Mucinous carcinoma of the gallbladder with signet ring cells

Fukuda, Takeshi; Sakimoto, Yoshihiro; Narita, Kenichi; Ariizumi, Masahiro; Aizawa, Yoshifusa; Fukuda, Kunihiko

doi:10.1016/j.radcr.2017.06.016

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Magnetic resonance imaging shows the lesions to be hypointense on T1WI and heterogeneously hyperintense on T2WI. Thus, the imaging features of MC, which shows an attenuation similar to bile and poor enhancement, may delay the diagnosis and lead to underestimation of tumour extent and stage . Hence, a pathological diagnosis is utmost important in guiding the patient management.…”

Section: Discussionmentioning

confidence: 99%

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Mucinous adenocarcinoma of gallbladder: Subcategorisation on fine‐needle aspiration cytology

Vallonthaiel

Yadav

Jain

et al. 2018

Diagnostic Cytopathology

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Background: Mucinous adenocarcinoma (MC) of gallbladder is a rare histological subtype of gallbladder carcinoma (CaGB) which presents at an advanced stage and is associated with a poor prognosis compared to the conventional CaGB. This variant has been described mostly as reports or series, except for a single detailed histological and immunohistochemical analysis. Till date, there are no studies describing the cytomorphology of MC in detail. Hence, we undertook this study to analyse the cytomorphological features of MC.Methods: A retrospective cytomorphological analysis was performed on MC identified out of all CaGB diagnosed on cytology over a period of last 4 years. The architectural and cellular features were recorded in a structured proforma.Results: Thirty-three cases (33/987, 3.3%) were identified as MC. Extracellular mucin >90% was seen only in 3 cases whereas the remaining 30 had 50%-90% mucin. The predominant architectural pattern was tight epithelial fragments (14/33). The tumour cells were mostly of intermediate size (31/33) and had moderate amount of cytoplasm (31/33). Majority of the cases showed moderate nuclear pleomorphism (28/33) and nuclear chromatin was fine granular (17/33) or vesicular (14/33). Most of the cases had single and small nucleoli (26/33). Presence of inflammation composed predominantly of polymorphs was noted in 25 cases. Majority of the cases showed no (15/33) or scant necrosis (13/33). Conclusion:The morphological features of MC can very well be demonstrated on cytology. As they are associated with poor prognosis compared to conventional CaGB, cytopathologists should try to document the subtype.

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Section: Discussionmentioning

confidence: 99%

“…1 Literature on MCGB is rare. Other than the comprehensive study by Dursun et al, most are case reports, 7 mainly describing the radiological features [8][9][10] or association with other histological variants or diseases. [11][12][13] There are no studies available in the literature describing the cytology of MCGB in detail.…”

Section: Discussionmentioning

confidence: 99%

Mucinous adenocarcinoma of gallbladder: Subcategorisation on fine‐needle aspiration cytology

Vallonthaiel

Yadav

Jain

et al. 2018

Diagnostic Cytopathology

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“…Gallbladder cancer is the most frequent cancer of the biliary system. The risk factors for the development of gallbladder cancer include long-standing gallstone disease, porcelain gallbladder, choledochal cyst, and ethnicity [ 1 - 3 ]. It is often detected in the advanced stages and is associated with poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Mucinous Adenocarcinoma of Gallbladder Presenting As Acute Calculous Cholecystitis

Gupta¹,

Indulkar²,

Varshney³

et al. 2021

Cureus

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Mucinous adenocarcinoma (MAC) is a rare type of gallbladder cancer accounting for less than 5% of the reported cases. It is characterized by mucin deposition involving more than 50% of the tumor volume. It is a distinct subtype of gallbladder cancer and associated with poor prognosis. Accurate preoperative diagnosis is difficult. Most of the cases are diagnosed incidentally during the histopathological examination of the resected gallbladder. We report the case of a 75-year-old man who presented with right upper abdominal pain, fever, and vomiting for 15 days. Abdominal ultrasound revealed acute calculous cholecystitis for which he underwent laparoscopic cholecystectomy. Histological examination of the gallbladder found ulcerated gallbladder mucosa lined with dysplastic epithelium. The tumor was mainly composed of dysplastic glands floating in the pools of mucin with invasion of the perivascular connective tissue suggestive of MAC. This case highlights the importance of histological examination of gallbladder after routine cholecystectomy.

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“…Gall bladder carcinoma is the most common type of tumor of the biliary tract and adenocarcinoma is the major histopathological subtype. Mucinous variant is a rare subtype and mucinous carcinoma (MC) accompanied with signet ring is extremely rare (2). When mucinous component exceeds 90% of the tumor, it is labeled as pure mucinous carcinoma (3).…”

Section: Introductionmentioning

confidence: 99%

Mucinous Adenocarcinoma of Gall Bladder: A Rare Entity in Gall Baldder Adenocarcinoma

Shukla

Garg

Gaur

et al. 2020

IJMBS

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Gall bladder carcinoma is the most common type of tumor of the biliary tract and adenocarcinoma is the major histopathological subtype. Mucinous variant is a rare subtype and mucinous carcinoma accompanied with signet ring is extremely rare. When mucinous component exceeds 90% of the tumor, it is labeled as pure mucinous carcinoma. Immunohistochemistry helps to distinguish primary mucinous adenocarcinoma of gall bladder from pseudo myxoma peritonei from appendiceal neoplasm. Mucinous carcinoma is CK 7 positive and CK20 negative. We report a case of mucinous adenocarcinoma arising from the fundus of the gall bladder. Keywords: Mucinous carcinoma, Gall bladder, Adenocarcinoma, Metastatic deposits

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Mucinous carcinoma of the gallbladder with signet ring cells

Cited by 6 publications

References 12 publications

Mucinous adenocarcinoma of gallbladder: Subcategorisation on fine‐needle aspiration cytology

Mucinous adenocarcinoma of gallbladder: Subcategorisation on fine‐needle aspiration cytology

Mucinous Adenocarcinoma of Gallbladder Presenting As Acute Calculous Cholecystitis

Mucinous Adenocarcinoma of Gall Bladder: A Rare Entity in Gall Baldder Adenocarcinoma

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