MRSA, EBSL, and Biofilm Formation in Diabetic Foot Ulcer Infections

Husain, Fohad Mabood; Khan, Mohammad Saeed; Zubair, Mohammad; Khan, Altaf; Noor, Saba; Hassan, Iftekhar; Arshad, Muhammad; Khan, Mohd Shahnawaz; Qais, Faizan Abul; Alamery, Salman

doi:10.1007/978-981-15-7639-3_9

Cited by 1 publication

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have shown that silver and zinc oxide nanoparticles can interfere with quorum sensing mechanisms in pathogenic bacteria. By disrupting quorum sensing, these nanoparticles can influence the expression of genes responsible for regulating swarming behavior (AL-Dulaimy et al, 2023;Saeki et al, 2022;Khan et al, 2020). Corresponding Author: Lina Abd Al-Kadhim Auda Among the extensive array of virulence factors employed by P. mirabilis to induce Catheter Associated Urinary Tract Infections (CAUTIs), certain factors associated with biofilm formation, such as swarming motility, have been identified.…”

Section: Gene Expression Of Rsma Gene Of P Mirabilismentioning

confidence: 99%

The Effect of Zinc Oxide and Silver Nanoparticles on rsmA and rsbA Expression in Proteus Mirabilis

Al-Kadhim Aud,

Kadhim,

Yaaqoob

2023

IJPBMS

View full text Add to dashboard Cite

This study investigated the effect of zinc oxide nanoparticles (ZnO-NPs) and silver nanoparticles (AgNPs) on the expression of the rsmA and rsbA genes in multi-drug resistant Proteus mirabilis. The nanoparticles were synthesized using the cell-free supernatant of P. mirabilis. Gene expression levels were quantified using quantitative Reverse Transcription Real-Time PCR (qRT-PCR) technique. The results showed that the expression of the rsmA gene was significantly downregulated in P. mirabilis isolates treated with ZnO-NPs, AgNPs, and Ag-ZnO-NPs compared to the control untreated isolate. The fold change values for gene expression were 18.32, 7.73, and 1.64 for ZnO-NPs, AgNPs, and Ag-ZnO-NPs, respectively. Similar downregulation of the rsmA gene has been observed in other bacterial species treated with silver and zinc oxide nanoparticles. Additionally, the expression of the rsbA gene was significantly downregulated in P. mirabilis treated with ZnO-NPs and AgNPs, while Ag-ZnO-NPs did not show a significant effect on rsbA gene expression. These findings suggest that ZnO-NPs and AgNPs have potential as antimicrobial agents by regulating gene expression in P. mirabilis.

show abstract

Section: Gene Expression Of Rsma Gene Of P Mirabilismentioning

confidence: 99%