mTHPC‐mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients

D’Cruz, Anil; Robinson, Martin; Biel, Merrill A.

doi:10.1002/hed.10372

Cited by 164 publications

(127 citation statements)

References 17 publications

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“…Radiotherapy is associated with a number of distressing or disabling side effects including xerostomia, mucositis, loss of taste and smell, laryngeal dysfunction, skin erythema and it may also cause skin breakdown or osteonecrosis [1]. For recurrent cancer of head and neck, radiotherapy has often been used for the first treatment and therefore, can not be used again.…”

Section: Fig 2 Récidive D'un Carcinome éPidermoïde Du Voile Du Palamentioning

confidence: 99%

“…The incidence varying from 5% in developed countries to as high as 30% in developing countries [1]. Over 90% of these cancers consist of squamous cell carcinoma [2].…”

mentioning

confidence: 99%

“…Squamous cell carcinoma is an extremely aggressive disease. Estimated tumour doubling times range from 9.5 to 320 days, with local recurrences growing faster [1]. Standard treatment for these tumours is surgery and/or radiotherapy and/or chemotherapy.…”

mentioning

confidence: 99%

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Photodynamic therapy as salvage treatment for recurrent head and neck cancer

Gangloff

Phulpin

Cortese

et al. 2012

Med Buccale Chir Buccale

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-Head and neck cancers often lead to disfiguration or functional impairments after treatment. Local recurrence occurs in around 60% of cases and most of them can not be retreated. Photodynamic therapy (PDT) can be an alternative treatment. In a serie of 10 patients with recurrent squamous cell carcinoma of the head and neck that have failed prior therapies and are unsuitable for conventional curative therapy, PDT treatment has been used. Eight patients have shown complete cicatrisation. Seven patients were cured after the follow up period up to 53 months. Three patients died (one outside etiology). Quality of life was considered as very much for 6 out of 10 patients, quite a bit for 1 patient, a little for 2 patients and not at all for 1 patient. Clinical benefit was evaluated as very much for 6 patients out of 10, quite a bit for 2 patients, a little for 1 patient and not at all for 1 patient. PDT can be proposed to patients with head and neck cancer in palliative situation. It could be a therapeutic solution for selected cases with good outcomes. PDT offers patients a unique chance of remission and increased life expectancy compared with palliative treatments.Résumé -La thérapie photodynamique comme traitement de sauvetage pour les récidives des cancers des voies aéro-digestives supérieures. Les cancers de la tête et du cou conduisent souvent à des séquelles esthétiques ou fonctionnelles majeures après traitement. Des récidives locales sont observées dans environ 60 % des cas et la majorité ne peut pas être retraitée à nouveau. La thérapie photodynamique (PDT) peut être une possibilité de prise en charge alternative. Dans une série de 10 patients présentant une récidive d'un carcinome épidermoïde des voies aéro-digestives supérieures qui n'est plus accessible à traitement curatif conventionnel, la PDT a été utilisée. Huit patients ont montré une cicatrisation complète. Sept patients étaient considérés comme guéris après une période de surveillance allant jusqu'à 53 mois. Trois patients sont décédés (dont un d'une cause extérieure au contexte carcinologique). La qualité de vie a été considérée comme très bonne pour 6 patients sur 10, bonne pour 1 patient, moyenne pour 2 patients et mauvaise pour 1 patient. La PDT est une option thérapeutique qui peut être proposée aux patients atteints de cancers des voies aéro-digestives supérieures et placés en situation de prise en charge palliative. Cela pourrait être une possibilité de prise en charge pour des patients bien sélectionnés qui permettrait d'obtenir de bons résultats. La PDT a offert à ces patients une chance unique de rémission de la maladie et a amélioré indéniablement le taux de survie par rapport à la prise en charge palliative qui était la seule alternative.Key words: head and neck cancer / photodynamic therapy / salvage therapy / photosensitizers / squamous cell carcinoma

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Section: Fig 2 Récidive D'un Carcinome éPidermoïde Du Voile Du Palamentioning

confidence: 99%

“…The incidence varying from 5% in developed countries to as high as 30% in developing countries [1]. Over 90% of these cancers consist of squamous cell carcinoma [2].…”

mentioning

confidence: 99%

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Photodynamic therapy as salvage treatment for recurrent head and neck cancer

Gangloff

Phulpin

Cortese

et al. 2012

Med Buccale Chir Buccale

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“…The laser energy can be delivered via interstitial fiber optics using drugs activated by photo-chemical and photo-thermal energy as a potential less invasive treatment alternative for cancer (Paiva et al, 2005c;Paiva et al, 1997;Graeber et al, 1999). Moreover, there has been no generally accepted standard of care for recurrent head and neck cancer (Goodwin et al, 2000;D'Cruz et al, 2004;Arnold et al, 2004;Fury et al, 2011). At UCLA, Phase I and II clinical trials have been conducted using LITT in a stepwise fashion to palliate patients with advanced and recurrent head and neck tumors as an alternative to more radical and at times disabling surgery Paiva et al, 1998a;.…”

Section: Photo-chemical and Photo-thermal Activation Of Anti-cancer Dmentioning

confidence: 99%

“…For the past 50 years, several laser technologies have been employed in surgical oncology, including CO 2 laser for cutting and coagulating and laser-induced thermal therapy (LITT) for thermal ablation of cancer. Photodynamic therapy (PDT) is an approach which has a wide range of application from acne to wrinkles, bactericidal cleansing, cancer treatment, etc (D'Cruz et al, 2004). In PDT, the absorption of photons by organic compounds can excite orbital electrons and increase kinetic energy levels leading to chemical reactions, but also may include light emission as fluorescence or transfer energy directly to oxygen molecules forming singlet and free radical species (Carmichael et al, 1983;Paiva et al, 1996).…”

Section: Introductionmentioning

confidence: 99%