Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Li, Chunyan; Liu, Zheshuo; Yan, Xueying; Lu, Weiyue; Liu, Yu

doi:10.1016/j.ijpharm.2014.12.011

Cited by 20 publications

(19 citation statements)

References 14 publications

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“…PBNP-S were synthesized as described in previous reports 18,23 except that SSS was included in the polymerization at the weight ratio in the total monomers of 5% (the product nanoparticles named as PBNP-S5) and 10% (as PBNP-S10). Briefly, in a 250 mL round-bottom flask equipped with a stirrer (MS-H-Pro + stirrer; Dragon Lab Inc., Beijing, People's Republic of China) and a N 2 gas inlet, 100 mL SDS solution (0.053%, w/v) was heated to 30°C, followed by the addition of VPBA (0.970 g) and appropriate amounts of SSS, MBAAm and EGDMA under stirring.…”

Section: Preparation Of Pbnp-smentioning

confidence: 99%

“…Release of FITC-IFN was conducted in the vaginal fluid stimulant containing mucin at a physiological level (1.5%, w/v) or without in a shaking bath at 37°C for 3 days. 18 FITC-IFN concentration in the release samples was determined by fluorescent spectrophotometry at E x 495 nm and E m 520 nm with a microplate reader (Synergy 2; Bio-Tek Co., Winooski, VT, USA) to calculate the accumulative FITC-IFN release percentage relative to the loading amount at each time point.…”

Section: Drug Loading and Releasementioning

confidence: 99%

“…18 Sulfonated monomers were included to confer the product nanoparticles negative charges for better stability. Two types of PBNP-S were prepared, differing in the ratio of sulfonated monomers in the total input amount of monomers and cross-linkers …”

Section: Preparation and Characterization Of Pbnp-smentioning

confidence: 99%

“…18 However, the stability of PBNPs is not satisfactory because their tendency to aggregate over time or at neutral pH severely limited manipulation, long-term storage and future expansion of application.…”

mentioning

confidence: 99%

“…But conventional semi-solid formulations leak quickly from the vagina and usually require repeated administration, practical inconvenience and poor compliance of patients. 18,34 Therefore, IFN was used in the present investigation as the model protein therapeutics to achieve prolonged intravaginal placement and thus better patient compliance. The adsorption of IFN by PBNPs or PBNP-S may be at least partially attributed to electronic interaction.…”

mentioning

confidence: 99%

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Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement

Li¹,

Huang²,

Liu³

et al. 2016

IJN

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Section: Preparation Of Pbnp-smentioning

confidence: 99%

Section: Drug Loading and Releasementioning

confidence: 99%

Section: Preparation and Characterization Of Pbnp-smentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement

Li¹,

Huang²,

Liu³

et al. 2016

IJN

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Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system

Huang

Liu

et al. 2017

Acta Pharmaceutica Sinica B

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Lack of mucoadhesive properties is the major drawback to poloxamer 407 (F127)-based in situ hydrogels for mucosal administration. The objective of the present study was to construct a novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system based on an amino-functionalized poloxamer for vaginal administration. First, amino-functionalized poloxamer 407 (F127-NH2) was synthesized and characterized with respect to its micellization behavior and interaction with mucin. Then using acetate gossypol (AG) as model drug, AG-loaded F127-NH2-based in situ hydrogels (NFGs) were evaluated with respect to rheology, drug release, ex vivo vaginal mucosal adhesion, in vivo intravaginal retention and local irritation after vaginal administration to healthy female mice. The results show that F127-NH2 is capable of forming a thermosensitive in situ hydrogel with sustained drug release properties. An interaction between positively charged F127-NH2 and negatively charged mucin was revealed by changes in the particle size and zeta potential of mucin particles as well as an increase in the complex modulus of NFG caused by mucin. Ex vivo and in vivo fluorescence imaging and quantitative analysis of the amount of AG remaining in mouse vaginal lavage all demonstrated greater intravaginal retention of NFG than that of an unmodified F127-based in situ hydrogel. In conclusion, amino group functionalization confers valuable mucoadhesive properties on poloxamer 407.

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Exploration and exploitation of the uncommon pH profile of the dynamic covalent interactions between boronic acids and N-acetylneuraminic acids

Peters

Djanashvili

2023

Coordination Chemistry Reviews

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Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Cited by 20 publications

References 14 publications

Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement

Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement

Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system

Exploration and exploitation of the uncommon pH profile of the dynamic covalent interactions between boronic acids and N-acetylneuraminic acids

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