Mucinous cystadenoma of the appendix presenting with an elevated carcinoembryonic antigen (CEA): Report of two cases and review of the literature

McFarlane, Michael; Plummer, JM; Bonadie, Kimon O

doi:10.1016/j.ijscr.2013.07.007

Cited by 31 publications

(36 citation statements)

References 13 publications

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“…The benign tumor is commonly found in pancreas and ovaries, as well as in the appendix (2)(3)(4). In the lung, however, only a few cases have been reported world-wide (5-7).…”

Section: Introductionmentioning

confidence: 99%

Mucinous cystadenocarcinoma arising from mucinous cystadenoma of the lung: case report and review of the literature

et al. 2018

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Mucinous cystadenoma is a benign tumor commonly found in the pancreas, the ovaries or the appendix. Only very few cases of these tumors originating from the lungs have been reported worldwide, with even less cases describing malignant transformation. We present the case of a 58-year-old woman with a history of recurrent pulmonary infections who underwent left upper lobectomy for lung abscess and was initially diagnosed with pulmonary mucinous cystadenoma (PMCA). Upon thorough immunohistochemical workup, especially due to carcinoembryonic antigen (CEA) positivity, intramucinous singlet cells were eventually diagnostic for invasive carcinoma, in this case a mucinous cystadenocarcinoma arising from a PCMA. PMCA is a rare benign tumor whose potential for malignant transformation has not yet been fully understood. Due to the low number of cases further studies are needed to evaluate if there is a benefit of complete oncologic resection, provided the general condition of the patient allows it. A review of the currently available literature serves to better understand the clinical, radiological and histological features of this rare tumor.

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“…The benign tumor is commonly found in pancreas and ovaries, as well as in the appendix (2)(3)(4). In the lung, however, only a few cases have been reported world-wide (5-7).…”

Section: Introductionmentioning

confidence: 99%

Mucinous cystadenocarcinoma arising from mucinous cystadenoma of the lung: case report and review of the literature

et al. 2018

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“…Serum carcinoembryonic antigen (CEA), a common lung cancer tumor marker (TM), is a cell adhesion molecule in the immunoglobulin super family with the roles in homophilic and heterophilic adhesions (McFarlane et al, 2013). Excessive CEA expression leads to aberrant cell adhesion and inhibits cell apoptosis in the cancer cell nest, consequently making the cell escape apoptosis and increasing the metastatic opportunity of tumor cells (Ordoñez et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Analysis of CEA Expression and EGFR Mutation Status in Non-small Cell Lung Cancers

Yang¹,

Ding²,

Pen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The serum carcinoembryonic antigen (CEA) level can reflect tumor growth, recurrence and metastasis. It has been reported that epidermal growth factor receptor (EGFR) mutations in exons 19 and 21may have an important relationship with tumor cell sensitivity to EGFR -TKI therapy. In this study, we investigated the clinical value of EGFR mutations and serum CEA in patients with non-small cell lung cancer (NSCLC). Materials and Methods:The presence of mutations in EGFR exons 19 and 21 in the tissue samples of 315 patients with NSCLC was detected with real-time fluorescent PCR technology, while the serum CEA level in cases who had not yet undergone surgery, radiotherapy, chemotherapy and targeted therapy were assessed by electrochemical luminescence. Results: The mutation rates in EGFR exons 19 and 21 were 23.2% and 14.9%, respectively, with the two combined in 3.81%. Measured prior to the start of surgery, radiotherapy, chemotherapy and targeted treatment, serum CEA levels were abnormally high in 54.3% of the patients. In those with a serum CEA level <5 ng/mL, the EGFR mutation rate was 18.8%, while with 5~19 ng/mL and ≥20 ng/mL, the rates were 36.4% and 62.5%. In addition, in the cohort of patients with the CEA level being 20~49 ng/mL, the EGFR mutation rate was 85.7%, while in those with the CEA level ≥50 ng/mL, the EGFR mutation rate was only 20.0%, approximately the same as in cases with the CEA level<5 ng/mL. Conclusions: There is a positive correlation between serum CEA expression level and EGFR mutation status in NSCLC patients, namely the EGFR mutation-positive rate increases as the serum CEA expression level rises within a certain range (≥20 ng/mL, especially 20~49 ng/mL). If patient samples are not suitable for EGFR mutation testing, or cannot be obtained at all, testing serum CEA levels might be a simple and easy screening method. Hence, for the NSCLC patients with high serum CEA level (≥20 ng/mL, especially 20~49 ng/mL), it is worthy of attempting EGFR-TKI treatment, which may achieve better clinical efficacy and quality of life.

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“…[7,14] Tumor markers, such as carcinoembryonic antigen and cancer antigen 19.9, are not very valuable in this instance. [15,16] Surgical strategies for these patients differ widely. As a standard approach, although an appendectomy is considered sufficient in cases of cystadenoma or hyperplasia, in patients with cystadenocarcinoma it should be combined with a right hemicolectomy.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Giant Mixed Adenoneuroendocrine Carcinoma: Case Report

Bildik¹,

Kaya²,

Kaptanoğlu³

et al. 2018

South Clin Ist Euras

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Mucinous cystadenoma of the appendix presenting with an elevated carcinoembryonic antigen (CEA): Report of two cases and review of the literature

Abstract: Because the diagnosis is rarely suspected prior to surgery patients with an enlarged appendix with associated elevated CEA levels should have careful investigations to exclude malignancy.

Cited by 31 publications

References 13 publications

Mucinous cystadenocarcinoma arising from mucinous cystadenoma of the lung: case report and review of the literature

Mucinous cystadenocarcinoma arising from mucinous cystadenoma of the lung: case report and review of the literature

Analysis of CEA Expression and EGFR Mutation Status in Non-small Cell Lung Cancers

Retroperitoneal Giant Mixed Adenoneuroendocrine Carcinoma: Case Report

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