MTHFR C677T polymorphism and cerebrovascular lesions in elderly patients with CSVD: A correlation analysis

Abstract

Plasma homocysteine (Hcy) has been identified as a potential risk factor for cerebral small vessel disease. Cerebral small vessel disease (CSVD) leads to cognitive impairment, depression, and other symptoms and is a common disease in middle-aged and elderly people. To investigate the relationship between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and CSVD in elderly patients, plasma levels of homocysteine (Hcy) and MTHFR genotyping were assessed. MRI and MRA were performed at the same time to analyze the relationship between different genotypes and cerebrovascular lesions. We showed that Hcy plasma levels in the TT group were significantly higher than those in the CC and CT groups. Moreover, we observed that the severity of white matter lesions was associated with women and positively correlated with age, previous coronary heart disease, luminal infarction, and MTHFR polymorphism. The multivariate logistic regression analysis showed that age, TT genotype, and lacunar infarction were independent risk factors for white matter hyperintensity (WMH). Importantly, we showed that there was a significant correlation between Hcy plasma levels and MTHFR gene polymorphism, with the TT genotype constituting an independent risk factor for WMH. Therefore, we recommended early detection of MTHFR gene polymorphisms with concomitant early intervention concerning risk factors to delay the occurrence of cognitive impairment in CSVD elderly patients.

Association between MTHFR C677T polymorphism and cognitive impairment in patients with cerebral small vessel disease: a cross-sectional study

“…The linkage between the MTHFR gene and elevated homocysteine levels has been widely acknowledged, and the relationship between genetically-mediated HHcy and cerebrovascular diseases represented a major focus of current clinical research ( Li et al, 2022 ). The MTHFR C677T mutation included three polymorphisms (wild-type CC, heterozygous CT, and homozygous TT).…”

“…Notably, homocysteine levels are susceptible to various external factors, including lifestyle and environmental influences, making it an unstable marker for early detection. Recent studies have indicated that the TT genotype is an independent risk factor for WMH ( Li et al, 2022 ). A meta-analysis of 36 prospective studies demonstrated that WMH is associated with increased risk of cognitive impairment, serving as a neuroimaging marker for dementia ( Hu et al, 2021 ).…”

Development and validation of nomograms to predict the survival probability and occurrence of a second primary malignancy of male breast cancer patients: a population-based analysis

“…( 23 ). However, as we mentioned above, applying only Cox regression analysis was inadequate and would overestimate the risk of cancer-specific death, because aside from the primary tumor, there were other factors that might threaten their life ( 24 ), and death due to other causes actually acted as a competing event to death caused by MBC. In this study, two nomograms were constructed to predict the survival probability of MBC patients based on the Fine and Gray competing risk analysis and multivariate Cox regression, respectively, to correct this bias.…”

Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk

“…A total of nineteen articles were included and 6941 hepatocellular carcinoma patients and 9436 healthy controls were enrolled [13,29,[32][33][34][43][44][45][46][47][48][49][50][51][52][53][54][55][56] (The flow chat of literature selection was showed in Figure 1 and Table S1 (see Table S1, Supplemental Digital Content, which showed the flow chat of literature selection, http://links.lww.com/MD/G441). The characteristics of the included studies were showed in Table 1.…”