Mucin-producing carcinoid (“composite tumor”) of upper third of esophagusA variant of carcinoid tumor

Chong, Frank K.; Graham, James H.; Madoff, Irving M.

doi:10.1002/1097-0142(197911)44:5<1853::aid-cncr2820440544>3.0.co;2-d

Cited by 61 publications

(28 citation statements)

References 24 publications

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“…Other names used to diagnose such tumors include mucin-producing carcinoid [47], composite carcinoid-adenocarcinoma [48,49], composite carcinoid tumor [50], mixed adenocarcinoid tumor [51], and composite glandular-neuroendocrine mixed tumor [30]. These neoplasms have been reported in the esophagus [47,52], stomach [18,48,53,54,55], ampulla of Vater [49,56], ileum [51], and large bowel [30,50,57,58,59,60,61]. To date, about 60 cases have been reported in the literature.…”

Section: Mixed Adenoneuroendocrine Carcinomas (Manecs)mentioning

confidence: 99%

Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update

Rosa

Marando

Sessa

et al. 2012

Cancers

244

307

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The systematic application of immunohistochemical techniques to the study of tumors has led to the recognition that neuroendocrine cells occur rather frequently in exocrine neoplasms of the gut. It is now well known that there is a wide spectrum of combinations of exocrine and neuroendocrine components, ranging from adenomas or carcinomas with interspersed neuroendocrine cells at one extreme to classical neuroendocrine tumors with a focal exocrine component at the other. In addition, both exocrine and neuroendocrine components can have different morphological features ranging, for the former, from adenomas to adenocarcinomas with different degrees of differentiation and, for the latter, from well differentiated to poorly differentiated neuroendocrine tumors. However, although this range of combinations of neuroendocrine and exocrine components is frequently observed in routine practice, mixed exocrine-neuroendocrine carcinomas, now renamed as mixed adenoneuroendocrine carcinomas (MANECs), are rare; these are, by definition, neoplasms in which each component represents at least 30% of the lesion. Gastrointestinal MANECs can be stratified in different prognostic categories according to the grade of malignancy of each component. The present paper is an overview of the main clinicopathological, morphological, immunohistochemical and molecular features of this specific rare tumor type.

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Section: Mixed Adenoneuroendocrine Carcinomas (Manecs)mentioning

confidence: 99%

Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update

Rosa

Marando

Sessa

et al. 2012

Cancers

244

307

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“…The overall survival of patients with poorly differentiated carcinomas is usually less than 6 months [68,83]. Mixed endocrineexocrine carcinomas of the esophagus show a prognosis similar to that of adenocarcinomas, depending on their histological differentiation and tumor stage [36]. Neither associated diseases nor inherited syndromes have been reported for NETs/neuroendocrine carcinomas of the esophagus.…”

Section: Esophagusmentioning

confidence: 99%

Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors

et al. 2007

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The gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are composed of cells with a neuroendocrine phenotype. Well-differentiated tumors, well-differentiated carcinomas, poorly differentiated carcinomas, functioning tumors (with a hormonal syndrome), and nonfunctioning tumors are identified. To predict their clinical behavior, these neuroendocrine tumors are classified on the basis of their clinicopathological features, including size, local invasion, angioinvasion, proliferative activity, histological differentiation, and metastases, into neoplasms with benign, uncertain, low-grade malignant and high-grade malignant behavior. In addition, a tumor/nodes/metastases classification and a grading system are presented. In the light of these criteria, the various GEP-NET entities are reviewed.

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“…3,4,6,9,14,23,26 The relative proportion and the degree of differentiation of the glandular and endocrine components in these tumors are highly variable. The histologic spectrum ranges from admixture of well-differentiated glands or goblet cells with typical carcinoid tumor (''adenocarcinoid tumor'' or ''goblet cell carcinoid'') to frank adenocarcinoma containing only scattered endocrine cells.…”

mentioning

confidence: 99%

Composite Glandular and Endocrine Tumors of the Stomach With Pancreatic Acinar Differentiation

Jain¹,

Eslami-Varzaneh²,

Takano³

et al. 2005

The American Journal of Surgical Pathology

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Composite tumors of the stomach consisting of mixed glandular and endocrine components are rare. We report 3 cases of composite glandular and endocrine tumors with pancreatic acinar differentiation in the stomach with their clinicopathologic findings. The patients' presenting symptoms were variable and included abdominal pain, gastrointestinal hemorrhage, and weight loss. One patient with abdominal pain also had an elevated serum lipase level, clinically mimicking acute pancreatitis. The histology of these tumors was similar. They showed admixture of well-differentiated endocrine components with acinar and glandular components. The glandular component consisted of columnar epithelial cells resembling gastric foveolar or intestinal goblet cells, consistent with a well-differentiated adenocarcinoma. A panel of histochemical and immunohistochemical stains was performed, which included PAS, Alcian blue, Mib1, CEA, cytokeratin 7, cytokeratin 20, Muc2, Muc5AC, chromogranin, synaptophysin, trypsin, chymotrypsin, lipase, insulin, gastrin, serotonin, and pancreatic polypeptide. While the immunoreactivity for cytokeratin 7, cytokeratin 20, Muc2, Muc5AC, and CEA was largely restricted to the glandular component, the endocrine and pancreatic acinar markers showed marked variability and overlap. All cases showed immunoreactivity for at least one of the exocrine pancreatic enzymes, and all expressed endocrine differentiation. Some degree of amphicrine differentiation was suggested in all cases. Two cases showed metastases in perigastric lymph nodes, which histologically resembled the primary tumor. In summary, these tumors represent another distinct type of composite glandular and endocrine gastric neoplasm with pancreatic acinar differentiation.

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Mucin-producing carcinoid (“composite tumor”) of upper third of esophagusA variant of carcinoid tumor

Abstract: An unusual upper esophageal polypoid tumor was found to be predominantly a carcinoid tumor and in part a mucin-producing adenocarcinoma. A review of literature showed this to be a unique tumor in this location.

Cited by 61 publications

References 24 publications

Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update

Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update

Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors

Composite Glandular and Endocrine Tumors of the Stomach With Pancreatic Acinar Differentiation

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