Mucinous cystadenocarcinoma of the appendix in which contrast-enhanced ultrasonography was useful for assessing blood flow in a focal nodular lesion in the tumor cavity: A case report

Wakui, Noritaka; Fujita, Mitsuru; Yamauchi, Yasuyuki; Takeda, Yoshihiko; Ueki, Nobuo; Otsuka, Takafumi; Oba, Nobuyuki; Nishinakagawa, Shuta; Takezoe, Toshiko; Hiroyoshi, Junko; Kono, Yoshiharu; Katahira, Seiichiro; Minagawa, Masami; Takeda, Yasushi; Shiono, Saori; Kojima, Toshihisa

doi:10.3892/etm.2013.1094

Cited by 7 publications

(9 citation statements)

References 37 publications

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“…In two mucinous cystadenocarcinomas, cystic dilatation of the appendix (mucocele) with irregular wall thickening was seen on sonography, which correlated with pathologic findings. These findings were consistent with those of a previous study,[ 12 14 15 ] which reported that when cystic dilatation of the appendix is present, wall irregularity and internal soft-tissue density with nodular thickening are associated with malignancy on CT. On the other hand, five nonmucinous carcinomas (four adenocarcinomas and one signet-ring cell carcinoma) had relatively small inner luminal diameters and thickened appendiceal walls ( n = 4) or mass ( n = 1) combined with submucosal hypoechogenicity. According to a previous report,[ 16 17 18 19 20 ] malignant tumors of the colon demonstrated the following wall characteristics on a high-resolution sonographic examination: heterogeneous hypoechoic mass, irregular wall thickening, and absence of a layered appearance of the wall.…”

Section: Discussionsupporting

confidence: 93%

Sonographic findings of malignant appendix tumors in seven cases

et al. 2018

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We report the sonographic features of confirmed malignant appendiceal tumors in seven cases. The histologic diagnoses of these tumors were mucinous cystadenocarcinoma (n = 2), colonic type adenocarcinoma (n = 4), and signet-ring cell carcinoma (n = 1). The 2 mucinous cystadenocarcinomas showed mucocele type, which had markedly enlarged inner luminal diameters (mean, 23 mm; range, 15–31 mm) and thick, irregular walls (mean wall thickness, 5.5 mm; range, 5–6 mm). In contrast, the 5 nonmucinous carcinomas (4 adenocarcinomas and 1 signet-ring cell carcinoma) showed nonmucocele type, which had relatively small inner luminal diameters (mean ± standard deviation [SD], 6.6 ± 4.5 mm; range, 2–15 mm) and prominent wall thickening (mean wall thickness ± SD, 6.2 ± 2.3 mm; range, 3–10 mm). Of the 5 nonmucinous tumors, only one had a discernible mass, three had thick irregular walls, two had loss of the wall layer pattern, and four had submucosal hypoechogenicity. Regardless of the histologic type, five of the seven malignant appendiceal tumors showed a severe periappendiceal fat infiltration or periappendiceal abscess, suggestive of perforation. Although the sonographic findings of the malignant appendiceal tumors were nonspecific, some of the sonographic features seen in these seven cases may help radiologists consider the possibility of underlying malignant appendiceal tumors.

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Section: Discussionsupporting

confidence: 93%

Sonographic findings of malignant appendix tumors in seven cases

et al. 2018

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“…Because dystrophic calcification co-exists either with non-neoplastic diverticula or neoplasms, psammomatous calcification is observed only in neoplastic group. Soft tissue mass with curvilinear calcifications in the right lower quadrant detected with abdominal radiographs is a significant finding with regard to LGMN diagnosis [1,23,24]. In LGMNs, calcifications in the wall may be confirmed histopathologically.…”

Section: Discussionmentioning

confidence: 80%

The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?

Paşaoğlu¹,

Leblebıcı²,

Okçu³

et al. 2016

pjp

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Prevalences of diverticulum and low-grade mucinous neoplasm (LGMN) were reported as 0.04-2% and less than 1% in the appendix. In this study, the frequency of diverticulum in LGMN cases, the relationship between diverticula and periappendicular mucin, and the possible role of diverticula in pseudomyxoma peritonei pathogenesis were researched. Through systematic review and targeted search, 38 LGMN and 96 diverticula were identified, frequencies and relationship between diverticulum and LGMN were analysed. Diverticulum and LGMN were determined in 4.8% and 1.04%, respectively, of 1922 appendectomy materials specifically grossed by the same pathologist. The prevalence of diverticulum was higher in our study than literature. The difference may be due to detailed macroscopic examination. Diverticulum was detected in 60% of LGMN cases. The rate of diverticulum was found to be significantly higher in LGMNs than non-neoplastic diverticulum (p < 0.001). Periappendicular mucin deposition was significantly more frequent in LGMN cases with diverticulum than in other groups (p < 0.05). Follow-ups were available in 18 patients; none of them had mucin deposition in the peritoneal cavity. We detected that periappendicular mucin was highly associated with diverticula in LGMN cases. Periappendicular acellular mucin deposition may not give rise to pseudomyxoma peritonei. We may think that mucin could move out of the appendix through the diverticulum rather than neoplastic spread in some of these cases.

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“…(E) The increase in the echogenicity in the Tx group was more prominent at POD 56 than at POD 14. was used to detect liver tumors in animal models (24,25) and in the clinic (26). Currently, the second-generation contrast agent, Sonazoid 1 (NC100100), is widely used to detect many types of gastroenterological tumor (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%