MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles

Sánchez, Pablo Tercedor; Valero, Elsa; Gálvez, Natividad; Domínguez‐Vera, José M.; Marinone, Massimo; Poletti, G.; Corti, M.; Lascialfari, A.

doi:10.1039/b809645g

Cited by 53 publications

(39 citation statements)

References 31 publications

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“…In addition to Fe, other metallic species, such as Cu [21], Co [22], and Gd [23] are also amenable to encapsulation by ferritins. Taking advantage of this property, several groups have reported synthesis of nanoparticles using ferritins as nanoreactors.…”

Section: Architecture and Surface Properties Of Ferritinsmentioning

confidence: 99%

Ferritins as nanoplatforms for imaging and drug delivery

Zhen

Tang

Todd

et al. 2014

Expert Opinion on Drug Delivery

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Introduction Due to unique architecture and surface properties, ferritin has emerged as an important class of biomaterial. Many studies suggest that ferritin and its derivatives hold great potential in a wide range of bio-applications. Areas covered In this review, we summarize recent progress on employing ferritins as a platform to construct functional nanoparticles for applications in magnetic resonance imaging (MRI), optical imaging, cell tracking, and drug delivery. Expert opinion As a natural polymer, ferritins afford advantages such as high biocompatibility, good biodegradability, and a relatively long plasma half-life. These attributes put ferritins ahead of conventional materials in clinical translation for imaging and drug delivery purposes.

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Section: Architecture and Surface Properties Of Ferritinsmentioning

confidence: 99%

Ferritins as nanoplatforms for imaging and drug delivery

Zhen

Tang

Todd

et al. 2014

Expert Opinion on Drug Delivery

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“…Beside other metal complexes, magnetic nanoparticles attract special attention due to significantly higher relaxivity than those of available gadolinium-based complexes. [3][4][5] Several nanocarriers, such as liposomes and microbubbles, have been investigated to determine their ability to deliver higher amounts of contrast agent. [6][7][8] For in vivo application, these carrier molecules and their metabolic products should be biocompatible and stable within physiological system.…”

Section: Introductionmentioning

confidence: 99%

Iron-based ferritin nanocore as a contrast agent

Sana

Johnson

Sheah³

et al. 2010

Biointerphases

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Self-assembling protein cages have been exploited as templates for nanoparticle synthesis. The ferritin molecule, a protein cage present in most living systems, stores excess soluble ferrous iron in the form of an insoluble ferric complex within its cavity. Magnetic nanocores formed by loading excess iron within an engineered ferritin from Archaeoglobus fulgidus (AfFtn-AA) were studied as a potential magnetic resonance (MR) imaging contrast agent. The self-assembly characteristics of the AfFtn-AA were investigated using dynamic light scattering technique and size exclusion chromatography. Homogeneous size distribution of the assembled nanoparticles was observed using transmission electron microscopy. The magnetic properties of iron-loaded AfFtn-AA were studied using vibrating sample magnetometry. Images obtained from a 3.0 T whole-body MRI scanner showed significant brightening of T1 images and signal loss of T2 images with increased concentrations of iron-loaded AfFtn-AA. The analysis of the MR image intensities showed extremely high R2 values (5300 mM−1 s−1) for the iron-loaded AfFtn-AA confirming its potential as a T2 contrast agent.

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“…Alternatively, the Gd 2 O 3 core has been incorporated in polysiloxane shells allowing also derivatization on the surface for the design of targeted or multimodal probes [180,181]. Apoferritin was also described by sanchez et al as a potential sequestering agent for Gd 2 O 3 with relaxivities 10 to 25 folds higher than Gd 3+ -dTpA, depending on the field strength [182].…”

Section: Gadolinium Oxide Nanoparticlesmentioning

confidence: 99%