MRI patterns of global hypoxic-ischemic injury in adults

Muttikkal, Thomas Jose Eluvathingal; Wintermark, Max

doi:10.1016/j.neurad.2012.08.002

Cited by 46 publications

(43 citation statements)

References 14 publications

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“…Cardiac events or asphyxation may cause brain lesions in very hypoxia-sensitive areas such as the basal ganglia or the posterior brain areas. 17 Relation to acute mountain sickness. CBFV in the MCA increased in the non-AMS mountaineers earlier (at 3,440 m altitude) than in the AMS group (at 5,050 m altitude).…”

Section: Changes In Blood Pressure and Oxygenationmentioning

confidence: 99%

Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes

Feddersen¹,

Neupane

Thanbichler³

et al. 2015

J Cereb Blood Flow Metab

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Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophysiological changes by means of near infrared spectroscopy, electroencephalograpy (EEG), and transcranial doppler sonography at 100, 3,440 and 5,050 m above sea level in the Khumbu Himal, Nepal. Fourteen of the 26 mountaineers reaching 5,050 m altitude developed symptoms of AMS between 3,440 and 5,050 m altitude (Lake-Louise Score ⩾3). Their EEG frontal beta activity and occipital alpha activity increased between 100 and 3,440 m altitude, i.e., before symptoms appeared. Cerebral blood flow velocity (CBFV) in the anterior and middle cerebral arteries (MCAs) increased in all mountaineers between 100 and 3,440 m altitude. During further ascent to 5,050 altitude, mountaineers with AMS developed a further increase in CBFV in the MCA, whereas in all mountaineers CBFV decreased continuously with increasing altitude in the posterior cerebral arteries. These results indicate that hypobaric hypoxia causes different regional changes in CBFV despite similar electrophysiological changes.

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Section: Changes In Blood Pressure and Oxygenationmentioning

confidence: 99%

Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes

Feddersen¹,

Neupane

Thanbichler³

et al. 2015

J Cereb Blood Flow Metab

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show abstract

“…(10)(11)(12)(13)(14)(15)(16) The cases with bilateral frontal involvement may have hypoxia as underlying pathogenesis given the underlying respiratory distress and frontotemporal hypoperfusion as demonstrated by Helms et al, in COVID-19 patients admitted to ICU(5).…”

mentioning

confidence: 99%

Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection

Kandemirli¹,

Doğan²,

Sarıkaya³

et al. 2020

Radiology

267

285

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“…Cardiac arrest was the mechanism of injury in the majority of the patients of our study population (5 cases). Cardiac causes accounted for 16 out of 39 cases of hypoxic-ischemic insult in the study by Choi et al, 7 and 14 out of 22 cases in the study by Topcuoglu et al 8 .…”

Section: Discussionmentioning

confidence: 88%

Role of Magnetic Resonance Imaging in the Evaluation of Basal Ganglia Lesions

Kiran¹,

Baru²

2018

IJCMSR

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Radiologists will encounter bilaterally symmetrical abnormalities of the basal ganglia, usually in diffuse systemic and metabolic diseases. Study aimed to identify the spectrum of diseases involving basal ganglia disease and also to evaluate other sites of involvement in these patients. Material and methods: 30 patients referred to our hospitalwith suspicion of basal ganglia lesions subjected to MR examinations by 3TMR system using a 32-channel phased array head coil. Results: Most common etio-pathologies affecting basal ganglia are metabolic diseases (67%), Japanese encephalitis and dengue encephalitis (17%), Neoplasm's Glioma and DNET (10%) and degenerative NBIA and Huntington's disease (7%) respectively. Among metabolic diseases Hypoxic ischemic encephalopathy (30%) and Leigh's syndrome (30%) are the most common entities followed by hypoglycemic encephalopathy (10%) and posterior reversible encephalopathy syndrome (10%) diagnosed respectively. Among the Thirty patients with basal ganglia lesions, bilateral symmetrical involvement in 22 cases (73%), unilateral involvement in 5 cases (17%) and bilateral asymmetrical involvement in 3 cases (10%). There are 5 cases with Caudate +Putamen (Dorsal striatum), 4 cases with Putamen+globus pallidus (lentiform nucleus) and 7 cases withentire basal ganglia (Corpus striatum) involvement in metabolic disease patients. Conclusion: MR imaging has dramatically improved the ability to visualise deep grey structures of basal ganglia and spectrum.

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MRI patterns of global hypoxic-ischemic injury in adults

Cited by 46 publications

References 14 publications

Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes

Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes

Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection

Role of Magnetic Resonance Imaging in the Evaluation of Basal Ganglia Lesions

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