MSX <sub>1</sub> gene variant and non-syndromic clefting: Association or rejection?

Reddy, Naveen Admala; Adusumilli, Gopinath; Reddy, Jayaprakash; Devanna, Raghu; Saravanan, P.; Rohra, Mayur G

doi:10.4103/0970-9290.131054

Indian J Dent Res

2014

DOI: 10.4103/0970-9290.131054

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MSX ₁ gene variant and non-syndromic clefting: Association or rejection?

Naveen Admala Reddy

Gopinath Adusumilli

Jayaprakash Reddy

et al.

Abstract: From a genetically diverse etiology MSX 1 799 G >T gene variant may be a good screening marker for NSCL/P in Raichur patients.

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2023

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MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala

Jyothish,

George,

Narayanan

et al. 2023

The Cleft Palate Craniofacial Journal

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Objective The purpose of this study was to investigate the contribution of MSX1 gene polymorphisms to the risk of developing NSCLP. Design Case-Control Study. Setting A tertiary care centre. Patients/Participants The sample consisted of 200 subjects (100 cases and 100 controls). Interventions None. Main Outcome Measure(s) Genotyping was performed by restriction fragment length polymorphism. Allele and genotype frequencies were calculated between patients and controls and analyzed using online Web Tools such as SISA and SNPstats. The MSX1 gene polymorphisms c. 799 GT, c.458 CA can be risk factors in the development of orofacial clefts. Results In the cases, an association was found between NSCLP and c.799 and c.458 of the MSX1 gene when compared with the control. The dominant and overdominant models, c. 799 GT, c.458 CA genotypes and c. 799 T, c.458 A alleles in the population are said to be the main risk factors to develop the NSCLP in our study population. The genotype variation of c 799 G/T and c.458 C/A are revealed to be specifically contributing to an NSCLP-type Cleft lip and Palate. It is worth noting that NSCLP females in the study population showed a stronger association with heterozygous genotypes of c.799 and c.458. However, further investigation with a larger cohort is necessary to confirm these findings. Conclusion Overall the results of the study revealed that MSX1 c 799 G > T and c.458 C > A can be considered as one of the genetic risk factors in the formation of Non-Syndromic Cleft Lip and Palate in the study population.

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MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala

Jyothish,

George,

Narayanan

et al. 2023

The Cleft Palate Craniofacial Journal

View full text Add to dashboard Cite

show abstract

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MSX ₁ gene variant and non-syndromic clefting: Association or rejection?

Abstract: From a genetically diverse etiology MSX 1 799 G >T gene variant may be a good screening marker for NSCL/P in Raichur patients.

Cited by 1 publication

References 1 publication

MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala

MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala

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MSX 1 gene variant and non-syndromic clefting: Association or rejection?

Abstract: From a genetically diverse etiology MSX 1 799 G >T gene variant may be a good screening marker for NSCL/P in Raichur patients.

Cited by 1 publication

References 1 publication

MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala

MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala

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Product

Resources

About

MSX ₁ gene variant and non-syndromic clefting: Association or rejection?