MTNR1B gene variations and high pre-pregnancy BMI increase gestational diabetes mellitus risk in Chinese women

Zhang, Yi; Zhao, Kai; Jin, Lei; Zhou, Yuanzhong; Shang, Xuejun; Wang, Xin; Yu, Hongsong

doi:10.1016/j.gene.2023.148023

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The placental expression level of MT2 in GDM women carrying the GG and GC genotypes was higher than in those carrying the CC genotype [95]. SNPs rs1387153 (C > T) allele T and rs10830962 (C > G) allele G are both located in the intergenic region over 2 kb upstream from MTNR1B and demonstrated a significant association with an increased risk of GDM [96,[98][99][100][101]. Notably, maternal rs10830963 (C > G) had an association with offspring birth weight [13,102].…”

Section: Mtnr1bmentioning

confidence: 96%

“…No statistically significant differences were observed in the distribution of MTNR1B rs4753426 genotypes and alleles between women with GDM and healthy pregnant women in a study conducted on the Caucasian population [66]. However, rs4753426 minor allele C was associated with susceptibility to GDM [96,98], and another study demonstrated that major allele T was a protective variant for GDM development [99].…”

Section: Mtnr1bmentioning

confidence: 96%

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Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

Suthon,

Tangjittipokin

2024

IJMS

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Gestational diabetes mellitus (GDM) is a significant pregnancy complication linked to perinatal complications and an elevated risk of future metabolic disorders for both mothers and their children. GDM is diagnosed when women without prior diabetes develop chronic hyperglycemia due to β-cell dysfunction during gestation. Global research focuses on the association between GDM and single nucleotide polymorphisms (SNPs) and aims to enhance our understanding of GDM’s pathogenesis, predict its risk, and guide patient management. This review offers a summary of various SNPs linked to a heightened risk of GDM and explores their biological mechanisms within the tissues implicated in the development of the condition.

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Section: Mtnr1bmentioning

confidence: 96%

Section: Mtnr1bmentioning

confidence: 96%

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

Suthon,

Tangjittipokin

2024

IJMS

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Preliminary Investigation of Potential Early Biomarkers for Gestational Diabetes Mellitus: Insights from PTRPG and IGKV2D-28 Expression Analysis

Payot,

Villavieja,

Pineda-Cortel

2024

IJMS

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Gestational diabetes mellitus (GDM) poses significant health risks to both mothers and infants, emphasizing the need for early detection strategies to mitigate its impact. However, the existing diagnostic methods, particularly the oral glucose tolerance test (OGTT) administered in the second or third trimester, show limitations in the detection of GDM during its early stages. This study aimed to explore the potential of the genes Protein Tyrosine Phosphatase Receptor-type Gamma (PTPRG) and Immunoglobulin Kappa Variable 2D-28 (IGKV2D-28) as early indicators for GDM among Filipino pregnant women. Utilizing reverse transcription–quantitative polymerase chain reaction (RT-qPCR), the gene expressions were analyzed in first-trimester blood samples obtained from 24 GDM and 36 non-GDM patients. The diagnostic performance of PTPRG and IGKV2D-28 was analyzed and evaluated using receiver operating characteristic (ROC) curves. The findings revealed elevated expression levels of PTPRG and IGKV2D-28 within the GDM cohort. Remarkably, PTPRG exhibited a sensitivity of 83%, while IGKV2D-28 demonstrated a specificity of 94% at determined cut-off values. Combining both genes yielded an improved but limited diagnostic accuracy with an area under the curve (AUC) of 0.63. This preliminary investigation of PTPRG and IGKV2D-28 sheds light on novel avenues for early GDM detection. While these findings are promising, further validation studies in larger cohorts are necessary to confirm these results and explore additional biomarkers to enhance diagnostic precision in GDM pregnancies and, ultimately, to improve maternal and fetal outcomes.

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MTNR1B gene variations and high pre-pregnancy BMI increase gestational diabetes mellitus risk in Chinese women

Cited by 2 publications

References 41 publications

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

Preliminary Investigation of Potential Early Biomarkers for Gestational Diabetes Mellitus: Insights from PTRPG and IGKV2D-28 Expression Analysis

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