2017
DOI: 10.1016/j.celrep.2017.08.046
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mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages

Abstract: Summary Tissue-resident macrophages play critical roles in sentinel and homeostatic functions as well as promoting inflammation and immunity. It has become clear that the generation of these cells is highly dependent upon tissue-specific cues derived from the microenvironment that in turn regulate unique differentiation programs. Recently, a role for GATA6 has emerged in the differentiation programming of resident peritoneal macrophages. We identify a critical role for mTOR in integrating cues from the tissue … Show more

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Cited by 50 publications
(52 citation statements)
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“…The expansion of adipose tissue is linked to adipocyte hypertrophy and hyperplasia, an increase in macrophage accumulation, and production of pro-inflammatory cytokines that characterize the systemic inflammation observed in obesity (Apovian et al, 2008;Caesar et al, 2012;Oh et al, 2017). In this study, the intake of a high-fat diet resulted in an increased adipocyte size along with an elevated presence of macrophages.…”
Section: Discussionmentioning
confidence: 69%
“…The expansion of adipose tissue is linked to adipocyte hypertrophy and hyperplasia, an increase in macrophage accumulation, and production of pro-inflammatory cytokines that characterize the systemic inflammation observed in obesity (Apovian et al, 2008;Caesar et al, 2012;Oh et al, 2017). In this study, the intake of a high-fat diet resulted in an increased adipocyte size along with an elevated presence of macrophages.…”
Section: Discussionmentioning
confidence: 69%
“…The cellular metabolism is orchestrated by essential intracellular signaling cascades, for instance, by the mTOR signaling pathway. It has been described, that both, mTORC1 and mTORC2, respond to the polarization of M2 macrophages in parasite infection and tumor models (Covarrubias et al , ; Hallowell et al , ; Oh et al , ). It has been demonstrated, that the mTORC2‐IRF4 axis controls the IL‐4‐induced M2 macrophage differentiation in a STAT6‐independent way.…”
Section: Discussionmentioning
confidence: 99%
“…85 Inhibition of mTORC2 promotes generation of tissue-resident macrophages via induction of FOXO1 and GATA6. 86 Apart from playing a central role in sensing and integrating environmental cues in order to regulate macrophage effector function, mTOR also modulates T reg cell differentiation, activation and function. Inhibition of mTOR during T cell activation favored the generation of a specific subset of memory-like T reg cells with a similar metabolic phenotype to CD8 + memory cells.…”
Section: Metforminmentioning
confidence: 99%