MTX-Intoleranz bei Kindern und Jugendlichen mit juveniler idiopathischer Arthritis

High Efficacy Combined Microneedles Array with Methotrexate Nanocrystals for Effective Anti-Rheumatoid Arthritis

“…The main dosage forms of MTX that are used clinically are tablets and injections. 10–13 Long-term oral administration of MTX can result in adverse reactions such as digestive tract problems, 14 , 15 myelosuppression, 16 , 17 and abnormal liver and kidney function. 18 , 19 Moreover, MTX injection must be administered by healthcare professionals and the needles used are a biohazard.…”