mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients

Li, Yu Mei; Chen, Zhi Qiang; Yao, Xu; Yang, Ai Zhen; Li, An Sheng; Liu, Dong Ming; Gong, Jian

doi:10.1016/s1001-9294(10)60042-9

Cited by 12 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can be explained by the role of chemokines in the inflammatory process and tissue damage through lymphocyte trafficking 26 , in particular IP-10 chemokine via its interaction with its receptor CXCR3 27 . This agrees with several studies that stated that there was an inverse statistically significant correlation between circulating CD4+CXCR3+ and renal SLEDAI done in patients with pSLE 17,5,3,23 .…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

CXCR 3 expression on CD4+T cells and in renal tissue of pediatric systemic lupus erythematosus patients

Ibrahim

El-Sayed

Said

et al. 2019

Egypt J Pediatr Allergy Immunol

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

“…Similarly, CXCR3 was found to accumulate at sites of inflammation; skin in discoid lupus 19 , Sarcodosis 20 , Sjogren Syndrome and dermatomyositis 21 . Opposite results were seen in some studies 22,23 .…”

Section: Discussionmentioning

confidence: 46%

CXCR 3 expression on CD4+T cells and in renal tissue of pediatric systemic lupus erythematosus patients

Ibrahim

El-Sayed

Said

et al. 2019

Egypt J Pediatr Allergy Immunol

View full text Add to dashboard Cite

“…It is known that the TregCCR5 +/+ cells express higher levels of the anti-inflammatory cytokine IL-10 compared to TregCCR5 -/- (26). The protective effect of this mutation on SLE patients has been attributed to increased expression of CCR5 in Th1 cells in active SLE patients compared to SLE patients with clinical remission and healthy individuals (27,28).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of CCR5Δ32 Polymorphism in Patients with Systemic Lupus Erythematosus and Healthy Individuals

et al. 2018

View full text Add to dashboard Cite

Background and Objectives: CC chemokine receptor type 5 (CCR5) is a chemokine receptor expressed at high levels on the surface of T-cells. A 32-bp deletion in the coding region of the CCR5 (CCR5Δ32) leads to production of an incomplete protein that is not expressed on the cell surface. CCR5Δ32 may be involved in development of autoimmune disease, such as systemic lupus erythematosus. We investigated frequency of the CCR5Δ32 polymorphism in SLE patients and healthy controls, and evaluated the relationship between the CCR5Δ32 polymorphism and susceptibility to SLE in Golestan Province, Iran. Methods: Whole blood samples were taken from 80 SLE patients admitted to Shahid Sayyad Shirazi hospital and 80 healthy controls (from a blood bank) in the Golestan Province, in 2016. Baseline clinical and laboratorial characteristics were evaluated regarding the CCR5Δ32 genotypes. The CCR5Δ32 polymorphism was determined from genomic DNA by polymerase chain reaction. Result: Genotype frequencies of both groups were in the Hardy-Weinberg equilibrium. The frequencies of the CCR5 and the CCR5Δ32 alleles were 98.13% and 1.88% among the patients, and 98.75% and 1.25% among the controls, respectively. Homozygote CCR5Δ32 was not observed in the subjects. The frequency of heterozygous Δ32 was 3.8% and 2.5% among the SLE patients and controls, respectively (P-value>0.05). There was no significant association between the CCR5 status and clinical signs of SLE (P>0.05). Conclusion: Our data suggest that the CCR5Δ32 polymorphism has no correlation with SLE in our study population. In addition, the frequency of the Δ32 polymorphism in SLE patients and controls does not follow the Hardy-Weinberg equilibrium

show abstract

“…A possible explanation for this result is that CCR5, and its ligands represent a real contribution to SLE pathogenesis. Preceding authors have described higher levels of CCR5 mRNA in patients with SLE (Li et al ., ). Others have documented that CCR5‐positive cells or increased serum levels of its ligands could be very important in the initiation and perpetuation of tissue inflammation and so in disease activity.…”

Section: Discussionmentioning

confidence: 97%

CCR5‐Delta32: implications in SLE development

Carvalho

Calvisi²,

Leal

et al. 2013

Int J Immunogenetics

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active SLE. C-C chemokine receptor type 5 (CCR5) is involved in the recruitment of inflammatory cells into tissues, and mechanisms modulating CCR5 expression and function may interfere in SLE development, influencing the clinical course of the disease. The aim of this study was to evaluate the possible association between the CCR5∆32 base-pair deletion polymorphism and SLE disease in a group of Portuguese patients. A total of 219 patients with SLE and 205 healthy individuals were studied. The frequency of CCR5/∆32 heterozygotes was lower in patients with SLE than in controls (8% vs. 15% OR = 0.5162; P = 0.0319), suggesting a protective association between CCR5∆32 allele and SLE. These results highlight the protective role of Th1 cells that express CCR5 in SLE pathogenesis.

show abstract

mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients

Abstract: Increased expressions of CCR5 and CX3CR1 on PBMCs may be indicators in clinical survey for SLE.

Cited by 12 publications

References 21 publications

CXCR 3 expression on CD4+T cells and in renal tissue of pediatric systemic lupus erythematosus patients

CXCR 3 expression on CD4+T cells and in renal tissue of pediatric systemic lupus erythematosus patients

Evaluation of CCR5Δ32 Polymorphism in Patients with Systemic Lupus Erythematosus and Healthy Individuals

CCR5‐Delta32: implications in SLE development

Contact Info

Product

Resources

About