed by the MRI signal changes, as water from the intracellular to extracellular space would alter the contrast enhancement. 48 Based on the fast acquisition and shutter speed model, the intracellular-to-extracellular water-efflux-rate k io was measured. 47 By using AQP4 knockout and inhibition and correlating with AQP4 immunobiology, k io was found to be a sensitive and specific biomarker of AQP4 expression and function in gliomas.…”

Section: Dynamic-contrast-enhanced Mri Basedmentioning

confidence: 99%

“…However, whether it can be used in general conditions, especially under the condition with intact blood-brain barrier (BBB), remains to be investigated. 48 DIFFUSION AND ARTERIAL SPIN LABELING BASED TECHNIQUES. Diffusion MRI has emerged as a preferred technique for non-invasive detection of transmembrane water exchange.…”

Section: Dynamic-contrast-enhanced Mri Basedmentioning

confidence: 99%

“…Because the water permeability of AQP4 is much higher than other AQPs, it is the predominant transmembrane water transporter in the brain 47,48 . Therefore, it has been proposed that transmembrane water exchange rate can be a potential biomarker for the membrane expression of AQP4 47 .…”

Section: Glymphatic Imaging Techniquesmentioning

confidence: 99%

“…Therefore, it has been proposed that transmembrane water exchange rate can be a potential biomarker for the membrane expression of AQP4 47 . By optimizing the dynamic‐contrast‐enhanced MRI (DCE‐MRI) to be more sensitive to transmembrane water exchange processes, the water efflux rate was revealed by the MRI signal changes, as water from the intracellular to extracellular space would alter the contrast enhancement 48 . Based on the fast acquisition and shutter speed model, the intracellular‐to‐extracellular water‐efflux‐rate k io was measured 47 .…”

Section: Glymphatic Imaging Techniquesmentioning

confidence: 99%

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Glymphatic Imaging in Pediatrics

Li,

Lin,

Liu

et al. 2023

Magnetic Resonance Imaging

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The glymphatic system, which facilitates cerebrospinal fluid (CSF) flow through the brain parenchyma, is important for brain development and waste clearance. Advances in imaging techniques, particularly magnetic resonance imaging, have make it possible to evaluate glymphatic structures and functions in vivo. Recently, several studies have focused on the development and alterations of the glymphatic system in pediatric disorders. This review discusses the development of the glymphatic system, advances of imaging techniques and their applications in pediatric disorders. First, the results of the reviewed studies indicate that the development of the glymphatic system is a long‐lasting process that continues into adulthood. Second, there is a need for improved glymphatic imaging techniques that are non‐invasive and fast to improve suitability for pediatric applications, as some of existing methods use contrast injection and are susceptible to motion artifacts from long scanning times. Several novel techniques are potentially feasible for pediatric patients and may be used in the future. Third, the glymphatic dysfunction is associated with a large number of pediatric disorders, although only a few have recently been investigated. In conclusion, research on the pediatric glymphatic system remains an emerging field. The preliminary applications of glymphatic imaging techniques have provided unique insight into the pathological mechanism of pediatric diseases, but mainly limited in visualization of enlarged perivascular spaces and morphological measurements on CSF volumes. More in‐depth studies on glymphatic functions are required to improve our understanding of the mechanisms underlying brain development and pediatric diseases.Level of Evidence5Technical EfficacyStage 3

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Section: Dynamic-contrast-enhanced Mri Basedmentioning

confidence: 99%

Section: Dynamic-contrast-enhanced Mri Basedmentioning

confidence: 99%

Section: Dynamic-contrast-enhanced Mri Basedmentioning

confidence: 99%

Section: Glymphatic Imaging Techniquesmentioning

confidence: 99%

Section: Glymphatic Imaging Techniquesmentioning

confidence: 99%

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Glymphatic Imaging in Pediatrics

Li,

Lin,

Liu

et al. 2023

Magnetic Resonance Imaging

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Enhancing Surface Hydroxyl Group Modulation on Carbon Nitride Boosts the Effectiveness of Photodynamic Treatment for Brain Glioma

Qi,

Lu,

Gao

et al. 2024

ACS Appl. Mater. Interfaces

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The effectiveness of photodynamic therapy (PDT) in treating brain gliomas is limited by the solubility of photosensitizers and the production of reactive oxygen species (ROS), both of which are influenced by the concentration of photosensitizers and catalyst active sites. In this study, we developed a controllable surface hydroxyl concentration for the photosensitizer CN11 to address its poor water solubility issue and enhance PDT efficacy in tumor treatment. Compared to pure g-C3N4 (CN), CN11 exhibited 4.6 times higher hydrogen peroxide production under visible light, increased incidence of the n → π* electron transition, and provided more available reaction sites for cytotoxic ROS generation. These findings resulted in a 2.43-fold increase in photodynamic treatment efficacy against brain glioma cells. Furthermore, in vivo experiments conducted on mice demonstrated that CN11 could be excreted through normal cell metabolism with low cytotoxicity and high biosafety, effectively achieving complete eradication of tumor cells.

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The biophysics of water in cell biology: perspectives on a keystone for both marine sciences and cancer research

Pouliquen

2024

Front. Cell Dev. Biol.

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The biophysics of water, has been debated over more than a century. Although its importance is still underestimated, significant breakthroughs occurred in recent years. The influence of protein condensation on water availability control was documented, new findings on water-transport proteins emerged, and the way water molecules rearrange to minimize free energy at interfaces was deciphered, influencing membrane thermodynamics. The state of knowledge continued to progress in the field of deep-sea marine biology, highlighting unknown effects of high hydrostatic pressure and/or temperature on interactions between proteins and ligands in extreme environments, and membrane structure adaptations. The role of osmolytes in protein stability control under stress is also discussed here in relation to fish egg hydration/buoyancy. The complexity of water movements within the cell is updated, all these findings leading to a better view of their impact on many cellular processes. The way water flow and osmotic gradients generated by ion transport work together to produce the driving force behind cell migration is also relevant to both marine biology and cancer research. Additional common points concern water dynamic changes during the neoplastic transformation of cells and tissues, or embryo development. This could improve imaging techniques, early cancer diagnosis, and understanding of the molecular and physiological basis of buoyancy for many marine species.

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MRI of transmembrane water efflux in gliomas

Cited by 3 publications

References 13 publications

Glymphatic Imaging in Pediatrics

Glymphatic Imaging in Pediatrics

Enhancing Surface Hydroxyl Group Modulation on Carbon Nitride Boosts the Effectiveness of Photodynamic Treatment for Brain Glioma

The biophysics of water in cell biology: perspectives on a keystone for both marine sciences and cancer research

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