MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy

Liu, Sitong; Zhang, Chen; Zhou, Yuanyuan; Zhang, Fang; Duan, Xiaohui; Liu, Yang; Zhao, Xibang; Liu, Jie; Shuai, Xintao; Wang, Jiali; Cao, Zhong

doi:10.1016/j.biomaterials.2023.122030

Cited by 35 publications

(19 citation statements)

References 73 publications

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“…Their high sensitivity and specificity enable the detection of biomarkers associated with inflammation at incredibly low concentrations 78 . Additionally, nanotechnologies not only improve imaging accuracy and sensitivity but offer real-time monitoring for assessing inflammation levels in the body 79 . Herein, we discuss nanobiosensors and imaging nanoprobes in diagnosing inflammation by comparing their advantages, disadvantages and clinical application prospects.…”

Section: Nanotechnology-assisted Inflammation Diagnosismentioning

confidence: 99%

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Liu,

Lin,

Wang

et al. 2024

Theranostics

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Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases. Accurate detection and timely therapeutic intervention on inflammatory dysregulation are crucial for the effective therapy of inflammation-associated diseases. However, the clinical outcomes of inflammation-involved disorders are still unsatisfactory. Therefore, there is an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations with traditional therapeutics. Biomedical nanotechnology is one of the promising fields that can potentially transform the diagnosis and treatment of inflammation. In this review, we outline recent advances in biomedical nanotechnology for the diagnosis and treatment of inflammation, with special attention paid to nanosensors and nanoprobes for precise diagnosis of inflammation-related diseases, emerging anti-inflammatory nanotherapeutics, as well as nanotheranostics and combined anti-inflammatory applications. Moreover, the prospects and challenges for clinical translation of nanoprobes and anti-inflammatory nanomedicines are highlighted.

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Section: Nanotechnology-assisted Inflammation Diagnosismentioning

confidence: 99%

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Liu,

Lin,

Wang

et al. 2024

Theranostics

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“…Ouyang et al [79] synthesized Gd 2 (CO 3 ) 3 @PDA nanoparticles with a core-shell structure by depositing a PDA layer on the surface of Gd 2 (CO 3 ) 3 nanoparticles; the results showed that the PDA layer reduced the toxicity to mouse chondrocytes. Liu et al [80] developed arginine (Arg)and Mn 2+ -doped mesoporous polydopamine (MPDA) nanoparticles (DAMM NPs) to deliver dexamethasone (DEX) for OA treatment. Among them, DAMM nanoparticles chelated with Mn 2+ have a strong T1-T2 magnetic resonance contrast ability, which enables the real-time visualization of damaged articular cartilage (figure 10(A)).…”

Section: Imagingmentioning

confidence: 99%

Recent advances of mussel-inspired materials in osteoarthritis therapy

Xiao,

Yan,

Ding

et al. 2023

Mater. Res. Express

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Osteoarthritis (OA) is a common chronic joint disease that significantly affects the quality of life and can lead to disability. Oral and intra-articular administration are the main clinical treatments used to alleviate inflammation and pain. However, the therapeutic efficiency of these approaches is limited by burst drug release, poor retention time, and undesirable toxic effects. In recent years, mussel-inspired materials with strong interfacial adhesiveness have been considered as promising candidates for the treatment of OA. These materials can act as delivery platforms to enhance drug availability; moreover, they display multiple non-pharmacological pathways that alleviate OA. In this review, we introduce the pathological features of OA, summarize the fabrication methods for mussel-inspired materials, and highlight their superiority in response to recent therapeutic strategies for OA.

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“…Osteoarthritis (OA) is a typical complex and multifactorial joint disease that requires combination therapy as it involves a cascade of pathological processes, beginning with damage to the articular cartilage and leading to a disruption of lubrication. − Clinically, over 60% of individuals with OA are in the advanced stage, where chronic joint inflammation, dysfunction in lubrication, and degradation of cartilage tissue are recognized as the three crucial aspects that worsen the condition. , The increasing evidence suggests that a combination of multiple drugs may present a promising strategy for more effective treatment of OA. − However, existing treatments primarily concentrate on only partial OA key factors, effectively alleviating the symptoms but failing to recover advanced OA . Addressing the three crucial factors simultaneously and achieving sustained effectiveness are essential to halting the progression of advanced OA, but the rational design of these systems is highly complicated and challenging.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

Chen,

Li,

Zhu

et al. 2024

ACS Nano

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The complexity, heterogeneity, and drug resistance of diseases necessitate a shift in therapeutic paradigms from monotherapy to combination therapy, which could augment treatment efficiency. Effective treatment of advanced osteoarthritis (OA) requires addressing three key factors contributing to its deterioration: chronic joint inflammation, lubrication dysfunction, and cartilagetissue degradation. Herein, we present a supramolecular nanomedicine of multifunctionality via molecular recognition and selfassembly. The employed macrocyclic carrier, zwitterion-modified cavitand (CV-2), not only accurately loads various drugs but also functions as a therapeutic agent with lubricating properties for the treatment of OA. Kartogenin (KGN), a drug for articular cartilage regeneration and protection, and flurbiprofen (FP), an antiinflammatory agent, were coloaded onto CV-2 assembly, forming a supramolecular nanomedicine KGN&FP@CV-2. The three-in-one combination therapy of KGN&FP@CV-2 addresses the three pathological features for treating OA collectively, and thus provides long-term therapeutic benefits for OA through sustained drug release and intrinsic lubrication in vivo. The multifunctional integration of macrocyclic delivery and therapeutics provides a simple, flexible, and universal platform for the synergistic treatment of diseases involving multiple drugs.

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MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy

Cited by 35 publications

References 73 publications

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Recent advances of mussel-inspired materials in osteoarthritis therapy

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

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