Mucinous Cystadenocarcinoma of the Breast: Report of 2 Cases Including One With Long-Term Local Recurrence

Nayak, Anupma; Bleiweiss, Ira J.; Dumoff, Kimberly L.; Bhuiya, Tawfiqul

doi:10.1177/1066896918775810

Cited by 18 publications

(46 citation statements)

References 19 publications

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“…Only 1 patient reported so far developed local recurrence. 21 None of the previous cases revealed evidence of distant metastasis. Our patient is receiving adjuvant therapy and has successfully completed 5 cycles of chemotherapy so far.…”

Section: Discussionmentioning

confidence: 90%

Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature

Jain¹,

Kumar²,

Jain

et al. 2021

Int J Surg Pathol

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Primary mucinous cystadenocarcinoma (MCA) of the breast is a rare variant of breast carcinoma known to have a favorable prognosis despite showing a basal-like phenotype. We describe a case of MCA breast in a 45-year-old female with a palpable mass in the breast. On the basis of the histopathological and immunohistochemical evaluation of a lumpectomy specimen with the absence of mass anywhere else on whole-body imaging, a diagnosis of primary MCA was rendered. Mismatch repair protein evaluation showed this tumor to be microsatellite stable. Molecular testing revealed the absence of Kirsten rat sarcoma viral oncogene homolog (KRAS), neuroblastoma RAS viral oncogene homolog (NRAS), and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations. To date only 27 cases of MCA breast have been reported. To the best of our knowledge, ours is the first case documenting diffuse Cytokeratin 20 (CK20) positivity, microsatellite stability, and the absence of KRAS, NRAS, and BRAF mutations in these tumors. The rarity of this tumor further evokes an interest in this case. A better understanding of the disease warrants a review of more cases with longer follow-ups.

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Section: Discussionmentioning

confidence: 90%

Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature

Jain¹,

Kumar²,

Jain

et al. 2021

Int J Surg Pathol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of primary mucinous cystadenocarcinoma of the breast is poorly understood due to its rarity and lack of molecular studies 2,3 . Even though the majority of these tumors are triple negative, the limited reports in the literature suggest that mucinous cystadenocarcinomas have a good prognosis as no deaths related to the disease have been reported 2,3 . Herein, we present the genetic profile of a case of mucinous cystadenocarcinoma of the breast characterized by mutations in TP53 , RB1 , and BAP1 genes, a molecular pattern driven by alterations in tumor suppressor genes.…”

Section: Discussionmentioning

confidence: 99%

“…There is no myoepithelial cell layer. These tumors have been described to be typically triple negative 2,3 . Most studies in the literature report good prognosis with low rates of axillary involvement and recurrences.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies in the literature report good prognosis with low rates of axillary involvement and recurrences. Differential diagnosis includes invasive mucinous carcinoma of the breast and metastatic mucinous cystadenocarcinoma, in particular, from ovarian and pancreatic origin 1–3 …”

Section: Introductionmentioning

confidence: 99%

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Genetic profile of primary mucinous cystadenocarcinoma of the breast—A case report

et al. 2021

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Primary mucinous cystadenocarcinoma of the breast is a rare neoplasm with few reports in the literature. Here, we report for the first time a comprehensive genetic profile of a primary mucinous cystadenocarcinoma of the breast, using next-generation sequencing 580 cancer-associated gene panel. Mutations in TP53, RB1, and BAP1 were identified. The findings suggest that this tumor is driven mostly by abnormalities in tumor suppressor genes, primarily involved in cell cycle control and chromatin remodeling. Molecular characterization of additional primary mucinous cystadenocarcinomas of the breast is warranted and might provide information related to its biology and behavior.

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Pure mucinous adenocarcinoma of the breast with the rare lymphoplasmacytic infiltration: A case report with review of literature

Prajapati,

Bhabhor,

Mehta

et al. 2024

Clinical Case Reports

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Key Clinical MessageA unique ER/PR‐positive mucinous adenocarcinoma of breast but CK7/CK20 negativity. A rare finding of Lymphoplasmacytic Infiltration is noted. Successful treatment included modified radical mastectomy and tamoxifen‐based therapy, leads to remission.AbstractMucinous carcinoma, which is characterized by the presence of abundant extracellular mucin, is a rare and distinctive subtype of invasive breast cancer. This subtype accounts for less than 5% of all invasive breast cancers, with pure mucinous carcinoma representing only around 2%. It is most commonly found in older patients, typically in the sixth to early eighth decade of life. We present the case of a 55‐year‐old female with a 15‐year history of a painless, gradually enlarging palpable lump on her left breast. Upon examination, a 5 × 5 cm lump with well‐defined margins and a hard consistency was found in the lower outer quadrant of the left breast. Histopathological examination confirmed a diagnosis of Mucinous Adenocarcinoma of the Left Breast. The patient underwent modified radical mastectomy and received adjuvant endocrine therapy with tamoxifen due to hormone receptor‐positive status. Mucinous carcinoma of the breast is a unique entity with specific histological features including the presence of extracellular mucin pools. Immunohistochemical staining is crucial for determining hormone receptor status, which can guide treatment decisions. Although surgical intervention is the primary approach, the extent of surgery may vary, ranging from lumpectomy to mastectomy. Adjuvant therapies such as chemotherapy and radiotherapy may also be considered based on individual cases. This case underscores the importance of a multidisciplinary approach in managing rare subtypes of breast cancer, such as mucinous carcinoma. Accurate diagnosis, appropriate surgical intervention, adjuvant therapy, and long‐term follow‐up are critical components of treatment.

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Mucinous Cystadenocarcinoma of the Breast: Report of 2 Cases Including One With Long-Term Local Recurrence

Cited by 18 publications

References 19 publications

Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature

Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature

Genetic profile of primary mucinous cystadenocarcinoma of the breast—A case report

Pure mucinous adenocarcinoma of the breast with the rare lymphoplasmacytic infiltration: A case report with review of literature

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