Mucinous adenocarcinoma of the lung in association with congenital pulmonary airway malformation

MUC5AC, cytokeratin 20 and HER2 expression and K‐RAS mutations within mucinogenic growth in congenital pulmonary airway malformations

“… 30 and by our group, 31 KRAS mutations in the mucinogenic nests represent an early event of carcinogenesis. Several examples have been reported in the literature which have suggested that these mucinous cell proliferations in type 1 CPAM may lead to aerogenous invasion of both lungs and distant metastases if not completely excised 32–41 . This may be considered another robust finding in supporting the neoplastic malignant nature of these bland‐appearing, mucinous cell growths.…”

Association between Congenital Lung Malformations and Lung Tumors in Children and Adults: A Systematic Review

“…All cases of BAC but one occurred in association with CPAM1. 34,[50][51][52][53][54][55][56][57][58][59][60] One case of BAC was associated with CPAM1 and CPAM2. 61 An AC arose from a BC in one case, 62 and foci of BAC were found in CPAM1 in another case.…”

Prenatal and Postnatal Management of Congenital Pulmonary Airway Malformation

“…Mucinous cells within CPAM type I produce gastric mucins similar to those found in BAC and have an increased frequency of KRAS mutations as well as a loss of heterozygosity at the tumour suppressor genes FHIT , p16INK4 and Rb [127]. The concept of malignant progression from type I CPAM to atypical goblet cell hyperplasia, or atypical adenomatous hyperplasia to BAC, has been supported by reports in which all the stages are present [131]. …”