Mucin-producing tumor of the pancreas: diagnostic value of diffusion-weighted echo-planar MR imaging.

Yamashita, Yasuyuki; Namimoto, Tomohiro; Mitsuzaki, Katsuhiko; Urata, Joji; Tsuchigame, Tadatoshi; Takahashi, Manabu; Ogawa, Michio

doi:10.1148/radiology.208.3.9722835

Cited by 71 publications

(52 citation statements)

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“…DW-MRI studies of focal liver masses showed lower apparent diffusion coefficient (ADC) values in malignant masses as compared to benign masses and cysts (17). In another study, DW-MRI showed lower ADC values in mucin-producing tumors of the pancreas and pseudocysts as compared to serous cysts and cerebrospinal fluid (18). This technique was also used to show a significant perfusion contribution to the ADC values in the abdominal organs and hepatic lesions (19).…”

mentioning

confidence: 98%

Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology

Kozłowski

Chang

Jones

et al. 2006

Magnetic Resonance Imaging

245

192

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Purpose:To determine whether the combination of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI provides higher diagnostic sensitivity for prostate cancer than each technique alone. Materials and Methods:Fourteen patients with a clinical suspicion of prostate cancer underwent endorectal MRI on a 1.5T scanner prior to transrectal ultrasound (TRUS)-guided biopsies. The average values of the apparent diffusion coefficient (ADC, calculated from b-values of 0 and 600), K trans , v e , maximum gadolinium (Gd) concentration, onset time, mean gradient, and maximum enhancement were determined. Correlation with histology was based on biopsy (six patients) and prostatectomy specimen (eight patients) results. The Tukey-Kramer test was used for statistical analysis. Results:The average values of all MRI parameters, except v e and maximum Gd concentration, showed significant differences between tumor and normal prostate. The sensitivity and specificity values were respectively 54% (35-72%) and 100% (95-100%) for the ADC data, and 59% (39 -77%) and 74% (63-83%) for the DCE data. When both ADC and DCE results were combined, the sensitivity increased to 87% (68 -95%) and specificity decreased to 74% (62-83%). Conclusion:All but two DW-and DCE-MRI parameters showed significant differences between tumor and normal prostate. Combining both techniques provides better sensitivity, with a small decrease in specificity.

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mentioning

confidence: 98%

Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology

Kozłowski

Chang

Jones

et al. 2006

Magnetic Resonance Imaging

245

192

View full text Add to dashboard Cite

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“…DWI is a primary imaging method which is used in the diagnosis of cerebral infarction. Recently, however it has been used to evaluate other organs such as ovaries, pancreas, prostate and breast (5,(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

The Role of Diffusion Weighted Imaging in the Assessment of Axillary Lymph Nodes

Basara¹,

Örgüç²,

Coşkun³

2013

J Breasth Health

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Objective: Several studies have shown that diffusion weighted imaging (DWI) can serve as a powerful tool for differentiating benign from malignant breast lesions. In addition to this use, DWI may also be used in the assessment of axillary lymph nodes, since they show similar tissue characteristics to the primary tumor. Sonuç: Ön bulgularımıza göre, preoperatif dönemde malign ve benign aksiller lenf nodlarının ayrımında ADC ölçümlerinin kullanışlı olabileceğini önermek-tedir. Geniş serilerle yapılan ileri çalışmalar DAG'deki sonuçlara güveni arttıra-caktır. Materials and MethodsAnahtar sözcükler: Difüzyon ağırlıklı, manyetik rezonans görüntüleme, meme kanseri, lenf nodu

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“…Yamashita et al (9) reported that diffusion-weighted MRI can indicate the presence of mucinous products in the cystic tumor of the pancreas. Mucin is echo-free on sonography, water-attenuating on CT, and shows water signal intensity on T2-weighted MRCP; therefore, intraductal mucin is difficult to detect with conventional noninvasive imaging modalities.…”

