Mucinous Appendiceal Neoplasms: Incidence, Diagnosis and Surgical Treatment

Nutu, Oana Anisa; Quinto, Alberto Alejandro Marcacuzco; Municio, Alejandro Manrique; Alonso, Iago Justo; Pulido, Jorge Calvo; García-Conde, María; Molero, Félix Cambra; Romero, Luis Carlos Jiménez

doi:10.1016/j.cireng.2017.07.011

Cited by 19 publications

(20 citation statements)

References 26 publications

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“…6 Additionally, the mean age of the patients with appendiceal tumors in this study is consistent with the finding that the incidence of carcinoid tumors peaks in the 20-39 age demographic, 15 but is much younger than 57 years, the median reported age of appendiceal tumors in the literature. 11,[16][17][18] Our study found a higher prevalence of appendiceal endometriosis in confirmed endometriosis patients than other studies (18% vs. 12-13.2%), which may be due to the fact that out of 179 patients who possessed an appendix at the time of surgery, a high proportion, 135 (75.4%), underwent appendectomy. [5][6][7] Of note we found a 17% prevalence of fibrous obliteration in our cohort, which is not included in the total prevalence of appendiceal pathology due to its indeterminate clinical significance.…”

Section: Discussionmentioning

confidence: 45%

Appendectomy Should Be Performed During Minimally Invasive Surgery for Endometriosis

Nikou¹,

Tenzel²,

Hua³

et al. 2021

JSLS

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Objectives: To determine the prevalence of appendiceal histopathology in patients with confirmed endometriosis following minimally invasive surgery (MIS) for endometriosis. To determine whether pre-operative symptoms, age, intra-operative appendiceal appearance, or endometrioma laterality were associated with appendix histopathology in patients with suspected endometriosis.Methods: One hundred thirty-five patients ages 16-52 with suspected endometriosis undergoing MIS for endometriosis with concomitant appendectomy at two metropolitan academic hospitals from January 1, 2012 to June 30, 2017 were included in this retrospective chart-review study. Medical records were reviewed for pre-operative symptoms, age, intraoperative appendix appearance, appendix histopathology, histopathologically-confirmed endometriosis, and endometriomas.Results: In patients with confirmed endometriosis, the prevalence of all appendiceal histopathology was 25%, which included appendiceal endometriosis (18%), appendiceal tumors (2%), and inflammation (5%). Dyspareunia was the only pre-operative symptom significantly associated with appendiceal histopathology (p = 0.04). The presence of a right endometrioma was associated with appendiceal histopathology (p = 0.009). Additionally, appendiceal histopathology was not significantly associated with age nor intra-operative appendiceal characteristics. Conclusion:This manuscript adds to the limited pool of studies regarding appendiceal histopathology and appendiceal tumors in patients with suspected and confirmed endometriosis. On the basis of the high rate of histopathological appendices found in this population; the lack of association with possible diagnostic factors such as age, most pre-operative symptoms, and intra-operative appendiceal characteristics; and the relatively low risks of concomitant appendectomy, we suggest that surgeons consider concomitant appendectomies at the time of MIS for endometriosis.

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Section: Discussionmentioning

confidence: 45%

Appendectomy Should Be Performed During Minimally Invasive Surgery for Endometriosis

Nikou¹,

Tenzel²,

Hua³

et al. 2021

JSLS

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“…LGMNs are commonly incidental in the appendix. Additional interventions (e.g., cytoreductive surgery) may be required according to the histological grade and degree of dissemination in the case of perforation and peritoneal dissemination (pseudomyxoma peritonei) [15]. In addition, radical appendectomy instead of right hemicolectomy is recommended for all high-stage epithelial neoplasias of the appendix in the literature [16].…”

Section: Discussionmentioning

confidence: 99%

Incidental appendiceal neoplasias: ten years' experience with 1,642 patients

2020

Signa Vitae

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Background: Acute appendicitis is the most common surgical emergency. In this study, we investigated the rate of neoplasia among patients who underwent an appendectomy in our center, a large Tertiary Care Teaching Hospital. Methods: We retrospectively reviewed 1,642 cases of appendectomies performed between 2007 and 2017. In this study, the data included demographic data, operative and pathological findings, and additional procedures following the appendectomy. Results: Of the 1,642 appendectomies, 1,294 were laparoscopic, and 348 were open procedures. Appendiceal neoplasia was encountered in the examination of appendix specimens taken from 20 patients. Sessile serrated adenoma (SSRA) was found in seven patients, neuroendocrine tumor (NET) in six patients, low-grade mucinous neoplasia (LGMN) in four patients, mucinous cystadenoma (MCA) in two patients, and diffuse adenoma (DA) in one patient. Two patients underwent right hemicolectomy due to positive surgical margins from previous surgeries. Colonoscopy and computed tomography (CT) control were performed on all neoplasia patients during the postoperative period, and no additional pathology was seen. Conclusions: Although the probability of neoplasia after appendectomy is low, it should be considered. Adenomas and neuroendocrine tumors seem to be the most common neoplasias that are incidentally encountered in appendectomy specimens.

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“…Es una patología poco frecuente, se estima su prevalencia en menos del 0,5%; a pesar de dichos datos se han publicado estudios que indican que dicha patología se haya en aumento. Si bien se estima que la edad promedio de presentación ronda la sexta década de la vida, en nuestro caso se dio en la quinta (52 años), y coincidiendo en la prevalencia por sexo (estudios describen prevalencia del sexo femenino 62% sobre el masculino 38% (1,2) .…”

Section: Discussionunclassified

Cistoadenocarcinoma of Appendix: Diagnosis and Treatmentat Emergency Room

et al. 2018

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Tumor Cistoadenocarcinomamucinoso de apéndice es una patología poco frecuente, de baja prevalencia a la fecha con un estimado de menos de 0,5%. Usualmente el hallazgo se da alrededor de la sexta década de la vida, durante una intervención por sospecha de una Apendicitis aguda, puesto que clínicamente simula dicha patología. El objetivo de este estudio es reportar el caso clínico de un paciente de 55 años con hallazgo de Cistoadenocarcinomamucinoso de apéndice.

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Mucinous Appendiceal Neoplasms: Incidence, Diagnosis and Surgical Treatment

Cited by 19 publications

References 26 publications

Appendectomy Should Be Performed During Minimally Invasive Surgery for Endometriosis

Appendectomy Should Be Performed During Minimally Invasive Surgery for Endometriosis

Incidental appendiceal neoplasias: ten years' experience with 1,642 patients

Cistoadenocarcinoma of Appendix: Diagnosis and Treatmentat Emergency Room

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