2021
DOI: 10.1038/s41385-021-00377-8
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mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

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Cited by 15 publications
(35 citation statements)
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“…In the present study, we analyzed the immune modulating properties of a flagellin:antigen fusion protein on epithelial cells. While the effects of flagellin on epithelial cells are well-known [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ] and the interaction of flagellin with epithelial cells has often been described as a key factor for its adjuvant activity [ 52 ], our study is the first to characterize the response of epithelial cells to a flagellin:antigen fusion protein. We could show that, upon stimulation with a flagellin:antigen fusion protein, epithelial cells can modulate pro-inflammatory mDC responses by a both p38 MAPK- and COX2-dependent production of PGE 2 .…”
Section: Discussionmentioning
confidence: 99%
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“…In the present study, we analyzed the immune modulating properties of a flagellin:antigen fusion protein on epithelial cells. While the effects of flagellin on epithelial cells are well-known [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ] and the interaction of flagellin with epithelial cells has often been described as a key factor for its adjuvant activity [ 52 ], our study is the first to characterize the response of epithelial cells to a flagellin:antigen fusion protein. We could show that, upon stimulation with a flagellin:antigen fusion protein, epithelial cells can modulate pro-inflammatory mDC responses by a both p38 MAPK- and COX2-dependent production of PGE 2 .…”
Section: Discussionmentioning
confidence: 99%
“…Several studies reported flagellin to induce the secretion of chemokines (IL-8, CXCL1, and CCL20) and cytokines (TGF-β1, G-CSF, GM-CSF, and IL-6) from both airway and intestinal epithelial cells [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Mechanistically, flagellin-induced CCL20, TGF-β1, IL-8, and IL-6 production from epithelial cells were shown to be both MAPK- [ 44 , 45 , 50 , 53 ] and at least in part NF κ B-dependent [ 51 , 53 , 54 ].…”
Section: Discussionmentioning
confidence: 99%
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“…A pathologist resected the healthy tracheobronchial tissue distant from tumorous tissue and assessed the absence of malignant cells via microscopy. HBE cells were isolated according to Fulcher's protocol [12], as described before [10]. Briefly, passage 2 (P2) to P4 cells were used for differentiation in 24-well Transwell inserts (Corning, Corning, NY, USA) treated with human type IV placental collagen in submerged PneumaCult-Ex Plus media (StemCell Technologies, Vancouver, BC, Canada).…”
Section: Hbe Cell Differentiationmentioning
confidence: 99%
“…We recently demonstrated that, besides different leukocyte subsets, primary human bronchial epithelial (HBE) cells also utilize glycolysis to produce immune mediators after stimulation with flagellin [10]. Here, we aimed to investigate the impact of HIF1α stabilization on the metabolism and function of primary HBE cells in response to flagellin.…”
Section: Introductionmentioning
confidence: 99%