Section: Discussionmentioning

confidence: 99%

Gadobenate dimeglumine–enhanced MRI of intraductal papillary mucinous tumor of the bile ducts

Park

Lee

et al. 2007

Magnetic Resonance Imaging

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We present the case of a 63-year-old male with intraductal papillary mucinous tumor (IPMT) of the bile ducts. We discuss the role of gadobenate dimeglumine (Gd-BOPTA)-enhanced T1-weighted MRI in the visualization of mucin flow, localization of the papillary tumor, and confirming the diagnosis of this uncommon disease. MAGNETIC RESONANCE cholangiopancreatography (MRCP) is a noninvasive method for visualizing the pancreatobiliary ductal systems. For conventional MRCP, heavily T2-weighted, fat-suppressed sequences are used, in which the static fluid has a hyperintense signal and the signals of the background, solid mass, and calculi are suppressed.Gadobenate dimeglumine (Gd-BOPTA, MultiHance; Bracco Imaging, Milan, Italy), a new gadolinium-based contrast agent, differs from conventional gadoliniumbased agents in that it possesses a two-fold greater T1 relaxivity in human plasma and it is eliminated from the body through both the renal (95-97% of the injected dose) and hepatobiliary (3-5% of the injected dose) pathways (1,2). Hepatobiliary elimination appears to occur as a result of functioning hepatocytes taking up the Gd-BOPTA chelate of Gd-BOPTA and eliminating it via an anionic transporter across the sinusoidal membrane into the bile (1,2). Therefore, Gd-BOPTA has the potential to generate anatomical and functional T1-weighted MR cholangiographic images. However, its effects on intraductal papillary mucinous tumor (IPMT) of the bile ducts have not yet been explored.The aim of this study was to evaluate the usefulness of Gd-BOPTA-enhanced MR cholangiography in the evaluation of IPMT of the bile ducts. CASE REPORTA 63-year-old man was admitted to our hospital for further evaluation of a bile duct dilatation that was detected incidentally during a routine checkup.Contrast-enhanced computed tomography (CT) scans were performed with a 16-detector row scanner (Somatom Sensation 16, software version VA20; Siemens Medical Solutions, Forchheim, Germany) with the following parameters: detector collimation of 16 ϫ 0.75, table feed of 12 per rotation, section width of 5 mm, reconstruction increment of 5 mm with 5-mm sections, pitch of 1.2; tube current of 120 kVp (phased kilovolts); and 160 mA. Portal phase CT imaging showed severe dilatation of the right and left intrahepatic ducts (Fig. 1a).MRI was performed with a 1.5-T superconducting unit (Magnetom Vision; Siemens Medical Systems, Erlangen, Germany) and a phased-array torso coil. Routine MR cholangiographic sequences were performed using a half-Fourier rapid acquisition with a relaxation enhancement (RARE) sequence with breathholds (TR/ effective TE ϭ infinite/95 msec; matrix size ϭ 240 ϫ 256; field of view ϭ 300 -350 mm). We performed sequential multisection acquisitions (section thickness ϭ 3-5 mm). Dynamic contrast-enhanced MRI was performed using, 3D T1-weighted, fat-saturated, volumetric interpolated breathhold images (VIBE) (TR/TE ϭ 4.2 msec/1.6 msec; flip angle ϭ 12°; matrix size ϭ 205 ϫ 256; field of view ϭ 300 -350 mm; and 24 partitions interpolated to 48 slic...

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Mucin-producing tumor of the pancreas: diagnostic value of diffusion-weighted echo-planar MR imaging.

Abstract: Diffusion-weighted MR imaging can help characterize cystic lesions of the pancreas. Findings-suggestive of viscous fluid in mucin-producing tumors are present on such images.

Cited by 71 publications

References 0 publications

Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology

Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology

The Role of Diffusion Weighted Imaging in the Assessment of Axillary Lymph Nodes

Gadobenate dimeglumine–enhanced MRI of intraductal papillary mucinous tumor of the bile ducts

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