“…Some methods, algorithms, and functional tools were constructed to facilitate the application or improve the performance of the classic virtual screening strategy. − Machine learning methods were also adopted in this collection to identify new hit compounds, discover promising leads for cholestasis, interpret QSAR models, and learn molecular representations. − DiStefano et al and Mao et al conducted research on toxicity prediction and antiviral drug design, respectively. Moreover, ML was also applied to explore the pharmaceutical properties of diverse drug candidates. − A novel knowledge base for nonalcoholic fatty liver disease was developed . Heyndrickx et al adopted cross-pharma federated learning to unleash the benefit of QSAR.…”