Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!

Reddy, Naveen Admala; Adusumilli, Gopinath; Devanna, Raghu; Mayur, Rohra G; Saravanan, P.; Arujnan, Sharmila

doi:10.4103/0971-6866.124376

Cited by 3 publications

(2 citation statements)

References 9 publications

(10 reference statements)

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“…This suggests that since the interval was not short, there may be a more prevalent tendency for hypodontia prevalence in females. We may agree with the results of some surveys, although other studies have documented females prominence over males (31).…”

Section: Prevalence By Type Of Teethsupporting

confidence: 93%

A Scoping Review: Gene Mutations of Nonsyndromic Hypodontia and Its Prevalence in Gender and Type of Teeth

Wan Saimi,

Hadi Ahmad,

Ismail

et al. 2023

JUMMEC

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Non-syndromic hypodontia is a developmental anomaly characterized by the absence of one to six of permanent teeth. The goal of this review was to identify all known gene mutations, prevalence of gender and type of teeth, to review current research and identify knowledge gaps on the topic of nonsyndromic hypodontia. Three electronic databases were performed (Science Direct, PubMed, and Scopus) and restricted to English papers published after 2012 until 2019. Search terms were combined as follows: Hypodontia or 'non-syndromic hypodontia' and 'genes' or 'tooth anomaly' and 'mutation' or 'genes' and were checked against the inclusion criteria independently by two investigators. From 16 studies, five genes currently known caused non-syndromic hypodontia: WNT10A (37 variants, 256 patients), MSX1 (9 variants, 112 patients), PAX9 (17 variants, 79 patients), AXIN2 (8 variants, 60 patients) and EDA (2 variants, 11 patients). It was demonstrated that females exhibited a higher prevalence of hypodontia with 89.3% as compared to males with 84.2%. The most commonly missing teeth was a lateral incisor, followed by second premolar and central incisor. Five genes, including WNT10A, PAX9, MSX1, AXIN2 and EDA, are currently considered to have the ability to cause nonsyndromic hypodontia. Lateral incisor was found to be commonly missing teeth and there was an increased risk for females to have hypodontia than males.

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Section: Prevalence By Type Of Teethsupporting

confidence: 93%

A Scoping Review: Gene Mutations of Nonsyndromic Hypodontia and Its Prevalence in Gender and Type of Teeth

Wan Saimi,

Hadi Ahmad,

Ismail

et al. 2023

JUMMEC

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“…It was observed that, in addition to developing the agenesis of certain dental groups, mutations of this gene were also related to the occurrence of cleft lip and/or palate (Gene, 2010). Research, Society and Development, v. 9, n. 11, e2449119882, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i11.9882 8 Current mutations reported in the MSX1 Reddy, et at., (2013) aimed to evaluate whether the msx1 671 T> C gene variant was involved in the etiology of non-syndromic dental agenesis in Raichur patients. Blood samples were collected from 50 affected individuals (test group) and 50 patients without agenesis (control group).…”

Section: Msx1mentioning

confidence: 99%

Genetic bases related to the development of non-syndromic dental agenesis: a literature review

Silva

Luiz

Bachesk

et al. 2020

RSD

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Non-syndromic dental agenesis is characterized as the most common developmental anomaly in humans, causing the lack of one or more teeth, in deciduous or permanent dentition. Mutations in specific genes of dental development are pointed as etiological factors of this anomaly. To perform this work, two electronic databases were consulted to conduct a literature survey, including PubMed and BVS. The descriptor "Anodontia" was used in both. The articles were filtered from 2010 to 2020, including full texts, in english, portuguese and spanish. Dissertations, theses and book chapters were discarded. In PubMed, from 508 articles found, 13 were included for review. In the BVS, from 304 articles found, 07 were included for review, totaling 20 articles. Studies have shown that mutations by nucleotide subitusing and deletion were more present in genes that cause dental agenesis (PAX9, MSX1, AXIN2, WNT). In epidemiologic studies, women showed greater involvement than men, both in deciduous and permanent dentition, in a ratio of 3:2. In addition, leukoderms showed greater involvement than melanoderms. Knowledge of the genotype-phenotype correlation between mutations and dental agenesis is important for the dental surgeon, as it assists in diagnosis, genetic counseling, treatment and prognosis.

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Single Nucleotide Polymorphism (SNPs) in the Genes Associated with Tooth Agenesis

Shahid¹,

Joshi²,

Alqhtani³

et al. 2018

Eur J Exp Bio

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Objectives: The main focus of this review article was to collate up to date knowledge with regard to significance of single nucleotide polymorphisms (SNPs) in various genes associated with tooth agenesis. Failure to develop complete set of teeth also called tooth agenesis is a common developmental abnormality manifested mainly as an isolated condition. This anomaly is also associated with many developmental syndromes. Methods:We reviewed the evidence from the literature with regard to SNPs in many genes associated with this developmental anomaly. The information contained in this review deals only with non-syndromic form of tooth agenesis. This condition generally affects third molars or one or few other permanent teeth, however, in some cases its severity is relatively prevalent. Results and Conclusions:Mutations in genes such as Msh homeobox 1 (MSX1), Paired box gene 9 (PAX9), Axis inhibitor protein 2 (AXIN2) and Ectodysplasin A (EDA) have been identified that are associated with the familial form of the disease. It has been shown that the phenotypes associated with these mutations indicate the involvement of more complex mechanisms.Clinical Significance: Evidence collected so far has immense clinical significance to clinical dentists in providing comprehensive guide outlining the role of these gene mutations (SNPs) in various genes and also how the patients affected with this condition will be clinically diagnosed and managed in future.

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Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!

Cited by 3 publications

References 9 publications

A Scoping Review: Gene Mutations of Nonsyndromic Hypodontia and Its Prevalence in Gender and Type of Teeth

A Scoping Review: Gene Mutations of Nonsyndromic Hypodontia and Its Prevalence in Gender and Type of Teeth

Genetic bases related to the development of non-syndromic dental agenesis: a literature review

Single Nucleotide Polymorphism (SNPs) in the Genes Associated with Tooth Agenesis

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