Mucinous carcinoma of the male breast with axillary lymph node metastasis: Report of a case based on fine needle aspiration cytology

Ingle, Anjali; Kulkarni, Anjali; Patil, Sunita P.; Kumbhakarna, N R; Bindu, Rajan S

doi:10.4103/0970-9371.93228

Cited by 7 publications

(8 citation statements)

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“…The cytological features of mucinous carcinoma include the presence of relatively uniform neoplastic cells with slightly enlarged round to oval nuclei containing small nucleoli arranged in cords or small nests, within a rich mucinous material ( 11 ). A few cases of mucinous carcinoma of the male breast successfully diagnosed by FNA have been reported ( 8 , 12 – 14 ), although FNA was not performed in the present case. Recently, Ingle et al documented a case of pure mucinous carcinoma with axillary lymph node metastasis in a 75-year-old male ( 8 ).…”

Section: Discussionmentioning

confidence: 74%

“…Therefore, certain researchers have suggested that axillary lymph node dissection may be unnecessary for pure mucinous carcinoma, and they recommend sentinel lymph node dissection instead for patients with this form of tumor ( 6 ). However, certain cases of pure mucinous carcinoma with axillary lymph node metastasis in the male breast have been reported ( 5 , 8 , 9 ), and a case of pure mucinous carcinoma with lung metastasis in the male breast has also been documented ( 10 ). Thus, sentinel lymph node technique and clinical follow-up are considered necessary for patients with mucinous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Mucinous carcinoma occurring in the male breast

et al. 2013

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Male breast carcinoma is an uncommon neoplasm, accounting for 0.6% of all breast carcinomas. Invasive ductal carcinoma of no special type is the most common type of male breast carcinoma, and mucinous carcinoma occurring in the male breast is extremely rare. In the present study, we report a case of mucinous carcinoma of the male breast and discuss the clinicopathological features of this type of tumor. A 63-year-old Japanese male presented with a gradually enlarged nodule in the right breast. The resected breast specimen revealed pure mucinous carcinoma and immunohistochemical analyses demonstrated that tumor cells were positive for estrogen receptor (ER), but negative for progesterone receptor (PgR). In addition, HER2 expression was not amplified. Pure mucinous carcinoma is generally associated with a low incidence of lymph node or distant metastases, and excellent disease-free survival in females. However, certain cases of this type of tumor with axillary lymph node metastasis in the male breast have been reported. In addition, the immunoprofiles of mucinous carcinoma in males are fundamentally the same as those in females. More than 90% of cases show positive immunoreactivity for ER and/or PgR, and HER2 expression is not amplified. However, it has been reported that breast cancer in males is more frequently positive for ER than in females, and has less HER2 overexpression. The high rate of hormone receptor-positive breast cancer in males is considered to be due to similar conditions as those in breast cancer in postmenopausal women. The pathogenesis of male breast carcinoma, including mucinous carcinoma, remains unclear; therefore, additional clinicopathological studies are required.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Mucinous carcinoma occurring in the male breast

et al. 2013

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“…[5][6][7] Review of the literature revealed majority of the published literature pertaining to the cytological diagnosis MC are single case reports with only few series available. [6][7][8][9][10] Adhikari et al 7 studied eight cases of MC (5 PMC + 3 MMC) and observed presence of ECM along with single and cluster of tumor cells floating in them and thin walled capillaries as prominent features in five cases of PMC. Three cases of MMC showed in addition to mucin, pleomorphic clusters of tumor cells (as observed in our study).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India

Chikkannaiah¹,

Thangngeo²,

Guruprasad³

et al. 2020

J Lab Physicians

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Introduction Mucinous carcinoma (MC) is a rare form of breast cancer. It accounts for 1 to 7% of the cases and characterized by the presence of extracellular mucin (ECM). Depending on the amount of mucin, it is classified into pure mucinous carcinoma (> 90%, PMC) and mixed mucinous carcinoma (MMC; < 90%). In comparison to most common subtypes, MC is having better prognosis. There exist clinicopathological differences among PMC and MMC and also MC and IDC-NOS. Materials and Methods MCs diagnosed between January 2012 and December 2017 were included. Fine needle aspiration cytology smears were screened for cellularity, ECM, nuclear pleomorphism, signet ring cells (SRC), mucinophages, and myxovascular fragments (MVF). Histopathology slides were screened to confirm the diagnosis. Immunohistochemistry slides were graded as per the standard protocol. Statistical analyses were performed by SPSS software. Results In the present study, MC constituted 3.3%. The mean age of the patients was 50.9 years. ECM, mucinophages, and SRC were the key diagnostic cytological features. The PMC and MMC were clinicopathologically distinct with respect to gross findings and lymph node status. MMCs were highly proliferative. The mean duration of follow-up was 24.5 months. Complications were more common in MMC than PMC. Lymph node involvement is the key prognostic factor and it is independent of other prognostic factors like age, size, and hormonal receptor status. Conclusion PMC are rare subtype of breast cancer. The diagnostic cytological features are ECM, MVF, and SRC. MMC and PMC are clinicopathologically and genetically distinct.

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“…It constitutes approximately 5% of all breast cancers in men, compared with 1%-2% in women with breast carcinomas (24). Non-Hodgkin lymphoma, malignant melanoma, oncocytic carcinoma, secretory carcinoma, mucinous carcinoma, and metaplastic carcinoma have been rarely reported (1,18,20,(24)(25)(26)(27)(28). Metastatic involvement of male breasts with SCC and melanoma are also identified sporadically (26).…”

Section: Discussionmentioning

confidence: 99%