MRI Quantitative Study and Pathologic Analysis of Crush Injury in Rabbit Hind Limb Muscles

Zhang, Lianyang; Ding, Jun-tao; Wang, Yi; Zhang, Weiguo; Deng, Xiaojuan; Chen, Jinhua

doi:10.1016/j.jss.2010.09.014

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…There are no controlled models of open muscle trauma in the rabbit and only one closed study is reported. Zhang et al 231 used MRI to quantify muscle damage following closed crush injury in New Zealand white rabbits. Their description of injury mechanism is limited, however: ‘ Then, their right hind limbs were fixed with wooden splints and crushed with 25 kg heavy weight ’ 231.…”

Section: Small Animal Models Of Relevance To Military Extremity Injurymentioning

confidence: 99%

“…Zhang et al 231 used MRI to quantify muscle damage following closed crush injury in New Zealand white rabbits. Their description of injury mechanism is limited, however: ‘ Then, their right hind limbs were fixed with wooden splints and crushed with 25 kg heavy weight ’ 231. The only series describing experimental open muscle trauma in the rabbit are military studies from the Vietnam War period.…”

Section: Small Animal Models Of Relevance To Military Extremity Injurymentioning

confidence: 99%

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Modelling for conflict: the legacy of ballistic research and current extremity in vivo modelling

Eardley¹,

Watts

2013

J R Army Med Corps

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Extremity ballistic injury is unique and the literature intended to guide its management is commonly misinterpreted. In order to care for those injured in conflict and conduct appropriate research, clinicians must be able to identify key in vivo studies, understand their weaknesses and desist the propagation of miscited and misunderstood ballistic dogma. This review provides the only inclusive critical overview of key studies of relevance to military extremity injury. In addition, the non-ballistic studies of limb injury, stabilisation and contamination that will form the basis from which future small animal extremity studies are constructed are presented. With an awareness of the legacy of military wound models and an insight into available generic models of extremity injury and contamination, research teams are well placed to optimise future military extremity injury management.

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Section: Small Animal Models Of Relevance To Military Extremity Injurymentioning

confidence: 99%

Section: Small Animal Models Of Relevance To Military Extremity Injurymentioning

confidence: 99%

Modelling for conflict: the legacy of ballistic research and current extremity in vivo modelling

Eardley¹,

Watts

2013

J R Army Med Corps

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“…This is important for exploration of the induced mechanism of vasodilatory edema. Moreover, the findings of this study suggested that MRI is an accurate, sensitive and convenient measurement tool [19] that can be used to quantitatively evaluate preclinical antihypertensive effects and adverse effects, and these factors are of great value in translational medicine.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of ultra-early and dose-dependent edema and ultrastructural changes in the myocyte during anti-hypertensive drug delivery in the spontaneously hypertensive rat model

et al. 2020

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“…Because of the sensitivity of MR-T2 mapping to acute changes in the activity states of muscle, the method shows great potential for identifying muscle activation patterns in a variety of normal and pathological conditions (34). Previous studies used the method to measure the extent of inflammatory edema induced in muscle by eccentric exercise (32,35), crush injury of rabbit hindlimb muscles (36), damage in human leg muscles induced by downhill running (37) and in mice muscles (38).…”

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confidence: 99%

MRI Quantitative Analysis of Eccentric Exercise-induced Skeletal Muscle Injury in Rats

Xia

Meng

et al. 2020

Academic Radiology

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Background: The aim of this study was to investigate the value of magnetic resonance (MR) quantitative analysis (MR-T2 mapping technique) for the evaluation of eccentric exercise-induced skeletal muscle injury. Materials and Methods: We established an animal model of eccentric exercise-induced damage of Sprague Dawley rat skeletal muscle and evaluated the animals by MR imaging, determined the serum levels of fast skeletal troponin (fsTnI), and examined muscle histopathology, at 0, 1, 2, 4, and 7 days after eccentric exercise. The associations between MR imaging findings, and histopathological and laboratory results were evaluated. Results: T2-weighted images (WIs) of quadriceps femoris muscles showed obvious high signal intensities after exercise, and the T2 values and serum fsTnI levels continued to increase, peaking at day 2 after exercise, p< 0.05. The histopathological findings in muscle specimens, which included swollen and ruptured cells, enlarged extracellular spaces, inflammation, and regeneration of muscle fibers, showed similar trends. After day 2, muscle specimens began to show evidence of self-repair, the T2WI signals decreased in intensity, and the T2 values and serum fsTnI levels decreased; however, at day 7 post injury, the values remained slightly higher than those in the control animals, p< 0.05. The T2 value was significantly correlated with the serum fsTnI level (r = 0.896, p< 0.01). Conclusion: T2 mapping technology accurately reflects the histopathological and fsTnI abnormalities and the degree of skeletal muscle damage associated with eccentric exercise followed by recovery. Because T2 mapping technology is noninvasive and can be quantitatively analyzed, it might become the preferred method for performing the diagnosis of eccentric exercise-induced skeletal muscle injury.

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MRI Quantitative Study and Pathologic Analysis of Crush Injury in Rabbit Hind Limb Muscles

Cited by 9 publications

References 10 publications

Modelling for conflict: the legacy of ballistic research and current extremity in vivo modelling

Modelling for conflict: the legacy of ballistic research and current extremity in vivo modelling

Evaluation of ultra-early and dose-dependent edema and ultrastructural changes in the myocyte during anti-hypertensive drug delivery in the spontaneously hypertensive rat model

MRI Quantitative Analysis of Eccentric Exercise-induced Skeletal Muscle Injury in Rats

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