Run-time mixed-grained reconfigurable architectures emerged as an efficient solution to deal with the heterogeneous and at-design-time unpredictable nature of advanced applications. Due to interconnection limitations, the reconfigurable elements are grouped into tiles communicating through an on-chip network. State-of-the-art run-time accelerator binding schemes, i.e., mapping the accelerators to elements in the physical reconfigurable array, do not deal with such tile-based architectures. We propose a new scheme for runtime accelerator binding into our tile-based mixed-grained reconfigurable architecture. By means of an advanced video encoding application, we illustrate that our scheme reduces the inter-tile communication overhead by up to 44% (avg. 23%).