MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

Wong, Hoi Leong Xavier; Jin, Guoxiang; Cao, Renhai; Zhang, Shuo; Cao, Yihai; Zhou, Zhongjun

doi:10.1038/ncomms10824

Cited by 65 publications

(66 citation statements)

References 60 publications

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“…One example is via suppression of vascular endothelial growth factor C (VEGF-C) expression, mediated in part by membrane type 1-matrix metalloproteinase signaling that suppresses macrophage production of VEGF-C 41 . Likewise, the matricellular protein thrombospondin 1 (TSP1) also suppresses macrophage expression of VEGF-C, as described by Masli and colleagues 42 .…”

Section: Eye Immune Privilege Breach and The Mpsmentioning

confidence: 99%

New insights into mononuclear phagocyte biology from the visual system

2017

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Major advances in mononuclear phagocyte biology have been realized, yet key questions pertinent to health and disease remain, including in the visual system. One problem concerns how dendritic cells can trigger immune responses from certain tightly regulated immune privileged sites of the eye. Another, albeit separate, problem involves whether functional specializations exist for microglia versus monocytes in neurodegenerating retinas. We examine novel insights in eye immune privilege and, separately, review recent inroads concerning retinal degeneration. Both themes have been extensively studied in the visual system, and exhibit parallels highlighted here with recent findings in CNS mononuclear phagocytes and in the periphery.

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Section: Eye Immune Privilege Breach and The Mpsmentioning

confidence: 99%

New insights into mononuclear phagocyte biology from the visual system

2017

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“…The processing converts EphA2 into a ligand‐independent signal transducer that shows opposite activity of the ligand‐bound receptor by promoting cell motility . MT1‐MMP also sheds CD44 and its homolog lymphatic vessel endothelial hyaluronan receptor 1 and enhances cell motility and lymphangiogenesis, respectively . Likewise, biological feedback due to MT1‐MMP expression in producer cells reflects the altered functions of the processed substrate proteins.…”

mentioning

confidence: 99%

“…(5,6) MT1-MMP also sheds CD44 and its homolog lymphatic vessel endothelial hyaluronan receptor 1 and enhances cell motility (7) and lymphangiogenesis, respectively. (8) Likewise, biological feedback due to MT1-MMP expression in producer cells reflects the altered functions of the processed substrate proteins. Therefore, the diverse functions of MT1-MMP in tissues reflect the available substrates in the cellular microenvironment.…”

mentioning

confidence: 99%

Integrated functions of membrane‐type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase

Sakamoto

Seiki

2017

Cancer Science

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Membrane‐type 1 matrix metalloproteinase (MT1‐MMP) is expressed in different types of invasive and proliferative cells, including cancer cells and stromal cells. MT1‐MMP cleaves extracellular matrix proteins, membrane proteins and other pericellular proteins, thereby changing the cellular microenvironment and regulating signal activation. Critical roles of protease activity in cancer cell proliferation, invasion and metastasis have been demonstrated by many groups. MT1‐MMP also has a non‐protease activity in that it inhibits the oxygen‐dependent suppression of hypoxia‐inducible factors (HIFs) via Munc18‐1‐interacting protein 3 (Mint3) and thereby enhances the expression of HIF target genes. Elevated HIF activity in MT1‐MMP‐expressing cancer cells is a fundamental mechanism underlying the Warburg effect, a well‐known phenomenon where malignant cancer cells exhibit a higher rate of glucose metabolism. Because specific intervention of HIF activation by MT1‐MMP suppresses tumor formation by cancer cells in mice, both the proteolytic and non‐proteolytic activities of MT1‐MMP are important for tumor malignancy and function in an integrated manner. In this review, we summarize recent findings relating to how MT1‐MMP activates HIF and its effects on cancer cells and stromal cells.

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“…In a recent study, analysis in mice mutants for MMP14 (Matrix Metalloproteinase 14), also known as MT1‐MMP, revealed a vast increase in corneal and diaphragmatic lymphangiogenesis marked by LYVE1 staining . Increased lymphangiogenesis was accompanied by upregulation of Vefgc and Vegfd but not Vegfa , supporting a lymphatic rather than angiogenic effect.…”

Section: Lymphatics In Health and Diseasementioning

confidence: 99%

Building the drains: the lymphatic vasculature in health and disease

Galanternik

Stratman

Jung

et al. 2016

WIREs Developmental Biology

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The lymphatic vasculature is comprised of a network of endothelial vessels found in close proximity to but separated from the blood vasculature. An essential tissue component of all vertebrates, lymphatics are responsible for the maintenance of fluid homeostasis, dissemination of immune cells, and lipid reabsorption under healthy conditions. When lymphatic vessels are impaired due to invasive surgery, genetic disorders, or parasitic infections, severe fluid build-up accumulates in the affected tissues causing a condition known as lymphedema. Malignant tumors can also directly activate lymphangiogenesis and use these vessels to promote the spread of metastatic cells. Although their first description goes back to the times of Hippocrates, with subsequent anatomical characterization at the beginning of the 20th-century, the lack of identifying molecular markers and tools to visualize these translucent vessels meant that investigation of lymphatic vessels fell well behind research of blood vessels. However, after years under the shadow of the blood vasculature, recent advances in imaging technologies and new genetic and molecular tools have accelerated the pace of research on lymphatic vessel development. These new tools have facilitated both work in classical mammalian models and the emergence of new powerful vertebrate models like zebrafish, quickly driving the field of lymphatic development back into the spotlight. In this review, we summarize the highlights of recent research on the development and function of the lymphatic vascular network in health and disease. WIREs Dev Biol 2016, 5:689-710. doi: 10.1002/wdev.246 For further resources related to this article, please visit the WIREs website.

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MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

Cited by 65 publications

References 60 publications

New insights into mononuclear phagocyte biology from the visual system

New insights into mononuclear phagocyte biology from the visual system

Integrated functions of membrane‐type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase

Building the drains: the lymphatic vasculature in health and disease

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