Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Aksoy, Nurten; Akinci, Ömer Faruk

doi:10.1002/mabi.200300099

Cited by 28 publications

(26 citation statements)

References 170 publications

(483 reference statements)

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“…For example, we identified insertions in two different putative mucin-encoding genes. Mammalian mucins are secreted glycoproteins that are widely implicated in tumor cell adhesion but have no previously identified role in the nervous system [40]. Are these false positives or important insights into postsynaptic development?…”

Section: Discussionmentioning

confidence: 99%

Genes involved in Drosophilaglutamate receptor expression and localization

Liebl

Featherstone

2005

BMC Neurosci

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Background: A clear picture of the mechanisms controlling glutamate receptor expression, localization, and stability remains elusive, possibly due to an incomplete understanding of the proteins involved. We screened transposon mutants generated by the ongoing Drosophila Gene Disruption Project in an effort to identify the different types of genes required for glutamate receptor cluster development.

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Section: Discussionmentioning

confidence: 99%

Genes involved in Drosophilaglutamate receptor expression and localization

Liebl

Featherstone

2005

BMC Neurosci

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“…MUC have been regarded as a universal characteristic of the malignant transformation of cells. Alterations of MUC are considered to be relevant to the abnormal behavior of cancer cells, such as altered cell adhesion or metastasis, and to the avoidance of immunological defense [5]. Previous studies demonstrated that MUC1, a transmembrane mucin, as detected immunologically, is increased in expression in colon cancers, and correlates with a worse prognosis [6].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Expression of Resistin-like Molecule Beta in Human Colon Cancer and Its Clinical Significance

et al. 2008

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Previous studies have indicated that resistin-like molecule beta (RELM beta), an intestinal goblet cell-specific protein, is markedly increased in the intestinal tumors of min mice and over-expressed in a human colon cancer cell line. We hypothesized that RELM beta might be enhanced in human colon cancer. The aim of this study was to examine the clinical importance of RELM beta expression in colon cancer patients and to correlate its expression with various clinicopathological parameters, upstream regulatory molecule expression, tumor proliferative capacity, and patients' survival. Of the 80 colon cancer patients studied, 65 (81.25%) tested positive for RELM beta, mainly in the cytoplasm of colon mucosa. Contrasting sharply with the strongly RELM beta-positive tumors, normal colon mucous membrane was negative or weakly positive. RELM beta positivity in colon cancer was correlated with histological grade of differentiation and lymph node metastasis, but not with age, gender, tumor location and size, tumor infiltration, Dukes' stage, liver metastasis, and venous invasion. RELM beta expression was significantly correlated with the expression of transcription factor CDX-2 (P < 0.01) but not with that of proliferative index Ki-67 (P > 0.05). The mean postoperative survival time (2.76 years) of RELM beta-positive patients was significantly longer than that (1.26 years) of RELM beta-negative patients (P = 0.032). These findings support evidence of the enhanced RELM beta expression in colon cancer patients and suggest that further investigation is warranted to explore the role of RELM beta in colon cancer.

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“…Mucus is composed of a complex mixture of water, electrolytes, desquamated cells, cellular macromolecules and glycoproteins (Aksoy and Akinsi, 2004).…”

Section: Introductionmentioning

confidence: 99%