2019
DOI: 10.1016/j.fertnstert.2019.01.016
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MTHFR C677T polymorphism is associated with follicle-stimulating hormone levels and controlled ovarian hyperstimulation response: a retrospective study from the clinical database

Abstract: This genetic association study included 722 infertile women who received the standard long treatment protocol with accessible and complete electronic medical records. Intervention(s): None. Main Outcome Measure(s): The clinical parameters were obtained from the Intravenous Infusion Safety Evaluation center. Result(s): Basal FSH levels in the TT group were significantly higher than those of the CC group. The FSH levels after down-regulation in the TT group were higher than those of CC/CT genotypes. The TT genot… Show more

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Cited by 7 publications
(3 citation statements)
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References 45 publications
(46 reference statements)
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“…In the present study, women with few numbers of oocytes following ovarian stimulation (POR) had a higher distribution of minor C-allele in rs1801131 and T-allele in rs1801133 polymorphisms. In agreement with our findings, several observations found a higher prevalence of the MTHFR rs1801131 alleles in patients with diminished response to ovarian stimulation [12,33]. These data, however, was not replicated in another study in COS outcomes [1].…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…In the present study, women with few numbers of oocytes following ovarian stimulation (POR) had a higher distribution of minor C-allele in rs1801131 and T-allele in rs1801133 polymorphisms. In agreement with our findings, several observations found a higher prevalence of the MTHFR rs1801131 alleles in patients with diminished response to ovarian stimulation [12,33]. These data, however, was not replicated in another study in COS outcomes [1].…”
Section: Discussionsupporting
confidence: 85%
“…However, in contrast to these polymorphisms, no association has so far been reported between anti-mullerian hormone type II receptor (AMHR2) SNPs and low or high response in controlled ovarian hyperstimulation [11]. Also, variations in methylenetetrahydrofolate reductase (MTHFR) are associated with follicle-stimulating hormone levels as well as diminished ovarian response to FSH stimulation and failing cycles of IVF in COS [12][13][14][15]. A link has also been shown between estrogen agonist and levels of endothelial plasminogen activator inhibitor (SERPINE1) [16].…”
Section: Introductionmentioning
confidence: 99%
“…According to previous studies, MTHFR genotype mutations are associated with miscarriage and RPL [16,[28][29][30]. Moreover, MTHFR polymorphisms are also involved in poor ovarian stimulation responses in ART treatment [31], and folic acid supplementation improves ovulation disorders [32]. However, there were no significant differences in the miscarriage rate, length of menstruation cycle and rate of ovulation disorders in the three groups in our study.…”
Section: Discussionmentioning
confidence: 38%