Mucin-Producing Poorly Differentiated Adenocarcinoma of the Thyroid

Mizukami, Yuji; Nakajima, Hiroyuki; Annen, Yusei; Michigishi, Takatoshi; Nonomura, Akitaka; Nakamura, Shinobu

doi:10.1016/s0344-0338(11)80381-x

Cited by 28 publications

(27 citation statements)

References 8 publications

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“…The case reports of mucinous thyroid tumors [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27], including the current three cases, are summarized in table 2. The list does not include the mucin-negative signet ring thyroid tumors described by Schröder and Böcker [28] and commented on by LiVolsi [29].…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration of Mucin-Producing Thyroid Tumors

Yang¹,

Scognamiglio²,

Kuhel

2011

Acta Cytologica

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Objective: Mucin-producing thyroid tumors are extremely rare. Nonetheless, we have encountered three such cases in fine-needle aspiration. We report the cytologic and histologic findings and review the literature. Study Design: Cytologic features were studied on direct smears using Romanovsky stain to detect background substance and Papanicolaou stain to analyze nuclear and cytoplasmic features. The cytologic features were correlated with histology. Mucin was demonstrated by mucicarmine, Alcian Blue/PAS, and Alcian Blue (pH 2.5). Results: The cytologic features related to mucin include: (1) thick luminal mucin globules and signet ring cells aspirated from an 83-year-old woman with a 3-cm signet ring cell follicular adenoma, (2) abundant fluffy mucin containing signet ring cells in cohesive fragments aspirated from a 75-year-old man with the bilateral signet ring cell follicular variant of papillary carcinoma, which is the first case in the English literature, and (3) abundant thin mucoid mucin aspirated from the lymph node of an 86-year-old woman with a 5-cm mucinous poorly differentiated thyroid carcinoma. Conclusion: The occurrence of mucin in thyroid fine-needle aspiration does not necessarily indicate metastasis, and the presence of mucin in cervical lymph nodes does not exclude the thyroid gland as a possible primary.

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Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration of Mucin-Producing Thyroid Tumors

Yang¹,

Scognamiglio²,

Kuhel

2011

Acta Cytologica

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“…These tumours do not represent a true primary thyroid mucinous carcinoma. In fact, this latter is extremely rare (only four cases reported), and histologically, it is indistinguishable from a mucinous carcinoma at other sites [3,5,7,9]. In these case, areas of papillary or follicular carcinoma are not always evident.…”

Section: Discussionmentioning

confidence: 92%

“…This latter is exceptionally rare, with only six cases reported in literature, and histologically are indistinguishable from mucinous carcinoma of others sites [3,5,7,9]. We describe two cases of a mucinous tumour of the thyroid where one is a primary carcinoma as demonstrated by immunohistochemistry and the second represents a first clinical manifestation of a mucinous carcinoma of the ovary.…”

Section: Introductionmentioning

confidence: 83%

Mucinous carcinoma of thyroid gland. Report of a primary and a metastatic mucinous tumour from ovarian adenocarcinoma with immunohistochemical study and review of literature

D’Antonio

Addesso²,

Dominicis

et al. 2007

Virchows Arch

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Mucinous carcinoma of the thyroid gland is an uncommon tumour that from the histological point of view, resembles mucinous carcinoma of others sites. Although a mucinous appearance has sometimes been reported in association with cases of typical thyroid carcinoma, true mucinous carcinoma is exceptionally rare. We describe two cases of thyroid tumours with mucinous differentiation studied with immunohistochemistry. Both cases disclosed a similar histological appearance, with small nests and sheets of malignant epithelial cells associated with extensive extracellular mucin that substituted and entrapped the follicular parenchyma of the thyroid. Thyroglobulin and focally thyroid transcription factor (TTF) 1 were positive in one case. From these findings, we classified this tumour as primary mucinous thyroid carcinoma. Thyroglobulin and TTF-1 were negative in tumour cells of second case; on the contrary, positivity to the carcinoembryonic antigen and CA-125 was strong and generalized. However, successfully, the patient presented ascites associated to right ovarian mass. In this case, thyroid tumour represents the first clinical sign of an ovarian mucinous adenocarcinoma, and it has not been previously described in literature. Both patients died after few months to diagnosis. In conclusion, primary and secondary mucinous carcinoma are rare and unusual tumours of the thyroid gland that can be a cause of pitfall in differential diagnosis. In these cases, for a correct diagnosis, a complete clinical history, restricted histological criteria and immunohistochemical panel are necessary.

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“…However, even in other pathological types (papillary, follicular, and anaplastic) of thyroid carcinoma, mucin substances may be commonly observed. 3,4 Oncocytic carcinoma of the thyroid gland, known as Hurthle-cell carcinoma, also shows mucin production. 5,6 Recently, the mucin gene (MUC1) has been recognized in papillary carcinoma, and MUC1 RNA was observed to be overexpressed in comparison to normal thyroid tissues.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Adenoma with Extensive Extracellular Mucin Deposition: Report of a Case

et al. 2007

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A thyroid tumor with extensive extracellular mucin deposition is extremely rare. We herein describe a case of a thyroid adenoma with prominent myxoid stroma. A 63-year-old man presented with a mass in his right anterior neck. Radiological examinations showed this mass to be a thyroid tumor with a cystic component. The histopathological findings showed the stroma of this tumor to consist of abundant myxoid materials which stained gray-bluish for hematoxylin-eosin. The myxoid material was positive for alcian blue, whereas periodic acid-Schiff did not stain this material. No intracytoplasmic mucin was identified. In an immunohistochemical study, the tumor cells were negative for cytokeratin 19. Furthermore, positive staining was observed for thyroglobulin while a negative finding was seen for calcitonin.

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Mucin-Producing Poorly Differentiated Adenocarcinoma of the Thyroid

Cited by 28 publications

References 8 publications

Fine-Needle Aspiration of Mucin-Producing Thyroid Tumors

Fine-Needle Aspiration of Mucin-Producing Thyroid Tumors

Mucinous carcinoma of thyroid gland. Report of a primary and a metastatic mucinous tumour from ovarian adenocarcinoma with immunohistochemical study and review of literature

Thyroid Adenoma with Extensive Extracellular Mucin Deposition: Report of a Case

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