mTOR signaling: new networks for ALL

Fruman, David A.

doi:10.1182/blood-2016-03-703199

Cited by 5 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Except that, identi ed unigenes were assigned to other signaling pathways, such as ErbB, P53, mTOR and Notch signaling pathways. Accumulating evidences have demonstrated that mTOR and Notch pathway has a central role not only for cell growth, but also for invasion and metastasis of tumors [20,21]. The present results showed that mTOR and Notch pathway might be active in D. salina cell during the agellar assembly.…”

Section: Discussionsupporting

confidence: 56%

Differential transcriptome analysis of Dunaliella salina during flagellar assembly

Zhu

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Eukaryotic flagellum is highly conserved in basic structure and biogenesis, and defects in ciliary assembly or function lead to a wide range of human disease symptoms. The alga Dunaliella salina (D. salina), provides an excellent model for investigating flagellar/ciliary system. However, the genomes it carries is unpublished. Results In this study, using high-throughput illumina RNA sequencing, the transcriptomes from flagella-assembling D. salina were analyzed firstly at an unprecedented depth. About 4 gigabases of raw sequence data were generated and 197,295 unigenes were annotated with gene descriptions, conserved protein domains, or gene ontology terms against public databases. Among the annotated unigenes, 25,412 unigenes were differentially expressed during flagella regeneration, including 9,988 up-regulated unigenes and 15,407 down-regulated unigenes. Moreover, to functionally categorize the D. salina unigenes, the differentially expressed unigenes distributed into the category of biological process, molecular function and cellular component. These transcriptome datasets might reveal the mechanism of flagella assembly in D. salina cells, and serve as a public information platform for D. salina functional genomics and proteomics analysis. Furthermore, the differentially expressed unigenes involved in different signaling pathways of D. salina flagella assembly and human diseases were screened respectively. Conclusion These pathway-based results not only provide a further understanding to specific processes of ciliogenesis and ciliopathies, but also offer a cue to mechanism of human diseases.

show abstract

Section: Discussionsupporting

confidence: 56%

Differential transcriptome analysis of Dunaliella salina during flagellar assembly

Zhu

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…mTOR is involved in a series of physiological pathological processes in cells in two main forms: mTOR-Raptor complex (mTORC1) and mTOR-Rictor complex (mTORC2). [53,54] The mTORC1 complex mainly affects cell growth and proliferation by regulating protein synthesis, and its activity can be inhibited by rapamycin. [55] The activity of the mTORC2 complex cannot be inhibited by rapamycin and is mainly involved in the construction of cytostoproteins.…”

Section: Discussionmentioning

confidence: 99%

ATL1 inhibits the proliferation and invasion of trophoblast cells via inhibition of the mTOR signaling pathway

Zhang

Feng

Wang

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Pre‐eclampsia (PE) is a major cause of hypertension in maternal and fetal. Atlastin‐1 (ATL1), one regulator of endoplasmic reticulum (ER) morphology, participates in tubular ER formation and protein synthesis. The objective of this study is to investigate the role and molecular mechanism of ATL1 in PE. GEO databases showed that ATL1 was upregulated in PE patients. Our data also found that ATL1 was highly expressed in PE placental tissues. The cell viability, proliferation, migration, and invasion of HTR‐8/SVneo cells increased/decreased after the downregulation/upregulation of ATL1. The mTOR pathway is the downstream pathway of ATL1. The levels of p‐p70S6K and p‐mTOR were increased/decreased after the downregulation/upregulation of ATL1. Moreover, rapamycin, an inhibitor of mTOR pathway, reversed the promotive effect of siATL1 on proliferation, migration, and invasion in HTR‐8/SVneo cells. In conclusion, ATL1 inhibits the proliferation and invasion of trophoblast cells via the inhibition of the mTOR signaling pathway in HTR‐8/SVneo cells.

show abstract

“…Supplementary Materials:The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/ijms241512164/s1. References[64,[86][87][88][89][90][91][92][93] are cited in the supplementary materials.…”

mentioning

confidence: 99%

Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Usenko

Bezrukova

Rudenok

et al. 2023

IJMS

View full text Add to dashboard Cite

Mutations in the GBA1 gene represent the major genetic risk factor for Parkinson’s disease (PD). The lysosomal enzyme beta-glucocerebrosidase (GCase) encoded by the GBA1 gene participates in both the endolysosomal pathway and the immune response. Disruption of these mechanisms is involved in PD pathogenesis. However, molecular mechanisms of PD associated with GBA1 mutations (GBA-PD) are unknown today in particular due to the partial penetrance of GBA1 variants in PD. The modifiers of GBA1 penetrance have not been elucidated. We characterized the transcriptomic profiles of cells from the substantia nigra (SN) of mice with co-injection with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and selective inhibitor of GCase activity (conduritol-β-epoxide, (CBE)) to mimic PD bearing GCase dysfunction (MPTP+CBE), mice treated with MPTP, mice treated with CBE and control mice treated with injection of sodium chloride (NaCl) (vehicle). Differential expression analysis, pathway enrichment analysis, and outlier detection were performed. Functional clustering of differentially represented transcripts revealed more processes associated with the functioning of neurogenesis, inflammation, apoptosis and autophagy in MPTP+CBE and MPTP mice than in vehicle mice, with a more pronounced alteration of autophagy processes in MPTP+CBE mice than in MPTP mice. The PI3K-Akt-mTOR signaling pathway may be considered a potential target for therapy in PD with GCase dysfunction.

show abstract

mTOR signaling: new networks for ALL

Cited by 5 publications

References 10 publications

Differential transcriptome analysis of Dunaliella salina during flagellar assembly

Differential transcriptome analysis of Dunaliella salina during flagellar assembly

ATL1 inhibits the proliferation and invasion of trophoblast cells via inhibition of the mTOR signaling pathway

Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Contact Info

Product

Resources

About